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Pharmacological effects of berberine and its derivatives: a patent update

Expert opinion on therapeutic patents, 2016-02, Vol.26 (2), p.229-243

2016

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Repurposing of cyclophilin A inhibitors as broad-spectrum antiviral agents

Drug discovery today, 2022-07, Vol.27 (7), p.1895-1912

2022

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Topoisomerase inhibitors as anticancer agents: a patent update

Expert opinion on therapeutic patents, 2013-08, Vol.23 (8), p.1033-1056

2013

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3-Arylisoquinolines as novel topoisomerase I inhibitors

Bioorganic & medicinal chemistry, 2011-01, Vol.19 (2), p.724-734

2011

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Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase–Dependent Regulation of the Orphan Nuclear Receptor SHP

Diabetes (New York, N.Y.), 2008-02, Vol.57 (2), p.306-314

2008

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Scoparone exerts anti-tumor activity against DU145 prostate cancer cells via inhibition of STAT3 activity

PloS one, 2013-11, Vol.8 (11), p.e80391

2013

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Antiviral Activity of Isoquinolone Derivatives against Influenza Viruses and Their Cytotoxicity

Pharmaceuticals (Basel, Switzerland), 2021-07, Vol.14 (7), p.650

2021

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Berberine bioisostere Q8 compound stimulates osteoblast differentiation and function in vitro

Pharmacological research, 2017-05, Vol.119, p.463-475

2017

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Insights into the Structural Features Essential for JAK2 Inhibition and Selectivity

Current medicinal chemistry, 2016-04, Vol.23 (13), p.1331-1355

2016

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Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines

Bioorganic & medicinal chemistry, 2010-05, Vol.18 (9), p.3066-3077

2010

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Dihydroxylated 2,4,6-triphenyl pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study

European journal of medicinal chemistry, 2012-03, Vol.49, p.219-228

2012

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Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety

European journal of medicinal chemistry, 2012-06, Vol.52, p.123-136

2012

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cAMP‐dependent activation of protein kinase A as a therapeutic target of skin hyperpigmentation by diphenylmethylene hydrazinecarbothioamide

British journal of pharmacology, 2015-07, Vol.172 (13), p.3434-3445

2015

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Structure-based design and synthesis of sulfonylureas as novel NLRP3 inhibitors for Alzheimer’s disease

Bioorganic & medicinal chemistry letters, 2024-02, Vol.99, p.129622-129622, Article 129622

2024

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The discovery of 2,5-isomers of triazole-pyrrolopyrimidine as selective Janus kinase 2 (JAK2) inhibitors versus JAK1 and JAK3

Bioorganic & medicinal chemistry, 2016-11, Vol.24 (21), p.5036-5046

2016

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Structure-based Virtual Screening and Identification of a Novel Androgen Receptor Antagonist

The Journal of biological chemistry, 2012-08, Vol.287 (36), p.30769-30780

2012

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Retinoic acid receptor-related orphan receptor α-induced activation of adenosine monophosphate-activated protein kinase results in attenuation of hepatic steatosis

Hepatology (Baltimore, Md.), 2012-05, Vol.55 (5), p.1379-1388

2012

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A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis

The Journal of clinical investigation, 2019-04, Vol.130 (4), p.1684-1698

2019

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Crystal Structure of Human Myotubularin-Related Protein 1 Provides Insight into the Structural Basis of Substrate Specificity

PloS one, 2016-03, Vol.11 (3), p.e0152611-e0152611

2016

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SAR Based Design of Nicotinamides as a Novel Class of Androgen Receptor Antagonists for Prostate Cancer

Journal of medicinal chemistry, 2013-04, Vol.56 (8), p.3414-3418

2013

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Crystal structure of pim1 kinase in complex with a pyrido[4,3-d]pyrimidine derivative suggests a unique binding mode

PloS one, 2013-07, Vol.8 (7), p.e70358-e70358

2013

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Design, Synthesis, and Bioevaluation of Novel MyD88 Inhibitor c17 against Acute Lung Injury Derived from the Virtual Screen

Journal of medicinal chemistry, 2023-05, Vol.66 (10), p.6938-6958

2023

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Discovery of the Diphenyl 6‑Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the JNK2-NF-κB/MAPK Pathway

Journal of medicinal chemistry, 2023-09, Vol.66 (17), p.12304-12323

2023

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Design, synthesis and bioactivity evaluation of 4-hydroxycoumarin derivatives as potential anti-inflammatory agents against acute lung injury and colitis

European journal of medicinal chemistry, 2024-06, Vol.272, p.116487-116487, Article 116487

2024

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Discovery of novel osthole derivatives exerting anti-inflammatory effect on DSS-induced ulcerative colitis and LPS-induced acute lung injury in mice

European journal of medicinal chemistry, 2024-03, Vol.268, p.116252-116252, Article 116252

2024

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Pharmacological effects of berberine and its derivatives: a patent update

Repurposing of cyclophilin A inhibitors as broad-spectrum antiviral agents

Topoisomerase inhibitors as anticancer agents: a patent update

3-Arylisoquinolines as novel topoisomerase I inhibitors

Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase–Dependent Regulation of the Orphan Nuclear Receptor SHP

Scoparone exerts anti-tumor activity against DU145 prostate cancer cells via inhibition of STAT3 activity

Antiviral Activity of Isoquinolone Derivatives against Influenza Viruses and Their Cytotoxicity

Berberine bioisostere Q8 compound stimulates osteoblast differentiation and function in vitro

Insights into the Structural Features Essential for JAK2 Inhibition and Selectivity

Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines

Dihydroxylated 2,4,6-triphenyl pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study

Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety

cAMP‐dependent activation of protein kinase A as a therapeutic target of skin hyperpigmentation by diphenylmethylene hydrazinecarbothioamide

Structure-based design and synthesis of sulfonylureas as novel NLRP3 inhibitors for Alzheimer’s disease

The discovery of 2,5-isomers of triazole-pyrrolopyrimidine as selective Janus kinase 2 (JAK2) inhibitors versus JAK1 and JAK3

Structure-based Virtual Screening and Identification of a Novel Androgen Receptor Antagonist

Retinoic acid receptor-related orphan receptor α-induced activation of adenosine monophosphate-activated protein kinase results in attenuation of hepatic steatosis

A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis

Crystal Structure of Human Myotubularin-Related Protein 1 Provides Insight into the Structural Basis of Substrate Specificity

SAR Based Design of Nicotinamides as a Novel Class of Androgen Receptor Antagonists for Prostate Cancer

Crystal structure of pim1 kinase in complex with a pyrido[4,3-d]pyrimidine derivative suggests a unique binding mode

Design, Synthesis, and Bioevaluation of Novel MyD88 Inhibitor c17 against Acute Lung Injury Derived from the Virtual Screen

Discovery of the Diphenyl 6‑Oxo-1,6-dihydropyridazine-3-carboxylate/carboxamide Analogue J27 for the Treatment of Acute Lung Injury and Sepsis by Targeting JNK2 and Inhibiting the JNK2-NF-κB/MAPK Pathway

Design, synthesis and bioactivity evaluation of 4-hydroxycoumarin derivatives as potential anti-inflammatory agents against acute lung injury and colitis

Discovery of novel osthole derivatives exerting anti-inflammatory effect on DSS-induced ulcerative colitis and LPS-induced acute lung injury in mice

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