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GRK5 is a regulator of fibroblast activation and cardiac fibrosis

Proceedings of the National Academy of Sciences - PNAS, 2021-02, Vol.118 (5)

2021

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Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction

Science translational medicine, 2015-03, Vol.7 (277), p.277ra31

2015

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SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore

Molecular cell, 2015-10, Vol.60 (1), p.47-62

2015

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The evolving impact of g protein-coupled receptor kinases in cardiac health and disease

Physiological reviews, 2015-04, Vol.95 (2), p.377-404

2015

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A Novel and Efficient Model of Coronary Artery Ligation and Myocardial Infarction in the Mouse

Circulation research, 2010-12, Vol.107 (12), p.1445-1453

2010

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Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity

Proceedings of the National Academy of Sciences - PNAS, 2017-01, Vol.114 (5), p.E859-E868

2017

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Restricting mitochondrial GRK2 post-ischemia confers cardioprotection by reducing myocyte death and maintaining glucose oxidation

Science signaling, 2018-12, Vol.11 (560)

2018

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Prodeath Signaling of G Protein–Coupled Receptor Kinase 2 in Cardiac Myocytes After Ischemic Stress Occurs Via Extracellular Signal–Regulated Kinase-Dependent Heat Shock Protein 90–Mediated Mitochondrial Targeting

Circulation research, 2013-04, Vol.112 (8), p.1121-1134

2013

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GRK5-Mediated Exacerbation of Pathological Cardiac Hypertrophy Involves Facilitation of Nuclear NFAT Activity

Circulation research, 2014-12, Vol.115 (12), p.976-985

2014

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Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process

PloS one, 2013-03, Vol.8 (3), p.e57324-e57324

2013

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Paroxetine Is a Direct Inhibitor of G Protein-Coupled Receptor Kinase 2 and Increases Myocardial Contractility

ACS chemical biology, 2012-11, Vol.7 (11), p.1830-1839

2012

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G Protein-Coupled Receptor Kinase 2 Activity Impairs Cardiac Glucose Uptake and Promotes Insulin Resistance After Myocardial Ischemia

Circulation (New York, N.Y.), 2011-05, Vol.123 (18), p.1953-1962

2011

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GRK2 in the heart: a GPCR kinase and beyond

Antioxidants & redox signaling, 2014-11, Vol.21 (14), p.2032

2014

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Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic functional heart failure rescue

Circulation (New York, N.Y.), 2007-05, Vol.115 (19), p.2506-2515

2007

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Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes

Proceedings of the National Academy of Sciences - PNAS, 2008-08, Vol.105 (34), p.12457-12462

2008

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Gi-Biased β2AR Signaling Links GRK2 Upregulation to Heart Failure

Circulation research, 2012-01, Vol.110 (2), p.265-274

2012

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Myocardial Ablation of G Protein-Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway

PloS one, 2013-06, Vol.8 (6), p.e66234-e66234

2013

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Level of G protein–Coupled Receptor Kinase-2 Determines Myocardial Ischemia/Reperfusion Injury via Pro- and Anti-Apoptotic Mechanisms

Circulation research, 2010-10, Vol.107 (9), p.1140-1149

2010

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Convergence of G protein-coupled receptor and S-nitrosylation signaling determines the outcome to cardiac ischemic injury

Science signaling, 2013-10, Vol.6 (299), p.ra95

2013

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Differential Role of G Protein–Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy

Circulation research, 2015-12, Vol.117 (12), p.1001-1012

2015

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Inhibition of Fas-associated death domain-containing protein (FADD) protects against myocardial ischemia/reperfusion injury in a heart failure mouse model

PloS one, 2013-09, Vol.8 (9), p.e73537-e73537

2013

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In Vivo Stimulation of α- and β-Adrenoceptors in Mice Differentially Alters Small RNA Content of Circulating Extracellular Vesicles

Cells (Basel, Switzerland), 2021-05, Vol.10 (5), p.1211

2021

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Targeted Inhibition of Cardiomyocyte Gi Signaling Enhances Susceptibility to Apoptotic Cell Death in Response to Ischemic Stress

Circulation (New York, N.Y.), 2008-03, Vol.117 (11), p.1378-1387

2008

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Darbepoetin alfa, a long-acting erythropoietin analog, offers novel and delayed cardioprotection for the ischemic heart

American journal of physiology. Heart and circulatory physiology, 2007-07, Vol.293 (1), p.H60-H68

2007

Volltextzugriff (PDF)

Characterization of βARKct engineered cellular extracellular vesicles and model specific cardioprotection

American journal of physiology. Heart and circulatory physiology, 2021-04, Vol.320 (4), p.H1276-H1289

2021

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GRK5 is a regulator of fibroblast activation and cardiac fibrosis

Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction

SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore

The evolving impact of g protein-coupled receptor kinases in cardiac health and disease

A Novel and Efficient Model of Coronary Artery Ligation and Myocardial Infarction in the Mouse

Mitochondrial fusion dynamics is robust in the heart and depends on calcium oscillations and contractile activity

Restricting mitochondrial GRK2 post-ischemia confers cardioprotection by reducing myocyte death and maintaining glucose oxidation

Prodeath Signaling of G Protein–Coupled Receptor Kinase 2 in Cardiac Myocytes After Ischemic Stress Occurs Via Extracellular Signal–Regulated Kinase-Dependent Heat Shock Protein 90–Mediated Mitochondrial Targeting

GRK5-Mediated Exacerbation of Pathological Cardiac Hypertrophy Involves Facilitation of Nuclear NFAT Activity

Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process

Paroxetine Is a Direct Inhibitor of G Protein-Coupled Receptor Kinase 2 and Increases Myocardial Contractility

G Protein-Coupled Receptor Kinase 2 Activity Impairs Cardiac Glucose Uptake and Promotes Insulin Resistance After Myocardial Ischemia

GRK2 in the heart: a GPCR kinase and beyond

Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic functional heart failure rescue

Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes

Gi-Biased β2AR Signaling Links GRK2 Upregulation to Heart Failure

Myocardial Ablation of G Protein-Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway

Level of G protein–Coupled Receptor Kinase-2 Determines Myocardial Ischemia/Reperfusion Injury via Pro- and Anti-Apoptotic Mechanisms

Convergence of G protein-coupled receptor and S-nitrosylation signaling determines the outcome to cardiac ischemic injury

Differential Role of G Protein–Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy

Inhibition of Fas-associated death domain-containing protein (FADD) protects against myocardial ischemia/reperfusion injury in a heart failure mouse model

In Vivo Stimulation of α- and β-Adrenoceptors in Mice Differentially Alters Small RNA Content of Circulating Extracellular Vesicles

Targeted Inhibition of Cardiomyocyte Gi Signaling Enhances Susceptibility to Apoptotic Cell Death in Response to Ischemic Stress

Darbepoetin alfa, a long-acting erythropoietin analog, offers novel and delayed cardioprotection for the ischemic heart

Characterization of βARKct engineered cellular extracellular vesicles and model specific cardioprotection

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