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Discovery of fingolimod based on the chemical modification of a natural product from the fungus, Isaria sinclairii

Journal of antibiotics, 2020-10, Vol.73 (10), p.666-678

Chiba, Kenji

2020

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Diversity and plasticity of microglial cells in psychiatric and neurological disorders

Pharmacology & therapeutics (Oxford), 2015-10, Vol.154, p.21-35

2015

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FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors

Pharmacology & therapeutics (Oxford), 2005-12, Vol.108 (3), p.308-319

Chiba, Kenji

2005

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Role of microglial m1/m2 polarization in relapse and remission of psychiatric disorders and diseases

Pharmaceuticals, 2014-11, Vol.7 (12), p.1028-1048

2014

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Significant association between clinical characteristics and changes in peripheral immuno-phenotype in large vessel vasculitis

Arthritis research & therapy, 2019-12, Vol.21 (1), p.304-304, Article 304

2019

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Longitudinal immune cell monitoring identified CD14++ CD16+ intermediate monocyte as a marker of relapse in patients with ANCA-associated vasculitis

Arthritis research & therapy, 2020-06, Vol.22 (1), p.1-145, Article 145

2020

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Role of interferons (IFNs) in the differentiation of T peripheral helper (Tph) cells

International immunology, 2022-09, Vol.34 (10), p.533-544

2022

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Role of interferons (IFNs) in the differentiation of T peripheral helper (Tph) cells

International immunology, 2022-09, Vol.34 (10), p.519-532

2022

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Discovery of fingolimod, the sphingosine 1-phosphate receptor modulator and its application for the therapy of multiple sclerosis

Future medicinal chemistry, 2012-04, Vol.4 (6), p.771-781

2012

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Proton Pump Inhibitor and Tacrolimus Uses are Associated With Hypomagnesemia in Connective Tissue Disease: a Potential Link With Renal Dysfunction and Recurrent Infection

Frontiers in pharmacology, 2021-05, Vol.12, p.616719-616719

2021

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Sphingosine 1-phosphate receptor type 1 regulates egress of mature T cells from mouse bone marrow

International immunology, 2010-06, Vol.22 (6), p.515-525

2010

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S1P lyase in thymic perivascular spaces promotes egress of mature thymocytes via up-regulation of S1P receptor 1

International immunology, 2014-05, Vol.26 (5), p.245-255

2014

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Role of Sphingosine 1-Phosphate Receptor Type 1 in Lymphocyte Egress from Secondary Lymphoid Tissues and Thymus

Cellular & molecular immunology, 2006-02, Vol.3 (1), p.11-19

2006

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Involvement of Neuroinflammation during Brain Development in Social Cognitive Deficits in Autism Spectrum Disorder and Schizophrenia

The Journal of pharmacology and experimental therapeutics, 2016-09, Vol.358 (3), p.504

2016

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FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration

Cellular & molecular immunology, 2005-12, Vol.2 (6), p.439-448

2005

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Cytotoxic Tph subset with low B-cell helper functions and its involvement in systemic lupus erythematosus

Communications biology, 2024-03, Vol.7 (1), p.277-277, Article 277

2024

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Sphingosine 1-phosphate receptor 1 as a useful target for treatment of multiple sclerosis

Pharmaceuticals, 2012-05, Vol.5 (5), p.514-528

2012

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Fingolimod (FTY720) stimulates Ca(2+)/calcineurin signaling in fission yeast

PloS one, 2013, Vol.8 (12), p.e81907-e81907

2013

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FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. I. FTY720 Selectively Decreases the Number of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing

The Journal of immunology (1950), 1998-05, Vol.160 (10), p.5037-5044

1998

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FTY720 stimulated ROS generation and the Sty1/Atf1 signaling pathway in the fission yeast Schizosaccharomyces pombe

Genes to cells : devoted to molecular & cellular mechanisms, 2014-04, Vol.19 (4), p.325-337

2014

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Synthesis and Immunosuppressive Activity of 2-Substituted 2-Aminopropane-1,3-diols and 2-Aminoethanols

Journal of medicinal chemistry, 2000-07, Vol.43 (15), p.2946-2961

2000

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Sphingosine 1-phosphate receptor type 1 as a novel target for the therapy of autoimmune diseases

Inflammation and Regeneration, 2010, Vol.30(3), pp.160-168

Chiba, Kenji

2010

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C5a promotes migration, proliferation, and vessel formation in endothelial cells

Inflammation research, 2010-08, Vol.59 (8), p.659-666

2010

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Immunosuppressant FTY720 inhibits thymocyte emigration

European journal of immunology, 2000-05, Vol.30 (5), p.1435-1444

2000

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Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate

Bioorganic & medicinal chemistry, 2005-01, Vol.13 (2), p.425-432

2005

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Discovery of fingolimod based on the chemical modification of a natural product from the fungus, Isaria sinclairii

Diversity and plasticity of microglial cells in psychiatric and neurological disorders

FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate receptors

Role of microglial m1/m2 polarization in relapse and remission of psychiatric disorders and diseases

Significant association between clinical characteristics and changes in peripheral immuno-phenotype in large vessel vasculitis

Longitudinal immune cell monitoring identified CD14++ CD16+ intermediate monocyte as a marker of relapse in patients with ANCA-associated vasculitis

Role of interferons (IFNs) in the differentiation of T peripheral helper (Tph) cells

Role of interferons (IFNs) in the differentiation of T peripheral helper (Tph) cells

Discovery of fingolimod, the sphingosine 1-phosphate receptor modulator and its application for the therapy of multiple sclerosis

Proton Pump Inhibitor and Tacrolimus Uses are Associated With Hypomagnesemia in Connective Tissue Disease: a Potential Link With Renal Dysfunction and Recurrent Infection

Sphingosine 1-phosphate receptor type 1 regulates egress of mature T cells from mouse bone marrow

S1P lyase in thymic perivascular spaces promotes egress of mature thymocytes via up-regulation of S1P receptor 1

Role of Sphingosine 1-Phosphate Receptor Type 1 in Lymphocyte Egress from Secondary Lymphoid Tissues and Thymus

Involvement of Neuroinflammation during Brain Development in Social Cognitive Deficits in Autism Spectrum Disorder and Schizophrenia

FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration

Cytotoxic Tph subset with low B-cell helper functions and its involvement in systemic lupus erythematosus

Sphingosine 1-phosphate receptor 1 as a useful target for treatment of multiple sclerosis

Fingolimod (FTY720) stimulates Ca(2+)/calcineurin signaling in fission yeast

FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. I. FTY720 Selectively Decreases the Number of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing

FTY720 stimulated ROS generation and the Sty1/Atf1 signaling pathway in the fission yeast Schizosaccharomyces pombe

Synthesis and Immunosuppressive Activity of 2-Substituted 2-Aminopropane-1,3-diols and 2-Aminoethanols

Sphingosine 1-phosphate receptor type 1 as a novel target for the therapy of autoimmune diseases

C5a promotes migration, proliferation, and vessel formation in endothelial cells

Immunosuppressant FTY720 inhibits thymocyte emigration

Asymmetric synthesis and biological evaluation of the enantiomeric isomers of the immunosuppressive FTY720-phosphate

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