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An Efficient and Diastereoselective Synthesis of PSI-6130: A Clinically Efficacious Inhibitor of HCV NS5B Polymerase

Journal of organic chemistry, 2009-09, Vol.74 (17), p.6819-6824

2009

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Discovery of PSI-353661, a Novel Purine Nucleotide Prodrug for the Treatment of HCV Infection

ACS medicinal chemistry letters, 2011-02, Vol.2 (2), p.130-135

2011

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Use of 2′-Spirocyclic Ethers in HCV Nucleoside Design

Journal of medicinal chemistry, 2014-03, Vol.57 (5), p.1826-1835

2014

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Discovery of β-d-2′-deoxy-2′-α-fluoro-4′-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases

Bioorganic & medicinal chemistry letters, 2015-06, Vol.25 (12), p.2484-2487

2015

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Stereoselective Synthesis of PSI-352938: A β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyl-3′,5′-cyclic Phosphate Nucleotide Prodrug for the Treatment of HCV

Journal of organic chemistry, 2011-05, Vol.76 (10), p.3782-3790

2011

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2′-Deoxy-2′-α-fluoro-2′-β- C-methyl 3′,5′-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: Discovery of PSI-352938

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (24), p.7376-7380

2010

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β-d-2′-α-F-2′-β-C-Methyl-6-O-substituted 3′,5′-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: A structure–activity relationship study

Bioorganic & medicinal chemistry letters, 2012-09, Vol.22 (18), p.5924-5929

2012

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Synthesis and Biological Activity of 5′,9-Anhydro-3-Purine-ISONucleosides as Potential Anti-Hepatitis C Virus Agents

Nucleosides, nucleotides & nucleic acids, 2007-01, Vol.26 (1), p.83-97

2007

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Synthesis of Stable Isotope Labeled Analogs of the Anti-Hepatitis C Virus Nucleotide Prodrugs PSI-7977 and PSI-352938

Nucleosides, nucleotides & nucleic acids, 2011-11, Vol.30 (11), p.886-896

2011

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Ring-expanded analogues of natural oxetanocin

Tetrahedron, 2004-11, Vol.60 (45), p.10261-10268

2004

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Synthesis of 5′,9-anhydro-3-(β- d-ribofuranosyl)xanthine, and 3,5′-anhydro-xanthosine as potential anti-hepatitis C virus agents

Tetrahedron letters, 2005-04, Vol.46 (16), p.2825-2827

2005

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Synthesis of 5'-C-methyl-1', 3'-dioxolan-4'-yl nucleosides

Bioorganic & medicinal chemistry letters, 2004-03, Vol.14 (5), p.1243-1245

2004

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RING-EXPANDED ANALOGUES OF NATURAL OXETANOCIN: (+) AND (−) HYDROXYMETHYL ISODIDEOXYADENOSINE

Nucleosides, nucleotides & nucleic acids, 2005-01, Vol.24 (5-7), p.725-728

2005

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Total synthesis of hydroxymethyl isonucleosides as potential antiviral agents

ARKIVOC, 2003-04, Vol.2003 (1), p.9-21

2003

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Unusual Olefin Formation by PhSe-F trans-Elimination

Nucleosides, nucleotides & nucleic acids, 2005-01, Vol.24 (9), p.1289-1292

2005

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Stereoselective Synthesis of PSI-352938: A β-D-2'-Deoxy-2'-α-fluoro-2'-β-C-methyl-3'-cyclic Phosphate Nucleotide Prodrug for the Treatment of HCV

Journal of organic chemistry, 2011, Vol.76 (10), p.3782-3790

2011

Volltextzugriff (PDF)

[beta]-d-2'-[alpha]-F-2'-[beta]-C-Methyl-6-O-substituted 3',5'-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: A structure-activity relationship study

Bioorganic & medicinal chemistry letters, 2012-09, Vol.22 (18), p.5924-5929

2012

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Unusual Olefin Formation by PhSe-F trans-Elimination

ChemInform, 2006-02, Vol.37 (8), p.no-no

2006

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Synthesis and Biological Activity of 5′,9-Anhydro-3-purine-isonucleosides as Potential anti-Hepatitis C Virus Agents

ChemInform, 2007-05, Vol.38 (21), p.no-no

2007

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An Efficient and Diastereoselective Synthesis of PSI-6130: A Clinically Efficacious Inhibitor of HCV NSSB Polymerase

Journal of organic chemistry, 2009, Vol.74 (17), p.6819-6824

2009

Volltextzugriff (PDF)

2'-Deoxy-2'-a-fluoro-2'-b-C-methyl 3',5'-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: Discovery of PSI-352938

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (24), p.7376-7380

2010

Volltextzugriff (PDF)

Synthesis of 5′-C-Methyl-1′,3′-dioxolan-4′-yl Nucleosides

ChemInform, 2004-07, Vol.35 (27), p.no-no

2004

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Synthesis and Structure−Activity Relationships of Novel Anti-hepatitis C Agents: N 3,5‘-Cyclo-4-(β-d-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one Derivatives

Journal of medicinal chemistry, 2005-10, Vol.48 (20), p.6454-6460

2005

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Synthesis and Structure−Activity Relationships of Novel Anti-hepatitis C Agents: N3,5‘-Cyclo-4-(β-d-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one Derivatives

Journal of medicinal chemistry, 2005-10, Vol.48 (20), p.6454-6460

2005

Volltextzugriff (PDF)

Synthesis and Biological Activity of 5′,9-Anhydro - 3-Purine- ISO Nucleosides as Potential Anti-Hepatitis C Virus Agents

Nucleosides, nucleotides & nucleic acids, 2007-01, Vol.26 (1), p.83-97

2007

Volltextzugriff (PDF)

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An Efficient and Diastereoselective Synthesis of PSI-6130: A Clinically Efficacious Inhibitor of HCV NS5B Polymerase

Discovery of PSI-353661, a Novel Purine Nucleotide Prodrug for the Treatment of HCV Infection

Use of 2′-Spirocyclic Ethers in HCV Nucleoside Design

Discovery of β-d-2′-deoxy-2′-α-fluoro-4′-α-cyano-5-aza-7,9-dideaza adenosine as a potent nucleoside inhibitor of respiratory syncytial virus with excellent selectivity over mitochondrial RNA and DNA polymerases

Stereoselective Synthesis of PSI-352938: A β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyl-3′,5′-cyclic Phosphate Nucleotide Prodrug for the Treatment of HCV

2′-Deoxy-2′-α-fluoro-2′-β- C-methyl 3′,5′-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: Discovery of PSI-352938

β-d-2′-α-F-2′-β-C-Methyl-6-O-substituted 3′,5′-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: A structure–activity relationship study

Synthesis and Biological Activity of 5′,9-Anhydro-3-Purine-ISONucleosides as Potential Anti-Hepatitis C Virus Agents

Synthesis of Stable Isotope Labeled Analogs of the Anti-Hepatitis C Virus Nucleotide Prodrugs PSI-7977 and PSI-352938

Ring-expanded analogues of natural oxetanocin

Synthesis of 5′,9-anhydro-3-(β- d-ribofuranosyl)xanthine, and 3,5′-anhydro-xanthosine as potential anti-hepatitis C virus agents

Synthesis of 5'-C-methyl-1', 3'-dioxolan-4'-yl nucleosides

RING-EXPANDED ANALOGUES OF NATURAL OXETANOCIN: (+) AND (−) HYDROXYMETHYL ISODIDEOXYADENOSINE

Total synthesis of hydroxymethyl isonucleosides as potential antiviral agents

Unusual Olefin Formation by PhSe-F trans-Elimination

Stereoselective Synthesis of PSI-352938: A β-D-2'-Deoxy-2'-α-fluoro-2'-β-C-methyl-3'-cyclic Phosphate Nucleotide Prodrug for the Treatment of HCV

[beta]-d-2'-[alpha]-F-2'-[beta]-C-Methyl-6-O-substituted 3',5'-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: A structure-activity relationship study

Unusual Olefin Formation by PhSe-F trans-Elimination

Synthesis and Biological Activity of 5′,9-Anhydro-3-purine-isonucleosides as Potential anti-Hepatitis C Virus Agents

An Efficient and Diastereoselective Synthesis of PSI-6130: A Clinically Efficacious Inhibitor of HCV NSSB Polymerase

2'-Deoxy-2'-a-fluoro-2'-b-C-methyl 3',5'-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: Discovery of PSI-352938

Synthesis of 5′-C-Methyl-1′,3′-dioxolan-4′-yl Nucleosides

Synthesis and Structure−Activity Relationships of Novel Anti-hepatitis C Agents: N 3,5‘-Cyclo-4-(β-d-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one Derivatives

Synthesis and Structure−Activity Relationships of Novel Anti-hepatitis C Agents: N3,5‘-Cyclo-4-(β-d-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one Derivatives

Synthesis and Biological Activity of 5′,9-Anhydro - 3-Purine- ISO Nucleosides as Potential Anti-Hepatitis C Virus Agents

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