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Two Approaches to Discovering and Developing New Drugs for Chagas Disease

Memórias do Instituto Oswaldo Cruz, 2009-07, Vol.104 (s1), p.263-269

2009

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Substrate Specificity Profiling and Identification of a New Class of Inhibitor for the Major Protease of the SARS Coronavirus

Biochemistry (Easton), 2007-07, Vol.46 (30), p.8744-8752

2007

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Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin

Nature biotechnology, 2000-02, Vol.18 (2), p.187-193

2000

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Structural basis of substrate specificity in the serine proteases

Protein science, 1995-03, Vol.4 (3), p.337-360

1995

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Lytic Replication of Kaposi's Sarcoma-Associated Herpesvirus Results in the Formation of Multiple Capsid Species: Isolation and Molecular Characterization of A, B, and C Capsids from a Gammaherpesvirus

Journal of Virology, 2001-03, Vol.75 (6), p.2866-2878

2001

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Structure of an affinity-matured inhibitory recombinant fab against urokinase plasminogen activator reveals basis of potency and specificity

Biochimica et biophysica acta. Proteins and proteomics, 2021-02, Vol.1869 (2), p.140562-140562, Article 140562

2021

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Engineering of a macromolecular scaffold to develop specific protease inhibitors

Nature biotechnology, 2003-09, Vol.21 (9), p.1063-1068

2003

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Structural determinants of specificity in the cysteine protease cruzain

Protein science, 1997-08, Vol.6 (8), p.1603-1611

1997

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Structure-Based Design of Nonpeptide Inhibitors Specific for the Human Immunodeficiency Virus 1 Protease

Proceedings of the National Academy of Sciences - PNAS, 1990-09, Vol.87 (17), p.6644-6648

1990

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Regulation of autoproteolysis of the HIV-1 and HIV-2 proteases with engineered amino acid substitutions

The Journal of biological chemistry, 1993-06, Vol.268 (16), p.11939-11945

1993

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The sequence, organization, and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi

The Journal of biological chemistry, 1992-04, Vol.267 (11), p.7411-7420

1992

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Cellular Localization of Membrane-type Serine Protease 1 and Identification of Protease-activated Receptor-2 and Single-chain Urokinase-type Plasminogen Activator as Substrates

The Journal of biological chemistry, 2000-08, Vol.275 (34), p.26333-26342

2000

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Rapid and General Profiling of Protease Specificity by Using Combinatorial Fluorogenic Substrate Libraries

Proceedings of the National Academy of Sciences - PNAS, 2000-07, Vol.97 (14), p.7754-7759

2000

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Human Mast Cell Tryptase: Multiple cDNAs and Genes Reveal a Multigene Serine Protease Family

Proceedings of the National Academy of Sciences - PNAS, 1990-05, Vol.87 (10), p.3811-3815

1990

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Defining the level of human immunodeficiency virus type 1 (HIV-1) protease activity required for HIV-1 particle maturation and infectivity

Journal of Virology, 1995-05, Vol.69 (5), p.2751-2758

1995

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A primary determinant for lipoxygenase positional specificity

Nature (London), 1991-11, Vol.354 (6349), p.149-152

1991

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Functional Consequences of the Kaposi's Sarcoma-Associated Herpesvirus Protease Structure: Regulation of Activity and Dimerization by Conserved Structural Elements

Biochemistry (Easton), 2000-10, Vol.39 (42), p.12796-12803

2000

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Evolutionary Divergence of Substrate Specificity within the Chymotrypsin-like Serine Protease Fold

The Journal of biological chemistry, 1997-11, Vol.272 (48), p.29987-29990

1997

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Replacement of Lysine Residue 1030 in the Putative ATP-Binding Region of the Insulin Receptor Abolishes Insulin- and Antibody-Stimulated Glucose Uptake and Receptor Kinase Activity

Proceedings of the National Academy of Sciences - PNAS, 1987-02, Vol.84 (3), p.704-708

1987

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Reverse Biochemistry: Use of Macromolecular Protease Inhibitors to Dissect Complex Biological Processes and Identify a Membrane-Type Serine Protease in Epithelial Cancer and Normal Tissue

Proceedings of the National Academy of Sciences - PNAS, 1999-09, Vol.96 (20), p.11054-11061

1999

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Production of crystallizable cruzain, the major cysteine protease from Trypanosoma cruzi

The Journal of biological chemistry, 1993-03, Vol.268 (9), p.6115-6118

1993

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Serine Proteases from Nematode and Protozoan Parasites: Isolation of Sequence Homologs Using Generic Molecular Probes

Proceedings of the National Academy of Sciences - PNAS, 1989-07, Vol.86 (13), p.4863-4867

1989

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The Catalytic Role of the Active Site Aspartic Acid in Serine Proteases

Science (American Association for the Advancement of Science), 1987-08, Vol.237 (4817), p.909-913

1987

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The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase

Biochemical journal, 2004-04, Vol.379 (Pt 1), p.107-118

2004

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Substrate Specificity of Trypsin Investigated by Using a Genetic Selection

Proceedings of the National Academy of Sciences - PNAS, 1990-09, Vol.87 (17), p.6659-6663

1990

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Two Approaches to Discovering and Developing New Drugs for Chagas Disease

Substrate Specificity Profiling and Identification of a New Class of Inhibitor for the Major Protease of the SARS Coronavirus

Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin

Structural basis of substrate specificity in the serine proteases

Lytic Replication of Kaposi's Sarcoma-Associated Herpesvirus Results in the Formation of Multiple Capsid Species: Isolation and Molecular Characterization of A, B, and C Capsids from a Gammaherpesvirus

Structure of an affinity-matured inhibitory recombinant fab against urokinase plasminogen activator reveals basis of potency and specificity

Engineering of a macromolecular scaffold to develop specific protease inhibitors

Structural determinants of specificity in the cysteine protease cruzain

Structure-Based Design of Nonpeptide Inhibitors Specific for the Human Immunodeficiency Virus 1 Protease

Regulation of autoproteolysis of the HIV-1 and HIV-2 proteases with engineered amino acid substitutions

The sequence, organization, and expression of the major cysteine protease (cruzain) from Trypanosoma cruzi

Cellular Localization of Membrane-type Serine Protease 1 and Identification of Protease-activated Receptor-2 and Single-chain Urokinase-type Plasminogen Activator as Substrates

Rapid and General Profiling of Protease Specificity by Using Combinatorial Fluorogenic Substrate Libraries

Human Mast Cell Tryptase: Multiple cDNAs and Genes Reveal a Multigene Serine Protease Family

Defining the level of human immunodeficiency virus type 1 (HIV-1) protease activity required for HIV-1 particle maturation and infectivity

A primary determinant for lipoxygenase positional specificity

Functional Consequences of the Kaposi's Sarcoma-Associated Herpesvirus Protease Structure: Regulation of Activity and Dimerization by Conserved Structural Elements

Evolutionary Divergence of Substrate Specificity within the Chymotrypsin-like Serine Protease Fold

Replacement of Lysine Residue 1030 in the Putative ATP-Binding Region of the Insulin Receptor Abolishes Insulin- and Antibody-Stimulated Glucose Uptake and Receptor Kinase Activity

Reverse Biochemistry: Use of Macromolecular Protease Inhibitors to Dissect Complex Biological Processes and Identify a Membrane-Type Serine Protease in Epithelial Cancer and Normal Tissue

Production of crystallizable cruzain, the major cysteine protease from Trypanosoma cruzi

Serine Proteases from Nematode and Protozoan Parasites: Isolation of Sequence Homologs Using Generic Molecular Probes

The Catalytic Role of the Active Site Aspartic Acid in Serine Proteases

The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase

Substrate Specificity of Trypsin Investigated by Using a Genetic Selection

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