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Clinical development of the oral gonadotropin-releasing hormone antagonist elagolix

F&S Reports (Online), 2023-06, Vol.4 (2), p.65-72

Chwalisz, Kristof

2023

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Clinical development of the GnRH agonist leuprolide acetate depot

F&S Reports (Online), 2023-06, Vol.4 (2), p.33-39

Chwalisz, Kristof

2023

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Elagolix, an Oral GnRH Antagonist, Versus Subcutaneous Depot Medroxyprogesterone Acetate for the Treatment of Endometriosis: Effects on Bone Mineral Density

Reproductive sciences (Thousand Oaks, Calif.), 2014-11, Vol.21 (11), p.1341-1351

2014

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Elagolix for the management of heavy menstrual bleeding associated with uterine fibroids: results from a phase 2a proof-of-concept study

Fertility and sterility, 2017-07, Vol.108 (1), p.152-160.e4

2017

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A randomized, controlled trial of asoprisnil, a novel selective progesterone receptor modulator, in women with uterine leiomyomata

Fertility and sterility, 2007-06, Vol.87 (6), p.1399-1412

2007

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Current and Emerging Medical Treatments for Uterine Fibroids

Seminars in reproductive medicine, 2017-11, Vol.35 (6), p.510-522

2017

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Dose-Dependent Suppression of Gonadotropins and Ovarian Hormones by Elagolix in Healthy Premenopausal Women

The journal of clinical endocrinology and metabolism, 2017-05, Vol.102 (5), p.1683-1691

2017

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Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist

The New England journal of medicine, 2017-07, Vol.377 (1), p.28-40

2017

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Role of nonhuman primate models in the discovery and clinical development of selective progesterone receptor modulators (SPRMs)

Reproductive biology and endocrinology, 2006-10, Vol.4 Suppl 1 (S1), p.S8-S8, Article S8

2006

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Synthesis and Biological Activity of a Novel, Highly Potent Progesterone Receptor Antagonist

Journal of medicinal chemistry, 2000-12, Vol.43 (26), p.5010-5016

2000

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Long-Term Outcomes of Elagolix in Women With Endometriosis: Results From Two Extension Studies

Obstetrics and gynecology (New York. 1953), 2018-07, Vol.132 (1), p.147-160

2018

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Validation of the 4 week recall version of the Uterine Fibroid Symptom and Health-related Quality of Life (UFS-QOL) Questionnaire

Current medical research and opinion, 2017-02, Vol.33 (2), p.193-200

2017

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Selective Progesterone Receptor Modulator Development and Use in the Treatment of Leiomyomata and Endometriosis

Endocrine reviews, 2005-05, Vol.26 (3), p.423-438

2005

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Pre-eclampsia-like conditions produced by nitric oxide inhibition: effects of L-arginine, D-arginine and steroid hormones

Human reproduction (Oxford), 1995-10, Vol.10 (10), p.2723-2730

1995

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Elagolix Alone or With Add-Back Therapy in Women With Heavy Menstrual Bleeding and Uterine Leiomyomas: A Randomized Controlled Trial

Obstetrics and gynecology (New York. 1953), 2018-11, Vol.132 (5), p.1252-1264

2018

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Long-term Effect of Elagolix on Bone Mineral Density in Women with Endometriosis-Associated Pain [38G]

Obstetrics and gynecology (New York. 1953), 2018-05, Vol.131 (1), p.85-86S

2018

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Elagolix Treatment for Endometriosis-Associated Pain: Results from a Phase 2, Randomized, Double-Blind, Placebo-Controlled Study

Reproductive sciences (Thousand Oaks, Calif.), 2014-03, Vol.21 (3), p.363-371

2014

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Elagolix Suppresses Ovulation in a Dose-Dependent Manner: Results From a 3-Month, Randomized Study in Ovulatory Women

The journal of clinical endocrinology and metabolism, 2020-03, Vol.105 (3), p.821-832

2020

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Modulation of the Action of Chorionic Gonadotropin in the Baboon (Papio anubis) Uterus by a Progesterone Receptor Antagonist (ZK 137.316)

Biology of reproduction, 2000-09, Vol.63 (3), p.820-825

2000

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The Hormonal Profile of Norethindrone Acetate: Rationale for Add-Back Therapy With Gonadotropin-Releasing Hormone Agonists in Women With Endometriosis

Reproductive sciences (Thousand Oaks, Calif.), 2012-06, Vol.19 (6), p.563-571

2012

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Clinical evaluation of the oral gonadotropin-releasing hormone-antagonist elagolix for the management of endometriosis-associated pain

Pain management, 2019-09, Vol.9 (5), p.497-515

2019

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Validation of the Menstrual Pictogram in Women With Leiomyomata Associated With Heavy Menstrual Bleeding

Reproductive sciences (Thousand Oaks, Calif.), 2013-06, Vol.20 (6), p.680-687

2013

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Long-Term Safety and Efficacy of Elagolix Treatment in Women With Endometriosis-Associated Pain [11OP]

Obstetrics and gynecology (New York. 1953), 2018-05, Vol.131 (1), p.4-4S

2018

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Development and Validation of the Endometriosis Daily Pain Impact Diary Items to Assess Dysmenorrhea and Nonmenstrual Pelvic Pain

Reproductive sciences (Thousand Oaks, Calif.), 2018-11, Vol.25 (11), p.1567-1576

2018

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Characterization of the functional progesterone receptor in an endometrial adenocarcinoma cell line (Ishikawa): Progesterone-induced expression of the α1 integrin

The Journal of steroid biochemistry and molecular biology, 1996-09, Vol.59 (1), p.31-39

1996

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Clinical development of the oral gonadotropin-releasing hormone antagonist elagolix

Clinical development of the GnRH agonist leuprolide acetate depot

Elagolix, an Oral GnRH Antagonist, Versus Subcutaneous Depot Medroxyprogesterone Acetate for the Treatment of Endometriosis: Effects on Bone Mineral Density

Elagolix for the management of heavy menstrual bleeding associated with uterine fibroids: results from a phase 2a proof-of-concept study

A randomized, controlled trial of asoprisnil, a novel selective progesterone receptor modulator, in women with uterine leiomyomata

Current and Emerging Medical Treatments for Uterine Fibroids

Dose-Dependent Suppression of Gonadotropins and Ovarian Hormones by Elagolix in Healthy Premenopausal Women

Treatment of Endometriosis-Associated Pain with Elagolix, an Oral GnRH Antagonist

Role of nonhuman primate models in the discovery and clinical development of selective progesterone receptor modulators (SPRMs)

Synthesis and Biological Activity of a Novel, Highly Potent Progesterone Receptor Antagonist

Long-Term Outcomes of Elagolix in Women With Endometriosis: Results From Two Extension Studies

Validation of the 4 week recall version of the Uterine Fibroid Symptom and Health-related Quality of Life (UFS-QOL) Questionnaire

Selective Progesterone Receptor Modulator Development and Use in the Treatment of Leiomyomata and Endometriosis

Pre-eclampsia-like conditions produced by nitric oxide inhibition: effects of L-arginine, D-arginine and steroid hormones

Elagolix Alone or With Add-Back Therapy in Women With Heavy Menstrual Bleeding and Uterine Leiomyomas: A Randomized Controlled Trial

Long-term Effect of Elagolix on Bone Mineral Density in Women with Endometriosis-Associated Pain [38G]

Elagolix Treatment for Endometriosis-Associated Pain: Results from a Phase 2, Randomized, Double-Blind, Placebo-Controlled Study

Elagolix Suppresses Ovulation in a Dose-Dependent Manner: Results From a 3-Month, Randomized Study in Ovulatory Women

Modulation of the Action of Chorionic Gonadotropin in the Baboon (Papio anubis) Uterus by a Progesterone Receptor Antagonist (ZK 137.316)

The Hormonal Profile of Norethindrone Acetate: Rationale for Add-Back Therapy With Gonadotropin-Releasing Hormone Agonists in Women With Endometriosis

Clinical evaluation of the oral gonadotropin-releasing hormone-antagonist elagolix for the management of endometriosis-associated pain

Validation of the Menstrual Pictogram in Women With Leiomyomata Associated With Heavy Menstrual Bleeding

Long-Term Safety and Efficacy of Elagolix Treatment in Women With Endometriosis-Associated Pain [11OP]

Development and Validation of the Endometriosis Daily Pain Impact Diary Items to Assess Dysmenorrhea and Nonmenstrual Pelvic Pain

Characterization of the functional progesterone receptor in an endometrial adenocarcinoma cell line (Ishikawa): Progesterone-induced expression of the α1 integrin

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