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Screening and Development of New Inhibitors of FtsZ from M. Tuberculosis

PloS one, 2016-10, Vol.11 (10), p.e0164100

2016

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Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation

Journal of medicinal chemistry, 2018-04, Vol.61 (7), p.2694-2706

2018

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Antitrypanosomal Chloronitrobenzamides

Journal of medicinal chemistry, 2024-03, Vol.67 (5), p.3437-3447

2024

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Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation

Journal of medicinal chemistry, 2018-04, Vol.61 (7), p.2680-2693

2018

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Discovery of Novel Antimalarial Compounds Enabled by QSAR-Based Virtual Screening

Journal of chemical information and modeling, 2013-02, Vol.53 (2), p.475-492

2013

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Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase

Nature chemical biology, 2017-08, Vol.13 (8), p.850

2017

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Diverse amide analogs of sulindac for cancer treatment and prevention

Bioorganic & medicinal chemistry letters, 2017-10, Vol.27 (20), p.4614-4621

2017

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A small diversity library of α-methyl amide analogs of sulindac for probing anticancer structure-activity relationships

Bioorganic & medicinal chemistry letters, 2018-07, Vol.28 (12), p.2136-2142

2018

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Lead Optimization of 3-Carboxyl-4(1H)-Quinolones to Deliver Orally Bioavailable Antimalarials

Journal of medicinal chemistry, 2012-05, Vol.55 (9), p.4205-4219

2012

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Optimization of a Novel Series of Ataxia-Telangiectasia Mutated Kinase Inhibitors as Potential Radiosensitizing Agents

Journal of medicinal chemistry, 2016-01, Vol.59 (2), p.559-577

2016

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Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1+/−p53−/− mice

Cancer cell, 2004-09, Vol.6 (3), p.229-240

2004

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Potent Plasmodium falciparum gametocytocidal activity of diaminonaphthoquinones, lead antimalarial chemotypes identified in an antimalarial compound screen

Antimicrobial agents and chemotherapy, 2015-03, Vol.59 (3), p.1389-1397

2015

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Antimalarial evaluation of the chemical constituents of hairy root culture of Bixa orellana L

Molecules (Basel, Switzerland), 2014-01, Vol.19 (1), p.756-766

2014

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MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs

Nature medicine, 1999-09, Vol.5 (9), p.1048-1051

1999

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Oxazole and thiazole analogs of sulindac for cancer prevention

Future medicinal chemistry, 2018-04, Vol.10 (7), p.743-753

2018

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Optimization of the electrophile of chloronitrobenzamide leads active against Trypanosoma brucei

Bioorganic & medicinal chemistry letters, 2013-07, Vol.23 (14), p.4127-4131

2013

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Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors

Bioorganic & medicinal chemistry, 2018-01, Vol.26 (1), p.25-36

2018

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Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening

PLoS neglected tropical diseases, 2017-12, Vol.11 (12), p.e0006157

2017

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Dihydroquinazolinone Inhibitors of Proliferation of Blood and Liver Stage Malaria Parasites

Antimicrobial Agents and Chemotherapy, 2014-03, Vol.58 (3), p.1516-1522

2014

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Identification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds

PloS one, 2015-04, Vol.10 (4), p.e0123598

2015

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Synthesis and Evaluation of 7-Substituted 4-Aminoquinoline Analogues for Antimalarial Activity

Journal of medicinal chemistry, 2011-10, Vol.54 (20), p.7084-7093

2011

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Optimization of Chloronitrobenzamides (CNBs) as Therapeutic Leads for Human African Trypanosomiasis (HAT)

Journal of medicinal chemistry, 2013-04, Vol.56 (7), p.2850-2860

2013

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Synthesis and Evaluation of Sulfonylnitrophenylthiazoles (SNPTs) as Thyroid Hormone Receptor–Coactivator Interaction Inhibitors

Journal of medicinal chemistry, 2012-03, Vol.55 (5), p.2301-2310

2012

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Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway

Bioorganic & medicinal chemistry, 2010-07, Vol.18 (13), p.4801-4811

2010

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Mouse embryos cloned from brain tumors

Cancer research (Chicago, Ill.), 2003-06, Vol.63 (11), p.2733-2736

2003

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Screening and Development of New Inhibitors of FtsZ from M. Tuberculosis

Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation

Antitrypanosomal Chloronitrobenzamides

Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation

Discovery of Novel Antimalarial Compounds Enabled by QSAR-Based Virtual Screening

Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase

Diverse amide analogs of sulindac for cancer treatment and prevention

A small diversity library of α-methyl amide analogs of sulindac for probing anticancer structure-activity relationships

Lead Optimization of 3-Carboxyl-4(1H)-Quinolones to Deliver Orally Bioavailable Antimalarials

Optimization of a Novel Series of Ataxia-Telangiectasia Mutated Kinase Inhibitors as Potential Radiosensitizing Agents

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1+/−p53−/− mice

Potent Plasmodium falciparum gametocytocidal activity of diaminonaphthoquinones, lead antimalarial chemotypes identified in an antimalarial compound screen

Antimalarial evaluation of the chemical constituents of hairy root culture of Bixa orellana L

MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs

Oxazole and thiazole analogs of sulindac for cancer prevention

Optimization of the electrophile of chloronitrobenzamide leads active against Trypanosoma brucei

Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors

Discovery of novel, orally bioavailable, antileishmanial compounds using phenotypic screening

Dihydroquinazolinone Inhibitors of Proliferation of Blood and Liver Stage Malaria Parasites

Identification of Selective Inhibitors of the Plasmodium falciparum Hexose Transporter PfHT by Screening Focused Libraries of Anti-Malarial Compounds

Synthesis and Evaluation of 7-Substituted 4-Aminoquinoline Analogues for Antimalarial Activity

Optimization of Chloronitrobenzamides (CNBs) as Therapeutic Leads for Human African Trypanosomiasis (HAT)

Synthesis and Evaluation of Sulfonylnitrophenylthiazoles (SNPTs) as Thyroid Hormone Receptor–Coactivator Interaction Inhibitors

Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway

Mouse embryos cloned from brain tumors

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