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Biologically Motivated Computational Modeling of Formaldehyde Carcinogenicity in the F344 Rat

Toxicological sciences, 2003-10, Vol.75 (2), p.432-447

2003

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Human Respiratory Tract Cancer Risks of Inhaled Formaldehyde: Dose-Response Predictions Derived From Biologically-Motivated Computational Modeling of a Combined Rodent and Human Dataset

Toxicological sciences, 2004-11, Vol.82 (1), p.279-296

2004

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Dosimetry Modeling of Inhaled Formaldehyde: Binning Nasal Flux Predictions for Quantitative Risk Assessment

Toxicological sciences, 2001-11, Vol.64 (1), p.111-121

2001

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Nonmonotonic Dose-Response Relationships: Mechanistic Basis, Kinetic Modeling, and Implications for Risk Assessment

Toxicological sciences, 2004-01, Vol.77 (1), p.151-157

2004

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Transplacental and Lactational Transfer of p,p′-DDE in Sprague–Dawley Rats

Toxicology and applied pharmacology, 1999-06, Vol.157 (2), p.134-144

1999

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Biologically Motivated Quantitative Models and the Mixture Toxicity Problem

Toxicological sciences, 2001-09, Vol.63 (1), p.1-2

Conolly, R B

2001

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Dose Response for Formaldehyde-Induced Cytotoxicity in the Human Respiratory Tract

Regulatory toxicology and pharmacology, 2002-02, Vol.35 (1), p.32-43

2002

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Dose-dependent transitions in mechanisms of toxicity: case studies

Toxicology and applied pharmacology, 2004-12, Vol.201 (3), p.226-294

2004

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Dose-dependent transitions in mechanisms of toxicity

Toxicology and applied pharmacology, 2004-12, Vol.201 (3), p.203-225

2004

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A strategy for establishing mode of action of chemical carcinogens as a guide for approaches to risk assessments

Cancer letters, 1995-06, Vol.93 (1), p.129-146

1995

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Stimulating research to improve the scientific basis of risk assessment

Toxicological sciences, 1999-05, Vol.49 (1), p.1-4

1999

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Quantitative evaluation of alternative mechanisms of blood and testes disposition of di(2-ethylhexyl) phthalate and mono(2-ethylhexyl) phthalate in rats

Toxicological sciences, 1999-06, Vol.49 (2), p.172-185

1999

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Modeling Interindividual Variation in Physiological Factors Used in PBPK Models of Humans

Critical reviews in toxicology, 2003-01, Vol.33 (5), p.469-503

2003

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Development of a physiologically based pharmacokinetic model for chloroform

Toxicology and applied pharmacology, 1990-05, Vol.103 (3), p.512-527

1990

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Application of a physiologically based pharmacokinetic model to estimate the bioavailability of ethanol in male rats : Distinction between gastric and hepatic pathways of metabolic clearance

Toxicological sciences, 2000-06, Vol.55 (2), p.256-265

2000

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Hepatic Foci in Rats after Diethylnitrosamine Initiation and 2,3,7,8-Tetrachlorodibenzo-p-dioxin Promotion: Evaluation of a Quantitative Two-Cell Model and of CYP 1A1/1A2 as a Dosimeter

Toxicology and applied pharmacology, 1997-10, Vol.146 (2), p.281-293

1997

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Development of a Physiologically Based Pharmacokinetic Model of 2-Methoxyethanol and 2-Methoxyacetic Acid Disposition in Pregnant Rats

Toxicology and applied pharmacology, 2000-02, Vol.163 (1), p.67-74

2000

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Comparison of Inhaled Formaldehyde Dosimetry Predictions with DNA–Protein Cross-Link Measurements in the Rat Nasal Passages

Toxicology and applied pharmacology, 1997-03, Vol.143 (1), p.47-55

1997

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A Physiologically Based Pharmacodynamic Analysis of Hepatic Foci within a Medium-Term Liver Bioassay Using Pentachlorobenzene as a Promoter and Diethylnitrosamine as an Initiator

Toxicology and applied pharmacology, 2000-07, Vol.166 (2), p.128-137

2000

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New directions in incidence-dose modeling

Trends in biotechnology (Regular ed.), 2005-03, Vol.23 (3), p.122-127

2005

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Physiologically Based Pharmacokinetic Model for the Inhibition of Acetylcholinesterase by Organophosphate Esters

Environmental health perspectives, 1994-12, Vol.102 (suppl 11), p.51-60

1994

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Quantitative Evaluation of Alternative Mechanisms of Blood Disposition of Di(n-butyl) Phthalate and Mono(n-butyl) Phthalate in Rats

Toxicological sciences, 2000-02, Vol.53 (2), p.173-184

2000

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Nonlinearity and thresholds in dose–response relationships for carcinogenicity due to sampling variation, logarithmic dose scaling, or small differences in individual susceptibility

Toxicology and applied pharmacology, 2005-09, Vol.207 (2), p.565-569

2005

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Analysis of Respiratory Exchange of Methanol in the Lung of the Monkey Using a Physiological Model

Toxicological sciences, 2000-02, Vol.53 (2), p.185-193

2000

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Endocrine disrupting chemicals in fish: Developing exposure indicators and predictive models of effects based on mechanism of action

Aquatic toxicology, 2009-05, Vol.92 (3), p.168-178

2009

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Biologically Motivated Computational Modeling of Formaldehyde Carcinogenicity in the F344 Rat

Human Respiratory Tract Cancer Risks of Inhaled Formaldehyde: Dose-Response Predictions Derived From Biologically-Motivated Computational Modeling of a Combined Rodent and Human Dataset

Dosimetry Modeling of Inhaled Formaldehyde: Binning Nasal Flux Predictions for Quantitative Risk Assessment

Nonmonotonic Dose-Response Relationships: Mechanistic Basis, Kinetic Modeling, and Implications for Risk Assessment

Transplacental and Lactational Transfer of p,p′-DDE in Sprague–Dawley Rats

Biologically Motivated Quantitative Models and the Mixture Toxicity Problem

Dose Response for Formaldehyde-Induced Cytotoxicity in the Human Respiratory Tract

Dose-dependent transitions in mechanisms of toxicity: case studies

Dose-dependent transitions in mechanisms of toxicity

A strategy for establishing mode of action of chemical carcinogens as a guide for approaches to risk assessments

Stimulating research to improve the scientific basis of risk assessment

Quantitative evaluation of alternative mechanisms of blood and testes disposition of di(2-ethylhexyl) phthalate and mono(2-ethylhexyl) phthalate in rats

Modeling Interindividual Variation in Physiological Factors Used in PBPK Models of Humans

Development of a physiologically based pharmacokinetic model for chloroform

Application of a physiologically based pharmacokinetic model to estimate the bioavailability of ethanol in male rats : Distinction between gastric and hepatic pathways of metabolic clearance

Hepatic Foci in Rats after Diethylnitrosamine Initiation and 2,3,7,8-Tetrachlorodibenzo-p-dioxin Promotion: Evaluation of a Quantitative Two-Cell Model and of CYP 1A1/1A2 as a Dosimeter

Development of a Physiologically Based Pharmacokinetic Model of 2-Methoxyethanol and 2-Methoxyacetic Acid Disposition in Pregnant Rats

Comparison of Inhaled Formaldehyde Dosimetry Predictions with DNA–Protein Cross-Link Measurements in the Rat Nasal Passages

A Physiologically Based Pharmacodynamic Analysis of Hepatic Foci within a Medium-Term Liver Bioassay Using Pentachlorobenzene as a Promoter and Diethylnitrosamine as an Initiator

New directions in incidence-dose modeling

Physiologically Based Pharmacokinetic Model for the Inhibition of Acetylcholinesterase by Organophosphate Esters

Quantitative Evaluation of Alternative Mechanisms of Blood Disposition of Di(n-butyl) Phthalate and Mono(n-butyl) Phthalate in Rats

Nonlinearity and thresholds in dose–response relationships for carcinogenicity due to sampling variation, logarithmic dose scaling, or small differences in individual susceptibility

Analysis of Respiratory Exchange of Methanol in the Lung of the Monkey Using a Physiological Model

Endocrine disrupting chemicals in fish: Developing exposure indicators and predictive models of effects based on mechanism of action

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