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Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection

Bioorganic & medicinal chemistry letters, 2019-08, Vol.29 (15), p.1874-1880

2019

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Structural Analysis of the Complex of Human Transthyretin with 3′,5′-Dichlorophenylanthranilic Acid at 1.5 Å Resolution

Molecules (Basel, Switzerland), 2022-10, Vol.27 (21), p.7206

2022

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Three-Dimensional Modeling of Thyroid Hormone Metabolites Binding to the Cancer-Relevant αvβ3 Integrin: In-Silico Based Study

Frontiers in endocrinology (Lausanne), 2022-05, Vol.13, p.895240-895240

2022

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Structural Analysis of Dihydrofolate Reductase and Thymidylate Synthase from Mammalian and Pathogenic Organisms

Current enzyme inhibition, 2012-09, Vol.8 (2), p.124-139

Cody, Vivian

2012

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Chemically Self-Assembled Antibody Nanorings (CSANs): Design and Characterization of an Anti-CD3 IgM Biomimetic

Journal of the American Chemical Society, 2010-12, Vol.132 (48), p.17247-17257

2010

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Structural analysis of Pneumocystis carinii and human DHFR complexes with NADPH and a series of five potent 6-[5′-(ω-carboxyalkoxy)benzyl]pyrido[2,3-d]pyrimidine derivatives

Acta crystallographica. Section D, Biological crystallography., 2011-01, Vol.67 (1), p.1-7

2011

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Design, Synthesis, and X-ray Crystal Structure of a Potent Dual Inhibitor of Thymidylate Synthase and Dihydrofolate Reductase as an Antitumor Agent

Journal of medicinal chemistry, 2000-10, Vol.43 (21), p.3837-3851

2000

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Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents

Bioorganic & medicinal chemistry, 2018-05, Vol.26 (9), p.2640-2650

2018

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Design, Synthesis, and Molecular Modeling of Novel Pyrido[2,3‑d]pyrimidine Analogues As Antifolates; Application of Buchwald–Hartwig Aminations of Heterocycles

Journal of medicinal chemistry, 2013-06, Vol.56 (11), p.4422-4441

2013

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Membrane receptors mediating thyroid hormone action

Trends in endocrinology and metabolism, 2005-11, Vol.16 (9), p.429-435

2005

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Molecular modeling of the thyroid hormone interactions with alpha v beta 3 integrin

Steroids, 2007-02, Vol.72 (2), p.165

2007

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Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH

Acta crystallographica. Section D, Biological crystallography., 2005-02, Vol.61 (2), p.147-155

2005

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Kinetic and Structural Analysis for Potent Antifolate Inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and Human Dihydrofolate Reductases and Their Active-Site Variants

Antimicrobial agents and chemotherapy, 2013-06, Vol.57 (6), p.2669-2677

2013

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Design, Synthesis, and X-ray Crystal Structure of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumor Agents

Journal of medicinal chemistry, 2009-08, Vol.52 (15), p.4892-4902

2009

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A novel mutation in the Albumin gene (R218S) causing familial dysalbuminemic hyperthyroxinemia in a family of Bangladeshi extraction

Thyroid (New York, N.Y.), 2014-06, Vol.24 (6), p.945-950

2014

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Isolation of Rat Dihydrofolate Reductase Gene and Characterization of Recombinant Enzyme

Antimicrobial Agents and Chemotherapy, 2001-09, Vol.45 (9), p.2517-2523

2001

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Molecular modeling of the thyroid hormone interactions with αvβ3 integrin

Steroids, 2007-02, Vol.72 (2), p.165-170

2007

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Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase

Journal of structural biology, 2011-10, Vol.176 (1), p.52-59

2011

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Structure-activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase

Acta crystallographica. Section F, Structural biology communications, 2015-06, Vol.71 (6), p.799-803

2015

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Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3- d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors

Bioorganic & medicinal chemistry, 2011-06, Vol.19 (11), p.3585-3594

2011

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New insights into DHFR interactions: Analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(ω-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions

Proteins, structure, function, and bioinformatics, 2006-12, Vol.65 (4), p.959-969

2006

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Probing the Impact of the echinT C-Terminal Domain on Structure and Catalysis

Journal of molecular biology, 2010-12, Vol.404 (4), p.627-638

2010

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Correlations of Inhibitor Kinetics for Pneumocystis jirovecii and Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes

Biochemistry (Easton), 2009-03, Vol.48 (8), p.1702-1711

2009

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Abstract 2676: Unusual binding of TMP in two different sites in the binary complex with the Q35S/N64F double mutant of human dihydrofolate reductase

Cancer research (Chicago, Ill.), 2010-04, Vol.70 (8_Supplement), p.2676-2676

2010

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Conformational analysis of flavonoids: crystal and molecular structures of morin hydrate and myricetin (1:2) triphenylphosphine oxide complex

Journal of molecular structure, 1994-01, Vol.317 (1), p.89-97

1994

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Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection

Structural Analysis of the Complex of Human Transthyretin with 3′,5′-Dichlorophenylanthranilic Acid at 1.5 Å Resolution

Three-Dimensional Modeling of Thyroid Hormone Metabolites Binding to the Cancer-Relevant αvβ3 Integrin: In-Silico Based Study

Structural Analysis of Dihydrofolate Reductase and Thymidylate Synthase from Mammalian and Pathogenic Organisms

Chemically Self-Assembled Antibody Nanorings (CSANs): Design and Characterization of an Anti-CD3 IgM Biomimetic

Structural analysis of Pneumocystis carinii and human DHFR complexes with NADPH and a series of five potent 6-[5′-(ω-carboxyalkoxy)benzyl]pyrido[2,3-d]pyrimidine derivatives

Design, Synthesis, and X-ray Crystal Structure of a Potent Dual Inhibitor of Thymidylate Synthase and Dihydrofolate Reductase as an Antitumor Agent

Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents

Design, Synthesis, and Molecular Modeling of Novel Pyrido[2,3‑d]pyrimidine Analogues As Antifolates; Application of Buchwald–Hartwig Aminations of Heterocycles

Membrane receptors mediating thyroid hormone action

Molecular modeling of the thyroid hormone interactions with alpha v beta 3 integrin

Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH

Kinetic and Structural Analysis for Potent Antifolate Inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and Human Dihydrofolate Reductases and Their Active-Site Variants

Design, Synthesis, and X-ray Crystal Structure of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumor Agents

A novel mutation in the Albumin gene (R218S) causing familial dysalbuminemic hyperthyroxinemia in a family of Bangladeshi extraction

Isolation of Rat Dihydrofolate Reductase Gene and Characterization of Recombinant Enzyme

Molecular modeling of the thyroid hormone interactions with αvβ3 integrin

Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase

Structure-activity correlations for three pyrido[2,3-d]pyrimidine antifolates binding to human and Pneumocystis carinii dihydrofolate reductase

Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3- d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors

New insights into DHFR interactions: Analysis of Pneumocystis carinii and mouse DHFR complexes with NADPH and two highly potent 5-(ω-carboxy(alkyloxy) trimethoprim derivatives reveals conformational correlations with activity and novel parallel ring stacking interactions

Probing the Impact of the echinT C-Terminal Domain on Structure and Catalysis

Correlations of Inhibitor Kinetics for Pneumocystis jirovecii and Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes

Abstract 2676: Unusual binding of TMP in two different sites in the binary complex with the Q35S/N64F double mutant of human dihydrofolate reductase

Conformational analysis of flavonoids: crystal and molecular structures of morin hydrate and myricetin (1:2) triphenylphosphine oxide complex

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