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HPLC-API/MS/MS: a powerful tool for integrating drug metabolism into the drug discovery process

Drug discovery today, 1997-12, Vol.2 (12), p.532-537

1997

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Demonstration of the capabilities of a parallel high performance liquid chromatography tandem mass spectrometry system for use in the analysis of drug discovery plasma samples

Rapid communications in mass spectrometry, 1999-10, Vol.13 (20), p.1991-1998

1999

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Rapid determination of pharmacokinetic properties of new chemical entities: in vivo approaches

Combinatorial chemistry & high throughput screening, 2002-02, Vol.5 (1), p.29

2002

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Improving the Oral Efficacy of CNS Drug Candidates: Discovery of Highly Orally Efficacious Piperidinyl Piperidine M2 Muscarinic Receptor Antagonists

Journal of medicinal chemistry, 2002-12, Vol.45 (25), p.5415-5418

2002

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Resonance Ejection Ion Trap Mass Spectrometry and Nonlinear Field Contributions: The Effect of Scan Direction on Mass Resolution

Analytical chemistry (Washington), 1994-03, Vol.66 (5), p.725-729

1994

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Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M2 muscarinic receptor antagonists via benzamide modification

Bioorganic & medicinal chemistry letters, 2002-12, Vol.12 (23), p.3479-3482

2002

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Systematic LC/MS metabolite identification in drug discovery

Analytical chemistry (Washington), 2001-08, Vol.73 (15), p.430A-439A

2001

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Metabolic stabilization of benzylidene ketal M2 muscarinic receptor antagonists via halonaphthoic acid substitution

Bioorganic & medicinal chemistry letters, 2001-09, Vol.11 (17), p.2311-2314

2001

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Chemiluminescence Detection of Amino Acids, Peptides, and Proteins Using Tris-2,2′-Bipyridine Ruthenium (III)

Analytical letters, 1990-02, Vol.23 (2), p.195-210

1990

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Isolation of circulating metabolites in drug discovery using high-performance liquid chromatography, and their identification by liquid chromatography coupled with tandem mass spectrometry and nuclear magnetic resonance spectroscopy

Journal of separation science, 2002-10, Vol.25 (14), p.877-882

2002

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Cassette-accelerated rapid rat screen: a systematic procedure for the dosing and liquid chromatography/atmospheric pressure ionization tandem mass spectrometric analysis of new chemical entities as part of new drug discovery

Rapid communications in mass spectrometry, 2001-01, Vol.15 (5), p.335-340

2001

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Role of the site of protonation in the low-energy decompositions of gas-phase peptide ions

Journal of the American Society for Mass Spectrometry, 1996-06, Vol.7 (6), p.522-531

1996

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Novel in vivo procedure for rapid pharmacokinetic screening of discovery compounds in rats

Drug Discovery Today, 1999-05, Vol.4 (5), p.232-237

1999

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Molecular heterogeneity in the Major Urinary Proteins of the house mouse Mus musculus

Biochemical journal, 1996-05, Vol.316 ( Pt 1) (1), p.265-272

1996

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Peer Reviewed: Systematic LC/MS Metabolite Identification in Drug Discovery

Analytical chemistry (Washington), 2001-08, Vol.73 (15), p.430 A-439 A

2001

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Systematic LC/MS metabolite identification in drigs discovery

Analytical chemistry (Washington), 2001, Vol.73 (15), p.A430-A439

2001

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Improving the Oral Efficacy of CNS Drug Candidates: Discovery of Highly Orally Efficacious Piperidinyl Piperidine M 2 Muscarinic Receptor Antagonists

Journal of medicinal chemistry, 2002-12, Vol.45 (25), p.5415-5418

2002

Volltextzugriff (PDF)

Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M 2 muscarinic receptor antagonists via benzamide modification

Bioorganic & medicinal chemistry letters, 2002-12, Vol.12 (23), p.3479-3482

2002

Volltextzugriff (PDF)

Metabolic stabilization of benzylidene ketal M 2 muscarinic receptor antagonists via halonaphthoic acid substitution

Bioorganic & medicinal chemistry letters, 2001-09, Vol.11 (17), p.2311-2314

2001

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Mass shifts due to ion/ion interactions in a quadrupole ion-trap mass spectrometer

Rapid communications in mass spectrometry, 1994-06, Vol.8 (6), p.451-454

1994

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Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M(2) muscarinic receptor antagonists via benzamide modification

Bioorganic & medicinal chemistry letters, 2002-12, Vol.12 (23), p.3479-3482

2002

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High mass-resolution using a quadrupole ion-trap mass spectrometer

Rapid communications in mass spectrometry, 1991-07, Vol.5 (7), p.327-329

1991

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Efficient trapping and collision-induced dissociation of high-mass cluster ions using mixed target gases in the quadrupole ion trap

Rapid communications in mass spectrometry, 1992-08, Vol.6 (8), p.520-523

1992

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Peer Reviewed: Systematic LC/MS Metabolite Identification in Drug Discovery: A four-step strategy to characterize metabolites by LC/MS techniques early in the pharmaceutical discovery process

Analytical chemistry (Washington), 2001-08, Vol.73 (15), p.430 A-439 A

2001

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Chapter 7 The utility of in vitro screening for the assessment of electrophilic metabolite formation early in drug discovery using hplc-ms/ms

Progress in Pharmaceutical and Biomedical Analysis, 2005, Vol.6, p.159-182

2005

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HPLC-API/MS/MS: a powerful tool for integrating drug metabolism into the drug discovery process

Demonstration of the capabilities of a parallel high performance liquid chromatography tandem mass spectrometry system for use in the analysis of drug discovery plasma samples

Rapid determination of pharmacokinetic properties of new chemical entities: in vivo approaches

Improving the Oral Efficacy of CNS Drug Candidates: Discovery of Highly Orally Efficacious Piperidinyl Piperidine M2 Muscarinic Receptor Antagonists

Resonance Ejection Ion Trap Mass Spectrometry and Nonlinear Field Contributions: The Effect of Scan Direction on Mass Resolution

Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M2 muscarinic receptor antagonists via benzamide modification

Systematic LC/MS metabolite identification in drug discovery

Metabolic stabilization of benzylidene ketal M2 muscarinic receptor antagonists via halonaphthoic acid substitution

Chemiluminescence Detection of Amino Acids, Peptides, and Proteins Using Tris-2,2′-Bipyridine Ruthenium (III)

Isolation of circulating metabolites in drug discovery using high-performance liquid chromatography, and their identification by liquid chromatography coupled with tandem mass spectrometry and nuclear magnetic resonance spectroscopy

Cassette-accelerated rapid rat screen: a systematic procedure for the dosing and liquid chromatography/atmospheric pressure ionization tandem mass spectrometric analysis of new chemical entities as part of new drug discovery

Role of the site of protonation in the low-energy decompositions of gas-phase peptide ions

Novel in vivo procedure for rapid pharmacokinetic screening of discovery compounds in rats

Molecular heterogeneity in the Major Urinary Proteins of the house mouse Mus musculus

Peer Reviewed: Systematic LC/MS Metabolite Identification in Drug Discovery

Systematic LC/MS metabolite identification in drigs discovery

Improving the Oral Efficacy of CNS Drug Candidates: Discovery of Highly Orally Efficacious Piperidinyl Piperidine M 2 Muscarinic Receptor Antagonists

Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M 2 muscarinic receptor antagonists via benzamide modification

Metabolic stabilization of benzylidene ketal M 2 muscarinic receptor antagonists via halonaphthoic acid substitution

Mass shifts due to ion/ion interactions in a quadrupole ion-trap mass spectrometer

Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M(2) muscarinic receptor antagonists via benzamide modification

High mass-resolution using a quadrupole ion-trap mass spectrometer

Efficient trapping and collision-induced dissociation of high-mass cluster ions using mixed target gases in the quadrupole ion trap

Peer Reviewed: Systematic LC/MS Metabolite Identification in Drug Discovery: A four-step strategy to characterize metabolites by LC/MS techniques early in the pharmaceutical discovery process

Chapter 7 The utility of in vitro screening for the assessment of electrophilic metabolite formation early in drug discovery using hplc-ms/ms

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