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Expanding and reprogramming the genetic code

Nature (London), 2017-10, Vol.550 (7674), p.53-60

Chin, Jason W.

2017

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Expanding and Reprogramming the Genetic Code of Cells and Animals

Annual review of biochemistry, 2014-01, Vol.83 (1), p.379-408

Chin, Jason W

2014

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Cellular Incorporation of Unnatural Amino Acids and Bioorthogonal Labeling of Proteins

Chemical reviews, 2014-05, Vol.114 (9), p.4764-4806

2014

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Bioorthogonal Reactions for Labeling Proteins

ACS chemical biology, 2014-01, Vol.9 (1), p.16-20

2014

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Mutually orthogonal pyrrolysyl-tRNA synthetase/tRNA pairs

Nature chemistry, 2018-08, Vol.10 (8), p.831-837

2018

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Engineered triply orthogonal pyrrolysyl-tRNA synthetase/tRNA pairs enable the genetic encoding of three distinct non-canonical amino acids

Nature chemistry, 2020-06, Vol.12 (6), p.535-544

2020

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Efficient Multisite Unnatural Amino Acid Incorporation in Mammalian Cells via Optimized Pyrrolysyl tRNA Synthetase/tRNA Expression and Engineered eRF1

Journal of the American Chemical Society, 2014-11, Vol.136 (44), p.15577-15583

2014

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Cryo-EM structure of MukBEF reveals DNA loop entrapment at chromosomal unloading sites

Molecular cell, 2021-12, Vol.81 (23), p.4891-4906.e8

2021

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Concerted, Rapid, Quantitative, and Site-Specific Dual Labeling of Proteins

Journal of the American Chemical Society, 2014-06, Vol.136 (22), p.7785-7788

2014

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Selective, rapid and optically switchable regulation of protein function in live mammalian cells

Nature chemistry, 2015-07, Vol.7 (7), p.554-561

2015

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Genetically programmed cell-based synthesis of non-natural peptide and depsipeptide macrocycles

Nature chemistry, 2023-01, Vol.15 (1), p.61-69

2023

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Genetic Encoding of Bicyclononynes and trans-Cyclooctenes for Site-Specific Protein Labeling in Vitro and in Live Mammalian Cells via Rapid Fluorogenic Diels–Alder Reactions

Journal of the American Chemical Society, 2012-06, Vol.134 (25), p.10317-10320

2012

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RBBP6 activates the pre-mRNA 3' end processing machinery in humans

Genes & development, 2022-02, Vol.36 (3-4), p.210-224

2022

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Photocontrol of Tyrosine Phosphorylation in Mammalian Cells via Genetic Encoding of Photocaged Tyrosine

Journal of the American Chemical Society, 2012-07, Vol.134 (29), p.11912-11915

2012

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Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms

Nature (London), 2020-03, Vol.579 (7800), p.603-608

2020

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Discovery and Genetic Code Expansion of a Polyethylene Terephthalate (PET) Hydrolase from the Human Saliva Metagenome for the Degradation and Bio‐Functionalization of PET

Angewandte Chemie International Edition, 2022-09, Vol.61 (37), p.e202203061-n/a

International ed. in English, 2022

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Controlling orthogonal ribosome subunit interactions enables evolution of new function

Nature (London), 2018-12, Vol.564 (7736), p.444-448

2018

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Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog

Nature chemical biology, 2015-07, Vol.11 (7), p.496-503

2015

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Biosynthesis and genetic encoding of phosphothreonine through parallel selection and deep sequencing

Nature methods, 2017-07, Vol.14 (7), p.729-736

2017

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Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly

PLoS pathogens, 2014-10, Vol.10 (10), p.e1004459

2014

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Expanding the genetic code of Drosophila melanogaster

Nature chemical biology, 2012-09, Vol.8 (9), p.748-750

2012

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Selective CRAF Inhibition Elicits Transactivation

Journal of the American Chemical Society, 2021-03, Vol.143 (12), p.4600-4606

2021

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Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains

Proceedings of the National Academy of Sciences - PNAS, 2011-02, Vol.108 (6), p.2228-2233

2011

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Programmed chromosome fission and fusion enable precise large-scale genome rearrangement and assembly

Science (American Association for the Advancement of Science), 2019-08, Vol.365 (6456), p.922-926

2019

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Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase

Nature chemical biology, 2010-08, Vol.6 (10), p.750-757

2010

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Expanding and reprogramming the genetic code

Expanding and Reprogramming the Genetic Code of Cells and Animals

Cellular Incorporation of Unnatural Amino Acids and Bioorthogonal Labeling of Proteins

Bioorthogonal Reactions for Labeling Proteins

Mutually orthogonal pyrrolysyl-tRNA synthetase/tRNA pairs

Engineered triply orthogonal pyrrolysyl-tRNA synthetase/tRNA pairs enable the genetic encoding of three distinct non-canonical amino acids

Efficient Multisite Unnatural Amino Acid Incorporation in Mammalian Cells via Optimized Pyrrolysyl tRNA Synthetase/tRNA Expression and Engineered eRF1

Cryo-EM structure of MukBEF reveals DNA loop entrapment at chromosomal unloading sites

Concerted, Rapid, Quantitative, and Site-Specific Dual Labeling of Proteins

Selective, rapid and optically switchable regulation of protein function in live mammalian cells

Genetically programmed cell-based synthesis of non-natural peptide and depsipeptide macrocycles

Genetic Encoding of Bicyclononynes and trans-Cyclooctenes for Site-Specific Protein Labeling in Vitro and in Live Mammalian Cells via Rapid Fluorogenic Diels–Alder Reactions

RBBP6 activates the pre-mRNA 3' end processing machinery in humans

Photocontrol of Tyrosine Phosphorylation in Mammalian Cells via Genetic Encoding of Photocaged Tyrosine

Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms

Discovery and Genetic Code Expansion of a Polyethylene Terephthalate (PET) Hydrolase from the Human Saliva Metagenome for the Degradation and Bio‐Functionalization of PET

Controlling orthogonal ribosome subunit interactions enables evolution of new function

Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog

Biosynthesis and genetic encoding of phosphothreonine through parallel selection and deep sequencing

Host cofactors and pharmacologic ligands share an essential interface in HIV-1 capsid that is lost upon disassembly

Expanding the genetic code of Drosophila melanogaster

Selective CRAF Inhibition Elicits Transactivation

Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains

Programmed chromosome fission and fusion enable precise large-scale genome rearrangement and assembly

Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase

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