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Identification and validation of the microRNA response elements in the 3′-untranslated region of the UDP glucuronosyltransferase (UGT) 2B7 and 2B15 genes by a functional genomics approach

Biochemical pharmacology, 2017-12, Vol.146, p.199-213

2017

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Identification and validation of microRNAs directly regulating the UDP-glucuronosyltransferase 1A subfamily enzymes by a functional genomics approach

Biochemical pharmacology, 2017-08, Vol.137, p.93-106

2017

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Transcriptome association analysis identifies miR-375 as a major determinant of variable acetaminophen glucuronidation by human liver

Biochemical pharmacology, 2016-10, Vol.117, p.78-87

2016

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Quantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues

Xenobiotica, 2012-03, Vol.42 (3), p.266-277

2012

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Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization

Scientific reports, 2020-01, Vol.10 (1), p.69-69, Article 69

2020

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Pharmacogenomics of poor drug metabolism in greyhounds: Canine P450 oxidoreductase genetic variation, breed heterogeneity, and functional characterization

PloS one, 2024-02, Vol.19 (2), p.e0297191-e0297191

2024

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Isoform‐Selective Probe Substrates for In Vitro Studies of Human UDP‐Glucuronosyltransferases

Methods in Enzymology, 2005, Vol.400, p.104-116

Court, Michael H.

2005

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Absolute Quantitation of Drug-Metabolizing Cytochrome P450 Enzymes and Accessory Proteins in Dog Liver Microsomes Using Label-Free Standard-Free Analysis Reveals Interbreed Variability

Drug metabolism and disposition, 2019-11, Vol.47 (11), p.1314-1324

2019

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Identification by whole genome sequencing of genes associated with delayed postoperative hemorrhage in Scottish deerhounds

Journal of veterinary internal medicine, 2023-03, Vol.37 (2), p.510-517

2023

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Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor

Drug metabolism and disposition, 2008-08, Vol.36 (8), p.1594-1605

2008

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Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers

British journal of clinical pharmacology, 2013-02, Vol.75 (2), p.450-462

2013

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CYP2B6, CYP2A6 and UGT2B7 genetic polymorphisms are predictors of efavirenz mid-dose concentration in HIV-infected patients

AIDS (London), 2009-10, Vol.23 (16), p.2101-2106

2009

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Evolution of a major drug metabolizing enzyme defect in the domestic cat and other felidae: phylogenetic timing and the role of hypercarnivory

PloS one, 2011-03, Vol.6 (3), p.e18046

2011

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CYP2B6 (c.516G→T) and CYP2A6 (9B and/or 17) polymorphisms are independent predictors of efavirenz plasma concentrations in HIV‐infected patients

British journal of clinical pharmacology, 2009-04, Vol.67 (4), p.427-436

2009

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Mechanism of cytochrome P450-3A inhibition by ketoconazole

Journal of pharmacy and pharmacology, 2011-02, Vol.63 (2), p.214-221

2011

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Evidence for regulation of UDP-glucuronosyltransferase (UGT) 1A1 protein expression and activity via DNA methylation in healthy human livers

Journal of pharmacy and pharmacology, 2013-06, Vol.65 (6), p.874-883

2013

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Favipiravir inhibits acetaminophen sulfate formation but minimally affects systemic pharmacokinetics of acetaminophen

British journal of clinical pharmacology, 2015-11, Vol.80 (5), p.1076-1085

2015

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Pharmacokinetics of acetaminophen after a single Oral administration of 20 or 40 mg/kg to 7-9 Day-old foals

Frontiers in veterinary science, 2023-07, Vol.10, p.1198940-1198940

2023

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Nicotine Glucuronidation and the Human UDP-Glucuronosyltransferase UGT2B10

Molecular pharmacology, 2007-09, Vol.72 (3), p.761-768

2007

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Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system

Drug metabolism reviews, 2010-02, Vol.42 (1), p.209-224

Court, Michael H.

2010

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Identification of canine cytochrome P‐450s (CYPs) metabolizing the tramadol (+)‐M1 and (+)‐M2 metabolites to the tramadol (+)‐M5 metabolite in dog liver microsomes

Journal of veterinary pharmacology and therapeutics, 2018-12, Vol.41 (6), p.815-824

2018

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Diabetes mellitus reduces activity of human UDP-glucuronosyltransferase 2B7 in liver and kidney leading to decreased formation of mycophenolic acid acyl-glucuronide metabolite

Drug metabolism and disposition, 2011-03, Vol.39 (3), p.448-455

2011

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Feline Drug Metabolism and Disposition: Pharmacokinetic Evidence for Species Differences and Molecular Mechanisms

The Veterinary clinics of North America. Small animal practice, 2013-09, Vol.43 (5), p.1039-1054

Court, Michael H

2013

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A Pharmacogenomics Primer

Journal of clinical pharmacology, 2007-09, Vol.47 (9), p.1087-1103

Court, Michael H.

2007

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Canine Cytochrome P-450 Pharmacogenetics

The Veterinary clinics of North America. Small animal practice, 2013-09, Vol.43 (5), p.1027-1038

Court, Michael H.

2013

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Identification and validation of the microRNA response elements in the 3′-untranslated region of the UDP glucuronosyltransferase (UGT) 2B7 and 2B15 genes by a functional genomics approach

Identification and validation of microRNAs directly regulating the UDP-glucuronosyltransferase 1A subfamily enzymes by a functional genomics approach

Transcriptome association analysis identifies miR-375 as a major determinant of variable acetaminophen glucuronidation by human liver

Quantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues

Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization

Pharmacogenomics of poor drug metabolism in greyhounds: Canine P450 oxidoreductase genetic variation, breed heterogeneity, and functional characterization

Isoform‐Selective Probe Substrates for In Vitro Studies of Human UDP‐Glucuronosyltransferases

Absolute Quantitation of Drug-Metabolizing Cytochrome P450 Enzymes and Accessory Proteins in Dog Liver Microsomes Using Label-Free Standard-Free Analysis Reveals Interbreed Variability

Identification by whole genome sequencing of genes associated with delayed postoperative hemorrhage in Scottish deerhounds

Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor

Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers

CYP2B6, CYP2A6 and UGT2B7 genetic polymorphisms are predictors of efavirenz mid-dose concentration in HIV-infected patients

Evolution of a major drug metabolizing enzyme defect in the domestic cat and other felidae: phylogenetic timing and the role of hypercarnivory

CYP2B6 (c.516G→T) and CYP2A6 (9B and/or 17) polymorphisms are independent predictors of efavirenz plasma concentrations in HIV‐infected patients

Mechanism of cytochrome P450-3A inhibition by ketoconazole

Evidence for regulation of UDP-glucuronosyltransferase (UGT) 1A1 protein expression and activity via DNA methylation in healthy human livers

Favipiravir inhibits acetaminophen sulfate formation but minimally affects systemic pharmacokinetics of acetaminophen

Pharmacokinetics of acetaminophen after a single Oral administration of 20 or 40 mg/kg to 7-9 Day-old foals

Nicotine Glucuronidation and the Human UDP-Glucuronosyltransferase UGT2B10

Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system

Identification of canine cytochrome P‐450s (CYPs) metabolizing the tramadol (+)‐M1 and (+)‐M2 metabolites to the tramadol (+)‐M5 metabolite in dog liver microsomes

Diabetes mellitus reduces activity of human UDP-glucuronosyltransferase 2B7 in liver and kidney leading to decreased formation of mycophenolic acid acyl-glucuronide metabolite

Feline Drug Metabolism and Disposition: Pharmacokinetic Evidence for Species Differences and Molecular Mechanisms

A Pharmacogenomics Primer

Canine Cytochrome P-450 Pharmacogenetics

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