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Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

Proceedings of the National Academy of Sciences - PNAS, 2011-03, Vol.108 (11), p.4400-4405

2011

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Structure–Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439)

Journal of medicinal chemistry, 2017-04, Vol.60 (7), p.2654-2668

2017

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In Vivo Activity of Aryl Ozonides against Schistosoma Species

Antimicrobial Agents and Chemotherapy, 2012-02, Vol.56 (2), p.1090-1092

2012

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Mefloquine--an aminoalcohol with promising antischistosomal properties in mice

PLoS neglected tropical diseases, 2009-01, Vol.3 (1), p.e350-e350

2009

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Metabonomic Investigations in Mice Infected with Schistosoma mansoni: An Approach for Biomarker Identification

Proceedings of the National Academy of Sciences - PNAS, 2004-08, Vol.101 (34), p.12676-12681

2004

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In Vitro and In Vivo Activities of Synthetic Trioxolanes against Major Human Schistosome Species

Antimicrobial Agents and Chemotherapy, 2007-04, Vol.51 (4), p.1440-1445

2007

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Evaluation of the In Vivo Activity of Tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini

Antimicrobial Agents and Chemotherapy, 2007-03, Vol.51 (3), p.1096-1098

2007

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Elimination of Schistosoma mansoni in infected mice by slow release of artemisone

International journal for parasitology -- drugs and drug resistance, 2017-08, Vol.7 (2), p.241-247

2017

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Comparative Antimalarial Activities of Six Pairs of 1,2,4,5-Tetraoxanes (Peroxide Dimers) and 1,2,4,5,7,8-Hexaoxonanes (Peroxide Trimers)

Antimicrobial Agents and Chemotherapy, 2007-08, Vol.51 (8), p.3033-3035

2007

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Comparative Antimalarial Activities and ADME Profiles of Ozonides (1,2,4-trioxolanes) OZ277, OZ439, and Their 1,2-Dioxolane, 1,2,4-Trioxane, and 1,2,4,5-Tetraoxane Isosteres

Journal of medicinal chemistry, 2013-03, Vol.56 (6), p.2547-2555

2013

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Ultrastructural Alterations in Adult Schistosoma mansoni Caused by Artemether

Memórias do Instituto Oswaldo Cruz, 2002-07, Vol.97 (5), p.717-724

2002

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Identification of an antimalarial synthetic trioxolane drug development candidate

Nature, 2004-08, Vol.430 (7002), p.900-904

2004

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The Structure−Activity Relationship of the Antimalarial Ozonide Arterolane (OZ277)

Journal of medicinal chemistry, 2010-01, Vol.53 (1), p.481-491

2010

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In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models

Experimental parasitology, 2007-03, Vol.115 (3), p.296-300

2007

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The structure and antimalarial activity of dispiro-1,2,4,5-tetraoxanes derived from (+)-dihydrocarvone

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (22), p.6359-6361

2010

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Praziquantel analogs with activity against juvenile Schistosoma mansoni

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (8), p.2481-2484

2010

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Tegumental alterations in juvenile Schistosoma haematobium harboured in hamsters following artemether treatment

Parasitology international, 2001-09, Vol.50 (3), p.175-183

2001

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Spiro- and Dispiro-1,2-dioxolanes: Contribution of Iron(II)-Mediated One-Electron vs Two-Electron Reduction to the Activity of Antimalarial Peroxides

Journal of medicinal chemistry, 2007-11, Vol.50 (23), p.5840-5847

2007

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Spiro and Dispiro-1,2,4-trioxolanes as Antimalarial Peroxides: Charting a Workable Structure−Activity Relationship Using Simple Prototypes

Journal of medicinal chemistry, 2005-07, Vol.48 (15), p.4953-4961

2005

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Malaria-Infected Mice Are Cured by Oral Administration of New Artemisinin Derivatives

Journal of medicinal chemistry, 2008-02, Vol.51 (4), p.1035-1042

2008

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Histopathological changes in adult Schistosoma japonicum harbored in mice treated with a single dose of mefloquine

Parasitology research (1987), 2009-06, Vol.104 (6), p.1407-1416

2009

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Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes

Bioorganic & medicinal chemistry, 2006-09, Vol.14 (18), p.6368-6382

2006

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Weak base dispiro-1,2,4-trioxolanes: Potent antimalarial ozonides

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (5), p.1260-1265

2007

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Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine

Bioorganic & medicinal chemistry letters, 2006-11, Vol.16 (21), p.5542-5545

2006

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Recent investigations of artemether, a novel agent for the prevention of schistosomiasis japonica, mansoni and haematobia

Acta tropica, 2002-05, Vol.82 (2), p.175-181

2002

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Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

Structure–Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439)

In Vivo Activity of Aryl Ozonides against Schistosoma Species

Mefloquine--an aminoalcohol with promising antischistosomal properties in mice

Metabonomic Investigations in Mice Infected with Schistosoma mansoni: An Approach for Biomarker Identification

In Vitro and In Vivo Activities of Synthetic Trioxolanes against Major Human Schistosome Species

Evaluation of the In Vivo Activity of Tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini

Elimination of Schistosoma mansoni in infected mice by slow release of artemisone

Comparative Antimalarial Activities of Six Pairs of 1,2,4,5-Tetraoxanes (Peroxide Dimers) and 1,2,4,5,7,8-Hexaoxonanes (Peroxide Trimers)

Comparative Antimalarial Activities and ADME Profiles of Ozonides (1,2,4-trioxolanes) OZ277, OZ439, and Their 1,2-Dioxolane, 1,2,4-Trioxane, and 1,2,4,5-Tetraoxane Isosteres

Ultrastructural Alterations in Adult Schistosoma mansoni Caused by Artemether

Identification of an antimalarial synthetic trioxolane drug development candidate

The Structure−Activity Relationship of the Antimalarial Ozonide Arterolane (OZ277)

In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models

The structure and antimalarial activity of dispiro-1,2,4,5-tetraoxanes derived from (+)-dihydrocarvone

Praziquantel analogs with activity against juvenile Schistosoma mansoni

Tegumental alterations in juvenile Schistosoma haematobium harboured in hamsters following artemether treatment

Spiro- and Dispiro-1,2-dioxolanes: Contribution of Iron(II)-Mediated One-Electron vs Two-Electron Reduction to the Activity of Antimalarial Peroxides

Spiro and Dispiro-1,2,4-trioxolanes as Antimalarial Peroxides: Charting a Workable Structure−Activity Relationship Using Simple Prototypes

Malaria-Infected Mice Are Cured by Oral Administration of New Artemisinin Derivatives

Histopathological changes in adult Schistosoma japonicum harbored in mice treated with a single dose of mefloquine

Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes

Weak base dispiro-1,2,4-trioxolanes: Potent antimalarial ozonides

Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine

Recent investigations of artemether, a novel agent for the prevention of schistosomiasis japonica, mansoni and haematobia

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