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Striking Effect of Hydroxamic Acid Substitution on the Phosphodiesterase Type 4 (PDE4) and TNFα Inhibitory Activity of Two Series of Rolipram Analogues: Implications for a New Active Site Model of PDE4

Journal of medicinal chemistry, 1998-01, Vol.41 (3), p.266-270

1998

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Pim Serine/Threonine Kinases Regulate the Stability of Socs-1 Protein

Proceedings of the National Academy of Sciences - PNAS, 2002-02, Vol.99 (4), p.2175-2180

2002

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Purification and characterization of human skin mast cells. Evidence for human mast cell heterogeneity

The Journal of immunology (1950), 1987-11, Vol.139 (9), p.3062-3069

1987

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In vitro pharmacology of the novel phosphodiesterase type 4 inhibitor, CP-80633

The Journal of pharmacology and experimental therapeutics, 1996-09, Vol.278 (3), p.1356

1996

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Human uterine mast cells. Isolation, purification, characterization, ultrastructure, and pharmacology

The Journal of immunology (1950), 1991-09, Vol.147 (5), p.1621-1627

1991

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Antigen-mediated pulmonary eosinophilia in immunoglobulin G1-sensitized guinea pigs: eosinophil peroxidase as a simple specific marker for detecting eosinophils in bronchoalveolar lavage fluid

The Journal of pharmacology and experimental therapeutics, 1993-02, Vol.264 (2), p.922

1993

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The in vivo pharmacology of CP-80, 633, a selective inhibitor of phosphodiesterase 4

The Journal of pharmacology and experimental therapeutics, 1996-09, Vol.278 (3), p.1349

1996

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Production and characterization of guinea pig IL-5 in baculovirus-infected insect cells

American journal of physiology. Lung cellular and molecular physiology, 1996-06, Vol.270 (6), p.1002-L1007

1996

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Interleukin-1 is a mucus secretagogue

Cellular immunology, 1991-09, Vol.136 (2), p.425-434

1991

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Protein kinase C modulates immunoglobulin E-mediated activation of human mast cells from lung and skin. I. Pharmacologic inhibition

The Journal of pharmacology and experimental therapeutics, 1991-09, Vol.258 (3), p.824

1991

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Induction of histamine release from human skin mast cells by bradykinin analogs

Biochemical pharmacology, 1989-01, Vol.38 (2), p.227-233

1989

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Mechanisms of mediator release from human skin mast cells upon stimulation by the bradykinin analog, [ dArg 0-Hyp 3- dPhe 7]bradykinin

Biochemical pharmacology, 1991-01, Vol.41 (2), p.293-300

1991

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7-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridines as Novel Inhibitors of Human Eosinophil Phosphodiesterase

Journal of medicinal chemistry, 1998-06, Vol.41 (13), p.2268-2277

1998

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The phosphodiesterase type 4 (PDE4) inhibitor CP-80,633 elevates plasma cyclic AMP levels and decreases tumor necrosis factor-alpha (TNFalpha) production in mice: effect of adrenalectomy

The Journal of pharmacology and experimental therapeutics, 1997-02, Vol.280 (2), p.621

1997

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H-2 negative teratocarcinoma cells become H-2 positive when passaged in genetically resistant host mice

The Journal of immunology (1950), 1981-06, Vol.126 (6), p.2190-2193

1981

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Differential in vivo and in vitro bronchorelaxant activities of CP-80,633, a selective phosphodiesterase 4 inhibitor

Canadian journal of physiology and pharmacology, 1997-08, Vol.75 (8), p.1001-1008

1997

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Multiple antigen challenge produces pulmonary eosinophilia but not pulmonary hyperresponsiveness in actively sensitized guinea pigs

Agents and Actions, 1992-11, Vol.37 (3-4), p.174-177

1992

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Biarylcarboxamide inhibitors of phosphodiesterase IV and tumor necrosis factor-α

Bioorganic & medicinal chemistry letters, 1997-03, Vol.7 (6), p.739-744

1997

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Dexamethasone does not inhibit the release of mediators from human mast cells residing in airway, intestine, or skin

The American review of respiratory disease, 1989-10, Vol.140 (4), p.951-954

1989

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Bradykinin analog induce histamine release from human skin mast cells

Advances in experimental medicine and biology, 1989, Vol.247A, p.225

1989

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7-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine as novel inhibitors of human eosinophil phosphodiesterase

Journal of medicinal chemistry, 1998, Vol.41 (13), p.2268-2277

1998

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Synthesis and pharmacological profile of two novel heterocyclic chromanols, CP-80,798 and CP-85,958, as potent LTD4 receptor antagonists

Bioorganic & medicinal chemistry letters, 1995-07, Vol.5 (13), p.1365-1370

1995

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Production and characterization of guinea pig IL-5 in baculovirus-infected insect cells

American journal of physiology. Lung cellular and molecular physiology, 1996-06, Vol.14 (6), p.L1002-L1007

1996

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Mechanisms of mediator release from human skin mast cells upon stimulation by the bradykinin analog, (DArg super(0)-Hyp super(3)-DPhe super(7))bradykinin

Biochemical pharmacology, 1991-01, Vol.41 (2), p.293-300

1991

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ChemInform Abstract: Biarylcarboxamide Inhibitors of Phosphodiesterase IV and Tumor Necrosis Factor-α

ChemInform, 1997-07, Vol.28 (29), p.no-no

1997

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Striking Effect of Hydroxamic Acid Substitution on the Phosphodiesterase Type 4 (PDE4) and TNFα Inhibitory Activity of Two Series of Rolipram Analogues: Implications for a New Active Site Model of PDE4

Pim Serine/Threonine Kinases Regulate the Stability of Socs-1 Protein

Purification and characterization of human skin mast cells. Evidence for human mast cell heterogeneity

In vitro pharmacology of the novel phosphodiesterase type 4 inhibitor, CP-80633

Human uterine mast cells. Isolation, purification, characterization, ultrastructure, and pharmacology

Antigen-mediated pulmonary eosinophilia in immunoglobulin G1-sensitized guinea pigs: eosinophil peroxidase as a simple specific marker for detecting eosinophils in bronchoalveolar lavage fluid

The in vivo pharmacology of CP-80, 633, a selective inhibitor of phosphodiesterase 4

Production and characterization of guinea pig IL-5 in baculovirus-infected insect cells

Interleukin-1 is a mucus secretagogue

Protein kinase C modulates immunoglobulin E-mediated activation of human mast cells from lung and skin. I. Pharmacologic inhibition

Induction of histamine release from human skin mast cells by bradykinin analogs

Mechanisms of mediator release from human skin mast cells upon stimulation by the bradykinin analog, [ dArg 0-Hyp 3- dPhe 7]bradykinin

7-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridines as Novel Inhibitors of Human Eosinophil Phosphodiesterase

The phosphodiesterase type 4 (PDE4) inhibitor CP-80,633 elevates plasma cyclic AMP levels and decreases tumor necrosis factor-alpha (TNFalpha) production in mice: effect of adrenalectomy

H-2 negative teratocarcinoma cells become H-2 positive when passaged in genetically resistant host mice

Differential in vivo and in vitro bronchorelaxant activities of CP-80,633, a selective phosphodiesterase 4 inhibitor

Multiple antigen challenge produces pulmonary eosinophilia but not pulmonary hyperresponsiveness in actively sensitized guinea pigs

Biarylcarboxamide inhibitors of phosphodiesterase IV and tumor necrosis factor-α

Dexamethasone does not inhibit the release of mediators from human mast cells residing in airway, intestine, or skin

Bradykinin analog induce histamine release from human skin mast cells

7-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine as novel inhibitors of human eosinophil phosphodiesterase

Synthesis and pharmacological profile of two novel heterocyclic chromanols, CP-80,798 and CP-85,958, as potent LTD4 receptor antagonists

Production and characterization of guinea pig IL-5 in baculovirus-infected insect cells

Mechanisms of mediator release from human skin mast cells upon stimulation by the bradykinin analog, (DArg super(0)-Hyp super(3)-DPhe super(7))bradykinin

ChemInform Abstract: Biarylcarboxamide Inhibitors of Phosphodiesterase IV and Tumor Necrosis Factor-α

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