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Discovery of New Allosteric Modulators of the Urotensinergic System through Substitution of the Urotensin II-Related Peptide (URP) Phenylalanine Residue

Journal of medicinal chemistry, 2018-10, Vol.61 (19), p.8707-8716

2018

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Targeting the PAC1 Receptor for Neurological and Metabolic Disorders

Current topics in medicinal chemistry, 2019-01, Vol.19 (16), p.1399

2019

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Secondary conformational conversion is involved in glycosaminoglycans-mediated cellular uptake of the cationic cell-penetrating peptide PACAP

FEBS letters, 2014-12, Vol.588 (24), p.4590-4596

2014

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Characterizations of a synthetic pituitary adenylate cyclase-activating polypeptide analog displaying potent neuroprotective activity and reduced in vivo cardiovascular side effects in a Parkinson's disease model

Neuropharmacology, 2016-09, Vol.108, p.440-450

2016

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Peptide modification results in the formation of a dimer with a 60-fold enhanced antimicrobial activity

PloS one, 2017-03, Vol.12 (3), p.e0173783-e0173783

2017

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Perturbing dimer interactions and allosteric communication modulates the immunosuppressive activity of human galectin-7

The Journal of biological chemistry, 2021-11, Vol.297 (5), p.101308-101308, Article 101308

2021

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Effect of the pituitary adenylate cyclase-activating polypeptide on the autophagic activation observed in in vitro and in vivo models of Parkinson's disease

Biochimica et biophysica acta, 2016-04, Vol.1862 (4), p.688-695

2016

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A New Approach to Inhibit Prototypic Galectins

Trends in Glycoscience and Glycotechnology, 2018/05/25, Vol.30(172), pp.SE155-SE165

2018

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Antibacterial properties of the pituitary adenylate cyclase-activating polypeptide: A new human antimicrobial peptide

PloS one, 2018-11, Vol.13 (11), p.e0207366-e0207366

2018

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Intracellular Angiotensin-II Interacts With Nuclear Angiotensin Receptors in Cardiac Fibroblasts and Regulates RNA Synthesis, Cell Proliferation, and Collagen Secretion

Journal of the American Heart Association, 2017-04, Vol.6 (4)

2017

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Urotensin II, from fish to human

Annals of the New York Academy of Sciences, 2010-07, Vol.1200 (1), p.53-66

2010

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Placental Galectins in Cancer: Why We Should Pay More Attention

Cells (Basel, Switzerland), 2023-01, Vol.12 (3), p.437

2023

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Caged ligands to study the role of intracellular GPCRs

Methods (San Diego, Calif.), 2016-01, Vol.92, p.72-77

2016

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Development and Pharmacological Characterization of Conformationally Constrained Urotensin II-Related Peptide Agonists

Journal of medicinal chemistry, 2013-12, Vol.56 (23), p.9612-9622

2013

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The vasoactive peptides urotensin II and urotensin II-related peptide regulate astrocyte activity through common and distinct mechanisms: involvement in cell proliferation

Biochemical journal, 2010-04, Vol.428 (1), p.113-124

2010

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Insights into the Molecular Determinants Involved in Urocontrin and Urocontrin A Action

ACS medicinal chemistry letters, 2020-09, Vol.11 (9), p.1717-1722

2020

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Distribution of 26RFa binding sites and GPR103 mRNA in the central nervous system of the rat

Journal of comparative neurology (1911), 2007-08, Vol.503 (4), p.573-591

2007

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Towards Targeting the Urotensinergic System: Overview and Challenges

Trends in pharmacological sciences (Regular ed.), 2019-10, Vol.40 (10), p.725-734

2019

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Anatomical distribution and biochemical characterization of the novel RFamide peptide 26RFa in the human hypothalamus and spinal cord

Journal of neurochemistry, 2006-10, Vol.99 (2), p.616-627

2006

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Localization of the urotensin II receptor in the rat central nervous system

Journal of comparative neurology (1911), 2006-03, Vol.495 (1), p.21-36

2006

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Structure–activity relationships and structural conformation of a novel urotensin II-related peptide

Peptides (New York, N.Y. : 1980), 2004-10, Vol.25 (10), p.1819-1830

2004

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Characterization of urotensin II, distribution of urotensin II, urotensin II-related peptide and UT receptor mRNAs in mouse: evidence of urotensin II at the neuromuscular junction

Journal of neurochemistry, 2008-10, Vol.107 (2), p.361-374

2008

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Exploration of the urocontrin A scaffold yields new urotensinergic system allosteric modulator and competitive antagonists

Biochemical pharmacology, 2023-05, Vol.211, p.115485-115485, Article 115485

2023

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Structure–activity relationships of urotensin II and URP

Peptides (New York, N.Y. : 1980), 2008-05, Vol.29 (5), p.658-673

2008

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Behavioral effects of urotensin-II centrally administered in mice

Psychopharmacologia, 2005-11, Vol.183 (1), p.103-117

2005

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Discovery of New Allosteric Modulators of the Urotensinergic System through Substitution of the Urotensin II-Related Peptide (URP) Phenylalanine Residue

Targeting the PAC1 Receptor for Neurological and Metabolic Disorders

Secondary conformational conversion is involved in glycosaminoglycans-mediated cellular uptake of the cationic cell-penetrating peptide PACAP

Characterizations of a synthetic pituitary adenylate cyclase-activating polypeptide analog displaying potent neuroprotective activity and reduced in vivo cardiovascular side effects in a Parkinson's disease model

Peptide modification results in the formation of a dimer with a 60-fold enhanced antimicrobial activity

Perturbing dimer interactions and allosteric communication modulates the immunosuppressive activity of human galectin-7

Effect of the pituitary adenylate cyclase-activating polypeptide on the autophagic activation observed in in vitro and in vivo models of Parkinson's disease

A New Approach to Inhibit Prototypic Galectins

Antibacterial properties of the pituitary adenylate cyclase-activating polypeptide: A new human antimicrobial peptide

Intracellular Angiotensin-II Interacts With Nuclear Angiotensin Receptors in Cardiac Fibroblasts and Regulates RNA Synthesis, Cell Proliferation, and Collagen Secretion

Urotensin II, from fish to human

Placental Galectins in Cancer: Why We Should Pay More Attention

Caged ligands to study the role of intracellular GPCRs

Development and Pharmacological Characterization of Conformationally Constrained Urotensin II-Related Peptide Agonists

The vasoactive peptides urotensin II and urotensin II-related peptide regulate astrocyte activity through common and distinct mechanisms: involvement in cell proliferation

Insights into the Molecular Determinants Involved in Urocontrin and Urocontrin A Action

Distribution of 26RFa binding sites and GPR103 mRNA in the central nervous system of the rat

Towards Targeting the Urotensinergic System: Overview and Challenges

Anatomical distribution and biochemical characterization of the novel RFamide peptide 26RFa in the human hypothalamus and spinal cord

Localization of the urotensin II receptor in the rat central nervous system

Structure–activity relationships and structural conformation of a novel urotensin II-related peptide

Characterization of urotensin II, distribution of urotensin II, urotensin II-related peptide and UT receptor mRNAs in mouse: evidence of urotensin II at the neuromuscular junction

Exploration of the urocontrin A scaffold yields new urotensinergic system allosteric modulator and competitive antagonists

Structure–activity relationships of urotensin II and URP

Behavioral effects of urotensin-II centrally administered in mice

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