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Novel BET protein proteolysis-targeting chimera exerts superior lethal activity than bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm secondary (s) AML cells

Leukemia, 2017-09, Vol.31 (9), p.1951-1961

2017

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Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer

Oncogene, 2008-12, Vol.27 (57), p.7201-7211

2008

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BET protein proteolysis targeting chimera (PROTAC) exerts potent lethal activity against mantle cell lymphoma cells

Leukemia, 2018-02, Vol.32 (2), p.343-352

2018

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Structure of Human Methionine Aminopeptidase-2 Complexed with Fumagillin

Science (American Association for the Advancement of Science), 1998-11, Vol.282 (5392), p.1324-1327

1998

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The ubiquitin-proteasome pathway and proteasome inhibitors

Medicinal research reviews, 2001-07, Vol.21 (4), p.245-273

2001

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The Primary Structure of MEK, a Protein Kinase That Phosphorylates the ERK Gene Product

Science (American Association for the Advancement of Science), 1992-10, Vol.258 (5081), p.478-480

1992

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Molecular and Cellular Basis of Regeneration and Tissue Repair: Wound epidermis formation and function in urodele amphibian limb regeneration

Cellular and molecular life sciences : CMLS, 2008, Vol.65 (1), p.73-79

2008

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Wound epidermis formation and function in urodele amphibian limb regeneration

Cellular and molecular life sciences : CMLS, 2008-01, Vol.65 (1), p.73-79

2008

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Total synthesis of the-potent proteasome inhibitor epoxomicin: a useful tool for understanding proteasome biology

Bioorganic & medicinal chemistry letters, 1999-08, Vol.9 (15), p.2283-2288

1999

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Protacs: Chimeric Molecules That Target Proteins to the Skp1-Cullin-F Box Complex for Ubiquitination and Degradation

Proceedings of the National Academy of Sciences - PNAS, 2001-07, Vol.98 (15), p.8554-8559

2001

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Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro

The Journal of clinical investigation, 2003-06, Vol.111 (11), p.1771-1782

2003

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Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro

Molecular and Cellular Biology, 1993-11, Vol.13 (11), p.6615-6620

1993

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Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD

Nephrology, dialysis, transplantation, 2010-07, Vol.25 (7), p.2187-2194

2010

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Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product

Proceedings of the National Academy of Sciences - PNAS, 1992-09, Vol.89 (17), p.8205-8209

1992

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Interleukin 2 Stimulation of p70 S6 Kinase Activity is Inhibited by the Immunosuppressant Rapamycin

Proceedings of the National Academy of Sciences - PNAS, 1992-08, Vol.89 (16), p.7571-7575

1992

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Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: Insights into specificity and potency

Bioorganic & medicinal chemistry letters, 1999-12, Vol.9 (23), p.3335-3340

1999

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Epoxomicin, a Potent and Selective Proteasome Inhibitor, Exhibits in vivo Antiinflammatory Activity

Proceedings of the National Academy of Sciences - PNAS, 1999-08, Vol.96 (18), p.10403-10408

1999

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Raf-1 Forms a Stable Complex with Mek1 and Activates Mek1 by Serine Phosphorylation

Proceedings of the National Academy of Sciences - PNAS, 1993-12, Vol.90 (23), p.10947-10951

1993

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Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro

The Journal of clinical investigation, 2003-06, Vol.111 (11), p.1771-1782

2003

Volltextzugriff (PDF)

Phorbol Ester Stimulates a Protein-Tyrosine/Threonine Kinase that Phosphorylates and Activates the Erk-1 Gene Product

Proceedings of the National Academy of Sciences - PNAS, 1992-09, Vol.89 (17), p.8200-8204

1992

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Eponemycin exerts its antitumor effect through the inhibition of proteasome function

Cancer research (Chicago, Ill.), 1999-06, Vol.59 (12), p.2798-2801

1999

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The Anti-Angiogenic Agent Fumagillin Covalently Binds and Inhibits the Methionine Aminopeptidase, MetAP-2

Proceedings of the National Academy of Sciences - PNAS, 1997-06, Vol.94 (12), p.6099-6103

1997

Volltextzugriff (PDF)

Targeted protein degradation: elements of PROTAC design

Current opinion in chemical biology, 2019-06, Vol.50, p.111-119

2019

Volltextzugriff (PDF)

Mouse Erk-1 Gene Product is a Serine/Threonine Protein Kinase That has the Potential to Phosphorylate Tyrosine

Proceedings of the National Academy of Sciences - PNAS, 1991-10, Vol.88 (19), p.8845-8849

1991

Volltextzugriff (PDF)

Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase

Molecular and Cellular Biology, 1989-09, Vol.9 (9), p.3850-3859

1989

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Novel BET protein proteolysis-targeting chimera exerts superior lethal activity than bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm secondary (s) AML cells

Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer

BET protein proteolysis targeting chimera (PROTAC) exerts potent lethal activity against mantle cell lymphoma cells

Structure of Human Methionine Aminopeptidase-2 Complexed with Fumagillin

The ubiquitin-proteasome pathway and proteasome inhibitors

The Primary Structure of MEK, a Protein Kinase That Phosphorylates the ERK Gene Product

Molecular and Cellular Basis of Regeneration and Tissue Repair: Wound epidermis formation and function in urodele amphibian limb regeneration

Wound epidermis formation and function in urodele amphibian limb regeneration

Total synthesis of the-potent proteasome inhibitor epoxomicin: a useful tool for understanding proteasome biology

Protacs: Chimeric Molecules That Target Proteins to the Skp1-Cullin-F Box Complex for Ubiquitination and Degradation

Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro

Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro

Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD

Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product

Interleukin 2 Stimulation of p70 S6 Kinase Activity is Inhibited by the Immunosuppressant Rapamycin

Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: Insights into specificity and potency

Epoxomicin, a Potent and Selective Proteasome Inhibitor, Exhibits in vivo Antiinflammatory Activity

Raf-1 Forms a Stable Complex with Mek1 and Activates Mek1 by Serine Phosphorylation

Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro

Phorbol Ester Stimulates a Protein-Tyrosine/Threonine Kinase that Phosphorylates and Activates the Erk-1 Gene Product

Eponemycin exerts its antitumor effect through the inhibition of proteasome function

The Anti-Angiogenic Agent Fumagillin Covalently Binds and Inhibits the Methionine Aminopeptidase, MetAP-2

Targeted protein degradation: elements of PROTAC design

Mouse Erk-1 Gene Product is a Serine/Threonine Protein Kinase That has the Potential to Phosphorylate Tyrosine

Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase

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