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Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium

Cell stem cell, 2020-12, Vol.27 (6), p.937-950.e9

2020

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Identification of SARS-CoV‑2 3CL Protease Inhibitors by a Quantitative High-Throughput Screening

ACS pharmacology & translational science, 2020-10, Vol.3 (5), p.1008-1016

2020

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Mining of high throughput screening database reveals AP-1 and autophagy pathways as potential targets for COVID-19 therapeutics

Scientific reports, 2021-03, Vol.11 (1), p.6725-6725, Article 6725

2021

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Host heparan sulfate promotes ACE2 super-cluster assembly and enhances SARS-CoV-2-associated syncytium formation

Nature communications, 2023-09, Vol.14 (1), p.5777-5777, Article 5777

2023

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Therapeutic Strategies For Tay-Sachs Disease

Frontiers in pharmacology, 2022-07, Vol.13, p.906647-906647

2022

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Identification of 53 compounds that block Ebola virus-like particle entry via a repurposing screen of approved drugs

Emerging microbes & infections, 2014-12, Vol.3 (12), p.e84-7

2014

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Preclinical Pharmacokinetics and In Vitro Properties of GS-441524, a Potential Oral Drug Candidate for COVID-19 Treatment

Frontiers in pharmacology, 2022-08, Vol.13

2022

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Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

Frontiers in pharmacology, 2021-01, Vol.11, p.592737-592737

2021

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Mitoxantrone modulates a heparan sulfate-spike complex to inhibit SARS-CoV-2 infection

Scientific reports, 2022-04, Vol.12 (1), p.6294-6294, Article 6294

2022

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Drug Discovery Strategies for SARS-CoV-2

The Journal of pharmacology and experimental therapeutics, 2020-10, Vol.375 (1), p.127

2020

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The SARS-CoV‑2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules

ACS infectious diseases, 2021-06, Vol.7 (6), p.1389-1408

2021

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Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules

Nature communications, 2013-06, Vol.4 (1), p.2044-2044, Article 2044

2013

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Investigation of Interactions at the Extracellular Loops of the Relaxin Family Peptide Receptor 1 (RXFP1)

The Journal of biological chemistry, 2014-12, Vol.289 (50), p.34938-34952

2014

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Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1

Nature communications, 2013, Vol.4 (1), p.1953-1953, Article 1953

2013

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Neural stem cells for disease modeling of Wolman disease and evaluation of therapeutics

Orphanet journal of rare diseases, 2017-06, Vol.12 (1), p.120-120, Article 120

2017

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Generation of an induced pluripotent stem cell line (TRNDi031-A) from a patient with Alagille syndrome type 1 carrying a heterozygous p. C312X (c. 936 T > A) mutation in JAGGED-1

Stem cell research, 2021-07, Vol.54, p.102447-102447, Article 102447

2021

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Elp1p, the Yeast Homolog of the FD Disease Syndrome Protein, Negatively Regulates Exocytosis Independently of Transcriptional Elongation

Molecular cell, 2005-03, Vol.17 (6), p.841-853

2005

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RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery

SLAS DISCOVERY: Advancing the Science of Drug Discovery, 2020-12, Vol.25 (10), p.1141-1151

2020

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Two high-throughput screening assays for aberrant RNA–protein interactions in myotonic dystrophy type 1

Analytical and bioanalytical chemistry, 2012-02, Vol.402 (5), p.1889-1898

2012

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A high throughput screening assay system for the identification of small molecule inhibitors of gsp

PloS one, 2014-03, Vol.9 (3), p.e90766-e90766

2014

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A high throughput screening assay for inhibitors of SARS-CoV-2 pseudotyped particle entry

SLAS discovery, 2022-03, Vol.27 (2), p.86-94

2022

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Efficient Identification of Anti-SARS-CoV‑2 Compounds Using Chemical Structure- and Biological Activity-Based Modeling

Journal of medicinal chemistry, 2022-03, Vol.65 (6), p.4590-4599

2022

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High-Throughput Giardia lamblia Viability Assay Using Bioluminescent ATP Content Measurements

Antimicrobial Agents and Chemotherapy, 2011-02, Vol.55 (2), p.667-675

2011

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Synergistic and Antagonistic Drug Combinations against SARS-CoV-2

Molecular therapy, 2021-02, Vol.29 (2), p.873-885

2021

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Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium

Identification of SARS-CoV‑2 3CL Protease Inhibitors by a Quantitative High-Throughput Screening

Mining of high throughput screening database reveals AP-1 and autophagy pathways as potential targets for COVID-19 therapeutics

Host heparan sulfate promotes ACE2 super-cluster assembly and enhances SARS-CoV-2-associated syncytium formation

Therapeutic Strategies For Tay-Sachs Disease

Identification of 53 compounds that block Ebola virus-like particle entry via a repurposing screen of approved drugs

Preclinical Pharmacokinetics and In Vitro Properties of GS-441524, a Potential Oral Drug Candidate for COVID-19 Treatment

Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2

Mitoxantrone modulates a heparan sulfate-spike complex to inhibit SARS-CoV-2 infection

A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike

Drug Discovery Strategies for SARS-CoV-2

The SARS-CoV‑2 Cytopathic Effect Is Blocked by Lysosome Alkalizing Small Molecules

Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules

Investigation of Interactions at the Extracellular Loops of the Relaxin Family Peptide Receptor 1 (RXFP1)

Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1

Neural stem cells for disease modeling of Wolman disease and evaluation of therapeutics

Generation of an induced pluripotent stem cell line (TRNDi031-A) from a patient with Alagille syndrome type 1 carrying a heterozygous p. C312X (c. 936 T > A) mutation in JAGGED-1

Elp1p, the Yeast Homolog of the FD Disease Syndrome Protein, Negatively Regulates Exocytosis Independently of Transcriptional Elongation

RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery

Two high-throughput screening assays for aberrant RNA–protein interactions in myotonic dystrophy type 1

A high throughput screening assay system for the identification of small molecule inhibitors of gsp

A high throughput screening assay for inhibitors of SARS-CoV-2 pseudotyped particle entry

Efficient Identification of Anti-SARS-CoV‑2 Compounds Using Chemical Structure- and Biological Activity-Based Modeling

High-Throughput Giardia lamblia Viability Assay Using Bioluminescent ATP Content Measurements

Synergistic and Antagonistic Drug Combinations against SARS-CoV-2

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