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BLU-5937: A selective P2X3 antagonist with potent anti-tussive effect and no taste alteration

Pulmonary pharmacology & therapeutics, 2019-06, Vol.56, p.56-62

2019

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The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (3), p.923-928

2008

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Discovery of a Potent and Selective Prostaglandin D2 Receptor Antagonist, [(3R)-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic Acid (MK-0524)

Journal of medicinal chemistry, 2007-02, Vol.50 (4), p.794-806

2007

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A generally applicable method for assessing the electrophilicity and reactivity of diverse nitrile-containing compounds

Bioorganic & medicinal chemistry letters, 2007-02, Vol.17 (4), p.998-1002

2007

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In vitro comparison of cytochrome P450-mediated metabolic activities in human, dog, cat, and horse

Drug metabolism and disposition, 1997-10, Vol.25 (10), p.1130

1997

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Discovery of a potent and selective agonist of the prostaglandin EP4 receptor

Bioorganic & medicinal chemistry letters, 2003-03, Vol.13 (6), p.1129-1132

2003

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Substituted coumarins as potent 5-lipoxygenase inhibitors

Bioorganic & medicinal chemistry letters, 2006-05, Vol.16 (9), p.2528-2531

2006

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Description of a 96-Well Plate Assay to Measure Cytochrome P4503A Inhibition in Human Liver Microsomes Using a Selective Fluorescent Probe

Analytical biochemistry, 1999-12, Vol.276 (2), p.215-226

1999

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Hypoxia‐induced down‐regulation of CYP1A1/1A2 and up‐regulation of CYP3A6 involves serum mediators

British journal of pharmacology, 2002-11, Vol.137 (6), p.881-891

2002

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Improving metabolic stability of phosphodiesterase-4 inhibitors containing a substituted catechol: prevention of reactive intermediate formation and covalent binding

Bioorganic & medicinal chemistry letters, 2002-08, Vol.12 (16), p.2149-2152

2002

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Selective isolation of in vitro phase II conjugates using a lipophilic anionic exchange solid phase extraction method

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008-03, Vol.863 (2), p.242-248

2008

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Interspecies in vitro metabolism of the phosphodiesterase-4 (PDE4) inhibitor L-454,560

Journal of mass spectrometry., 2006-06, Vol.41 (6), p.771-780

2006

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Structure-activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP3 antagonists

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (3), p.527-530

2005

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The use of 3-[2-(N,N-diethyl-N-methylammonium)ethyl]-7-methoxy-4-methylcoumarin (AMMC) as a specific CYP2D6 probe in human liver microsomes

Drug metabolism and disposition, 2001-09, Vol.29 (9), p.1196

2001

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Erratum to “Evaluation of human hepatocyte incubation as a new tool for metabolism study of androstenedione and norandrostenedione in a doping control perspective”: [J. Chromatogr. B. 780 (2002) 145–153]

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2003-04, Vol.787 (2), p.427-427

2003

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USE OF A BENZYLOXY-SUBSTITUTED LACTONE CYCLOOXYGENASE-2 INHIBITOR AS A SELECTIVE FLUORESCENT PROBE FOR CYP3A ACTIVITY IN PRIMARY CULTURED RAT AND HUMAN HEPATOCYTES

Drug metabolism and disposition, 2004-12, Vol.32 (12), p.1509-1515

2004

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In Vitro and In Vivo Mechanistic Studies toward Understanding the Role of 1-Aminobenzotriazole in Rat Drug-Drug Interactions

Drug metabolism and disposition, 2015-12, Vol.43 (12), p.1960-1965

2015

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Evaluation of VCH-759 monotherapy in hepatitis C infection

Journal of hepatology, 2009-07, Vol.51 (1), p.39-46

2009

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Discovery of a Potent and Selective Prostaglandin D 2 Receptor Antagonist, [(3 R )-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[ b ]indol-3-yl]-acetic Acid (MK-0524)

Journal of medicinal chemistry, 2007-02, Vol.50 (4), p.794-806

2007

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Pharmacokinetics and metabolism in rats, dogs, and monkeys of the cathepsin k inhibitor odanacatib: demethylation of a methylsulfonyl moiety as a major metabolic pathway

Drug metabolism and disposition, 2011-06, Vol.39 (6), p.1079-1087

2011

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Investigation of the in vitro metabolism profile of a phosphodiesterase-IV inhibitor, CDP-840: leading to structural optimization

Drug metabolism and disposition, 2001-03, Vol.29 (3), p.232

2001

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Discovery of Novel Thiophene-Based, Thumb Pocket 2 Allosteric Inhibitors of the Hepatitis C NS5B Polymerase with Improved Potency and Physicochemical Profiles

Journal of medicinal chemistry, 2016-07, Vol.59 (13), p.6293-6302

2016

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Effect of common organic solvents on in vitro cytochrome P450-mediated metabolic activities in human liver microsomes

Drug metabolism and disposition, 1998-01, Vol.26 (1), p.1

1998

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Dioxabicyclooctanyl Naphthalenenitriles as Nonredox 5-Lipoxygenase Inhibitors: Structure−Activity Relationship Study Directed toward the Improvement of Metabolic Stability

Journal of medicinal chemistry, 1996-09, Vol.39 (20), p.3951-3970

1996

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In vitro metabolism of the COX-2 inhibitor DFU, including a novel glutathione adduct rearomatization

Drug metabolism and disposition, 2001-05, Vol.29 (5), p.638

2001

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BLU-5937: A selective P2X3 antagonist with potent anti-tussive effect and no taste alteration

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K

Discovery of a Potent and Selective Prostaglandin D2 Receptor Antagonist, [(3R)-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic Acid (MK-0524)

A generally applicable method for assessing the electrophilicity and reactivity of diverse nitrile-containing compounds

In vitro comparison of cytochrome P450-mediated metabolic activities in human, dog, cat, and horse

Discovery of a potent and selective agonist of the prostaglandin EP4 receptor

Substituted coumarins as potent 5-lipoxygenase inhibitors

Description of a 96-Well Plate Assay to Measure Cytochrome P4503A Inhibition in Human Liver Microsomes Using a Selective Fluorescent Probe

Hypoxia‐induced down‐regulation of CYP1A1/1A2 and up‐regulation of CYP3A6 involves serum mediators

Improving metabolic stability of phosphodiesterase-4 inhibitors containing a substituted catechol: prevention of reactive intermediate formation and covalent binding

Selective isolation of in vitro phase II conjugates using a lipophilic anionic exchange solid phase extraction method

Interspecies in vitro metabolism of the phosphodiesterase-4 (PDE4) inhibitor L-454,560

Structure-activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP3 antagonists

The use of 3-[2-(N,N-diethyl-N-methylammonium)ethyl]-7-methoxy-4-methylcoumarin (AMMC) as a specific CYP2D6 probe in human liver microsomes

Erratum to “Evaluation of human hepatocyte incubation as a new tool for metabolism study of androstenedione and norandrostenedione in a doping control perspective”: [J. Chromatogr. B. 780 (2002) 145–153]

USE OF A BENZYLOXY-SUBSTITUTED LACTONE CYCLOOXYGENASE-2 INHIBITOR AS A SELECTIVE FLUORESCENT PROBE FOR CYP3A ACTIVITY IN PRIMARY CULTURED RAT AND HUMAN HEPATOCYTES

In Vitro and In Vivo Mechanistic Studies toward Understanding the Role of 1-Aminobenzotriazole in Rat Drug-Drug Interactions

Evaluation of VCH-759 monotherapy in hepatitis C infection

Discovery of a Potent and Selective Prostaglandin D 2 Receptor Antagonist, [(3 R )-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[ b ]indol-3-yl]-acetic Acid (MK-0524)

Pharmacokinetics and metabolism in rats, dogs, and monkeys of the cathepsin k inhibitor odanacatib: demethylation of a methylsulfonyl moiety as a major metabolic pathway

Investigation of the in vitro metabolism profile of a phosphodiesterase-IV inhibitor, CDP-840: leading to structural optimization

Discovery of Novel Thiophene-Based, Thumb Pocket 2 Allosteric Inhibitors of the Hepatitis C NS5B Polymerase with Improved Potency and Physicochemical Profiles

Effect of common organic solvents on in vitro cytochrome P450-mediated metabolic activities in human liver microsomes

Dioxabicyclooctanyl Naphthalenenitriles as Nonredox 5-Lipoxygenase Inhibitors: Structure−Activity Relationship Study Directed toward the Improvement of Metabolic Stability

In vitro metabolism of the COX-2 inhibitor DFU, including a novel glutathione adduct rearomatization

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