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Atomic Structure of T6SS Reveals Interlaced Array Essential to Function

Cell, 2015-02, Vol.160 (5), p.940-951

2015

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Targeted Intracellular Delivery of Antituberculosis Drugs to Mycobacterium tuberculosis-Infected Macrophages via Functionalized Mesoporous Silica Nanoparticles

Antimicrobial Agents and Chemotherapy, 2012-05, Vol.56 (5), p.2535-2545

2012

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Output-driven feedback system control platform optimizes combinatorial therapy of tuberculosis using a macrophage cell culture model

Proceedings of the National Academy of Sciences - PNAS, 2016-04, Vol.113 (15), p.E2172-E2179

2016

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Artificial intelligence enabled parabolic response surface platform identifies ultra-rapid near-universal TB drug treatment regimens comprising approved drugs

PloS one, 2019-05, Vol.14 (5), p.e0215607-e0215607

2019

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The Francisella Type VI Secretion System

Frontiers in cellular and infection microbiology, 2018-04, Vol.8, p.121-121

2018

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Drug regimens identified and optimized by output-driven platform markedly reduce tuberculosis treatment time

Nature communications, 2017-01, Vol.8 (1), p.14183-14183, Article 14183

2017

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Intracellular Photothermal Delivery for Suspension Cells Using Sharp Nanoscale Tips in Microwells

ACS nano, 2019-09, Vol.13 (9), p.10835-10844

2019

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Ultra-rapid near universal TB drug regimen identified via parabolic response surface platform cures mice of both conventional and high susceptibility

PloS one, 2018-11, Vol.13 (11), p.e0207469-e0207469

2018

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Virulent and Avirulent Strains of Francisella tularensis Prevent Acidification and Maturation of Their Phagosomes and Escape into the Cytoplasm in Human Macrophages

Infection and Immunity, 2004-06, Vol.72 (6), p.3204-3217

2004

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Atomic Structure of IglD Demonstrates Its Role as a Component of the Baseplate Complex of the Francisella Type VI Secretion System

mBio, 2022-10, Vol.13 (5), p.e0127722

2022

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Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses

Proceedings of the National Academy of Sciences - PNAS, 2013-12, Vol.110 (50), p.E4904-E4912

2013

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Uptake and Intracellular Fate of Francisella tularensis in Human Macrophages

Annals of the New York Academy of Sciences, 2007-06, Vol.1105 (1), p.160-186

2007

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Francisella tularensis Enters Macrophages via a Novel Process Involving Pseudopod Loops

Infection and Immunity, 2005-09, Vol.73 (9), p.5892-5902

2005

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Francisella tularensis Phagosomal Escape Does Not Require Acidification of the Phagosome

Infection and Immunity, 2009-05, Vol.77 (5), p.1757-1773

2009

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Efficacy and safety of an innovative short-course regimen containing clofazimine for treatment of drug-susceptible tuberculosis: a clinical trial

Emerging microbes & infections, 2023-12, Vol.12 (1), p.2187247-2187247

2023

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O-Antigen-Deficient Francisella tularensis Live Vaccine Strain Mutants Are Ingested via an Aberrant Form of Looping Phagocytosis and Show Altered Kinetics of Intracellular Trafficking in Human Macrophages

Infection and Immunity, 2012-03, Vol.80 (3), p.952-967

2012

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Mesoporous Silica Nanoparticles with pH-Sensitive Nanovalves for Delivery of Moxifloxacin Provide Improved Treatment of Lethal Pneumonic Tularemia

ACS nano, 2015-11, Vol.9 (11), p.10778-10789

2015

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Identification, Recombinant Expression, Immunolocalization in Macrophages, and T-Cell Responsiveness of the Major Extracellular Proteins of Francisella tularensis

Infection and Immunity, 2006-07, Vol.74 (7), p.4002-4013

2006

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Massively parallel delivery of large cargo into mammalian cells with light pulses

Nature methods, 2015-05, Vol.12 (5), p.439-444

2015

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Facile Strategy Enabling Both High Loading and High Release Amounts of the Water-Insoluble Drug Clofazimine Using Mesoporous Silica Nanoparticles

ACS applied materials & interfaces, 2018-09, Vol.10 (38), p.31870-31881

2018

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A Pathogen-Specific Cargo Delivery Platform Based on Mesoporous Silica Nanoparticles

Journal of the American Chemical Society, 2017-05, Vol.139 (19), p.6663-6668

2017

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Redox-Triggered Release of Moxifloxacin from Mesoporous Silica Nanoparticles Functionalized with Disulfide Snap-Tops Enhances Efficacy Against Pneumonic Tularemia in Mice

Small (Weinheim an der Bergstrasse, Germany), 2016-07, Vol.12 (27), p.3690-3702

2016

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pH-Responsive Isoniazid-Loaded Nanoparticles Markedly Improve Tuberculosis Treatment in Mice

Small (Weinheim an der Bergstrasse, Germany), 2015-10, Vol.11 (38), p.5066-5078

2015

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In vivo radiometric analysis of glucose uptake and distribution in mouse bone

Bone Research, 2016-04, Vol.4 (1), p.31-38, Article 16004

2016

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Atomic Structure of the Francisella T6SS Central Spike Reveals a Unique α-Helical Lid and a Putative Cargo

Structure (London), 2019-12, Vol.27 (12), p.1811-1819.e6

2019

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Atomic Structure of T6SS Reveals Interlaced Array Essential to Function

Targeted Intracellular Delivery of Antituberculosis Drugs to Mycobacterium tuberculosis-Infected Macrophages via Functionalized Mesoporous Silica Nanoparticles

Output-driven feedback system control platform optimizes combinatorial therapy of tuberculosis using a macrophage cell culture model

Artificial intelligence enabled parabolic response surface platform identifies ultra-rapid near-universal TB drug treatment regimens comprising approved drugs

The Francisella Type VI Secretion System

Drug regimens identified and optimized by output-driven platform markedly reduce tuberculosis treatment time

Intracellular Photothermal Delivery for Suspension Cells Using Sharp Nanoscale Tips in Microwells

Ultra-rapid near universal TB drug regimen identified via parabolic response surface platform cures mice of both conventional and high susceptibility

Virulent and Avirulent Strains of Francisella tularensis Prevent Acidification and Maturation of Their Phagosomes and Escape into the Cytoplasm in Human Macrophages

Atomic Structure of IglD Demonstrates Its Role as a Component of the Baseplate Complex of the Francisella Type VI Secretion System

Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses

Uptake and Intracellular Fate of Francisella tularensis in Human Macrophages

Francisella tularensis Enters Macrophages via a Novel Process Involving Pseudopod Loops

Francisella tularensis Phagosomal Escape Does Not Require Acidification of the Phagosome

Efficacy and safety of an innovative short-course regimen containing clofazimine for treatment of drug-susceptible tuberculosis: a clinical trial

O-Antigen-Deficient Francisella tularensis Live Vaccine Strain Mutants Are Ingested via an Aberrant Form of Looping Phagocytosis and Show Altered Kinetics of Intracellular Trafficking in Human Macrophages

Mesoporous Silica Nanoparticles with pH-Sensitive Nanovalves for Delivery of Moxifloxacin Provide Improved Treatment of Lethal Pneumonic Tularemia

Identification, Recombinant Expression, Immunolocalization in Macrophages, and T-Cell Responsiveness of the Major Extracellular Proteins of Francisella tularensis

Massively parallel delivery of large cargo into mammalian cells with light pulses

Facile Strategy Enabling Both High Loading and High Release Amounts of the Water-Insoluble Drug Clofazimine Using Mesoporous Silica Nanoparticles

A Pathogen-Specific Cargo Delivery Platform Based on Mesoporous Silica Nanoparticles

Redox-Triggered Release of Moxifloxacin from Mesoporous Silica Nanoparticles Functionalized with Disulfide Snap-Tops Enhances Efficacy Against Pneumonic Tularemia in Mice

pH-Responsive Isoniazid-Loaded Nanoparticles Markedly Improve Tuberculosis Treatment in Mice

In vivo radiometric analysis of glucose uptake and distribution in mouse bone

Atomic Structure of the Francisella T6SS Central Spike Reveals a Unique α-Helical Lid and a Putative Cargo

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