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Glucagon-Like Peptide 1/Glucagon Receptor Dual Agonism Reverses Obesity in Mice

Diabetes (New York, N.Y.), 2009-10, Vol.58 (10), p.2258-2266

2009

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Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors

Science (American Association for the Advancement of Science), 1998-09, Vol.281 (5383), p.1640-1645

1998

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Identification, localization and receptor characterization of novel mammalian substance P-like peptides

Gene, 2002-08, Vol.296 (1-2), p.205-212

2002

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Modulation of basal and stress-induced amygdaloid substance P release by the potent and selective NK1 receptor antagonist L-822429

Journal of neurochemistry, 2008-09, Vol.106 (6), p.2476-2488

2008

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The Glucagon Receptor Is Involved in Mediating the Body Weight‐Lowering Effects of Oxyntomodulin

Obesity (Silver Spring, Md.), 2012-08, Vol.20 (8), p.1566-1571

2012

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Structural Optimization Affording 2-(R)-(1-(R)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist

Journal of medicinal chemistry, 1998-11, Vol.41 (23), p.4607-4614

1998

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Differential effects of oxyntomodulin and GLP-1 on glucose metabolism

American journal of physiology: endocrinology and metabolism, 2012-07, Vol.303 (2), p.E265-E271

2012

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An Orally Active, Water-Soluble Neurokinin-1 Receptor Antagonist Suitable for Both Intravenous and Oral Clinical Administration

Journal of medicinal chemistry, 2001-11, Vol.44 (24), p.4296-4299

2001

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Brain penetration of aprepitant, a substance P receptor antagonist, in ferrets

Drug metabolism and disposition, 2003-06, Vol.31 (6), p.785

2003

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Characterization of a Novel, Non-peptidyl Antagonist of the Human Glucagon Receptor

The Journal of biological chemistry, 1999-03, Vol.274 (13), p.8694-8697

1999

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Comparison of the functional blockade of rat substance P (NK 1) receptors by GR205171, RP67580, SR140333 and NKP-608

Neuropharmacology, 2003-08, Vol.45 (2), p.231-241

2003

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2-Aryl indole NK1 receptor antagonists : Optimisation of indole substitution

Bioorganic & medicinal chemistry letters, 2001-05, Vol.11 (9), p.1233-1236

2001

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A novel series of indazole-/indole-based glucagon receptor antagonists

Bioorganic & medicinal chemistry letters, 2015-10, Vol.25 (19), p.4143-4147

2015

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Synthesis and structure-activity relationships of 8-azabicyclo[3.2.1]octane benzylamine NK1 antagonists

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (4), p.811-814

2006

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Combinatorial synthesis of 3-(Amidoalkyl) and 3-(Aminoalkyl)-2-arylindole derivatives: discovery of potent ligands for a variety of G-protein coupled receptors

Bioorganic & medicinal chemistry letters, 2002-01, Vol.12 (1), p.93-96

2002

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Cyclopentane-based human NK1 antagonists. Part 2: Development of potent, orally active, water-soluble derivatives

Bioorganic & medicinal chemistry letters, 2006-09, Vol.16 (17), p.4504-4511

2006

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1-Phenyl-8-azabicyclo[3.2.1]octane ethers: A novel series of neurokinin (NK 1) antagonists

Bioorganic & medicinal chemistry letters, 2006-04, Vol.16 (7), p.2008-2012

2006

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The discovery of potent, selective, and orally bioavailable hNK1 antagonists derived from pyrrolidine

Bioorganic & medicinal chemistry letters, 2007-09, Vol.17 (18), p.5191-5198

2007

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Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs

Journal of medicinal chemistry, 2000-03, Vol.43 (6), p.1234-1241

2000

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2-Aryl indole NK1 receptor antagonists : Optimisation of the 2-aryl ring and the indole nitrogen substituent

Bioorganic & medicinal chemistry letters, 2001-05, Vol.11 (9), p.1237-1240

2001

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Chronic substance P (NK 1) receptor antagonist and conventional antidepressant treatment increases burst firing of monoamine neurones in the locus coeruleus

Neuroscience, 2002-01, Vol.109 (3), p.609-617

2002

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SAR exploration at the C-3 position of tetrahydro-β-carboline sstr3 antagonists

Bioorganic & medicinal chemistry letters, 2016-03, Vol.26 (6), p.1529-1535

2016

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NK1 antagonists based on seven membered lactam scaffolds

Bioorganic & medicinal chemistry letters, 2006-06, Vol.16 (11), p.2929-2932

2006

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Discovery of substituted (4-phenyl-1H-imidazol-2-yl)methanamine as potent somatostatin receptor 3 agonists

Bioorganic & medicinal chemistry letters, 2015-09, Vol.25 (17), p.3520-3525

2015

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Glucagon-Like Peptide 1/Glucagon Receptor Dual Agonism Reverses Obesity in Mice

Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors

Identification, localization and receptor characterization of novel mammalian substance P-like peptides

Modulation of basal and stress-induced amygdaloid substance P release by the potent and selective NK1 receptor antagonist L-822429

The Glucagon Receptor Is Involved in Mediating the Body Weight‐Lowering Effects of Oxyntomodulin

Structural Optimization Affording 2-(R)-(1-(R)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist

Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes

Differential effects of oxyntomodulin and GLP-1 on glucose metabolism

An Orally Active, Water-Soluble Neurokinin-1 Receptor Antagonist Suitable for Both Intravenous and Oral Clinical Administration

Brain penetration of aprepitant, a substance P receptor antagonist, in ferrets

Characterization of a Novel, Non-peptidyl Antagonist of the Human Glucagon Receptor

Comparison of the functional blockade of rat substance P (NK 1) receptors by GR205171, RP67580, SR140333 and NKP-608

2-Aryl indole NK1 receptor antagonists : Optimisation of indole substitution

A novel series of indazole-/indole-based glucagon receptor antagonists

Synthesis and structure-activity relationships of 8-azabicyclo[3.2.1]octane benzylamine NK1 antagonists

Combinatorial synthesis of 3-(Amidoalkyl) and 3-(Aminoalkyl)-2-arylindole derivatives: discovery of potent ligands for a variety of G-protein coupled receptors

Cyclopentane-based human NK1 antagonists. Part 2: Development of potent, orally active, water-soluble derivatives

1-Phenyl-8-azabicyclo[3.2.1]octane ethers: A novel series of neurokinin (NK 1) antagonists

The discovery of potent, selective, and orally bioavailable hNK1 antagonists derived from pyrrolidine

Phosphorylated Morpholine Acetal Human Neurokinin-1 Receptor Antagonists as Water-Soluble Prodrugs

2-Aryl indole NK1 receptor antagonists : Optimisation of the 2-aryl ring and the indole nitrogen substituent

Chronic substance P (NK 1) receptor antagonist and conventional antidepressant treatment increases burst firing of monoamine neurones in the locus coeruleus

SAR exploration at the C-3 position of tetrahydro-β-carboline sstr3 antagonists

NK1 antagonists based on seven membered lactam scaffolds

Discovery of substituted (4-phenyl-1H-imidazol-2-yl)methanamine as potent somatostatin receptor 3 agonists

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