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Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

Proceedings of the National Academy of Sciences - PNAS, 2013-07, Vol.110 (29), p.E2724-E2732

2013

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The Effect on the Fetus of Medications Used to Treat Pregnant Inflammatory Bowel-Disease Patients

The American journal of gastroenterology, 2004-04, Vol.99 (4), p.656-661

2004

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The Selective Nav1.7 Inhibitor, PF-05089771, Interacts Equivalently with Fast and Slow Inactivated Nav1.7 Channels

Molecular pharmacology, 2016-11, Vol.90 (5), p.540-548

2016

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Recent progress in sodium channel modulators for pain

Bioorganic & medicinal chemistry letters, 2014-08, Vol.24 (16), p.3690-3699

2014

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A novel selective and orally bioavailable Nav1.8 channel blocker, PF‐01247324, attenuates nociception and sensory neuron excitability

British journal of pharmacology, 2015-05, Vol.172 (10), p.2654-2670

2015

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Discovery of Clinical Candidate 4‑[2-(5-Amino‑1H‑pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro‑N‑1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7

Journal of medicinal chemistry, 2017-08, Vol.60 (16), p.7029-7042

2017

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Discovery of the First Orally Available, Selective KNa1.1 Inhibitor: In Vitro and In Vivo Activity of an Oxadiazole Series

ACS medicinal chemistry letters, 2021-04, Vol.12 (4), p.593-602

2021

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Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain

Bioorganic & medicinal chemistry, 2008-06, Vol.16 (12), p.6379-6386

2008

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Discovery of the First Orally Available, Selective K Na 1.1 Inhibitor: In Vitro and In Vivo Activity of an Oxadiazole Series

ACS medicinal chemistry letters, 2021-04, Vol.12 (4), p.593-602

2021

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GYGD pore motifs in neighbouring potassium channel subunits interact to determine ion selectivity

The Journal of physiology, 2001-01, Vol.530 (1), p.21-33

2001

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A-887826 is a structurally novel, potent and voltage-dependent Na(v)1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats

Neuropharmacology, 2010-09, Vol.59 (3), p.201-207

2010

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Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na V 1.7

Journal of medicinal chemistry, 2017-08, Vol.60 (16), p.7029-7042

2017

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K channel subconductance levels result from heteromeric pore conformations

The Journal of general physiology, 2005-08, Vol.126 (2), p.87-103

2005

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The influence of crank configuration on muscle activity and torque production during arm crank ergometry

Journal of electromyography and kinesiology, 2008-08, Vol.18 (4), p.598-605

2008

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Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain

Bioorganic & medicinal chemistry, 2010-11, Vol.18 (22), p.7816-7825

2010

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Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Nav1.8 sodium channel with efficacy in a model of neuropathic pain

Bioorganic & medicinal chemistry, 2010-11, Vol.18 (22), p.7816-7825

2010

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Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (22), p.6812-6815

2010

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Subtype-selective Nav1.8 sodium channel blockers: Identification of potent, orally active nicotinamide derivatives

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (22), p.6812-6815

2010

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The Effect of κ-Opioid Receptor Agonists on Tetrodotoxin-Resistant Sodium Channels in Primary Sensory Neurons

Anesthesia and analgesia, 2009-08, Vol.109 (2), p.632-640

2009

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Erratum to “The influence of crank configuration on muscle activity and torque production during arm crank ergometry” [J. Electromyogr. Kines. 18 (2008) 598–605]

Journal of electromyography and kinesiology, 2009-06, Vol.19 (3), p.542-542

2009

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1047 Chromoendoscopy Is Superior to Standard Surveillance Techniques for Both High and Low Risk Patients for the Detection of Dysplasia: Analysis of a Prospective Controlled Trial

Gastroenterology (New York, N.Y. 1943), 2009, Vol.136 (5), p.A-160-A-160

2009

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The Selective Na v 1.7 Inhibitor, PF-05089771, Interacts Equivalently with Fast and Slow Inactivated Na v 1.7 Channels

Molecular pharmacology, 2016-11, Vol.90 (5), p.540-548

2016

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Allosteric effects of external K+ ions mediated by the aspartate of the GYGD signature sequence in the Kv2.1 K+ channel

Pflügers Archiv, 2006-03, Vol.451 (6), p.776-792

2006

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Identification of Novel Pore Interactions for Selective Nav1.8 Inhibitors

Biophysical journal, 2016-02, Vol.110 (3), p.112a-113a

2016

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Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

The Effect on the Fetus of Medications Used to Treat Pregnant Inflammatory Bowel-Disease Patients

The Selective Nav1.7 Inhibitor, PF-05089771, Interacts Equivalently with Fast and Slow Inactivated Nav1.7 Channels

Recent progress in sodium channel modulators for pain

A novel selective and orally bioavailable Nav1.8 channel blocker, PF‐01247324, attenuates nociception and sensory neuron excitability

Discovery of Clinical Candidate 4‑[2-(5-Amino‑1H‑pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro‑N‑1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7

Discovery of the First Orally Available, Selective KNa1.1 Inhibitor: In Vitro and In Vivo Activity of an Oxadiazole Series

Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain

Discovery of the First Orally Available, Selective K Na 1.1 Inhibitor: In Vitro and In Vivo Activity of an Oxadiazole Series

GYGD pore motifs in neighbouring potassium channel subunits interact to determine ion selectivity

A-887826 is a structurally novel, potent and voltage-dependent Na(v)1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats

Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na V 1.7

K channel subconductance levels result from heteromeric pore conformations

The influence of crank configuration on muscle activity and torque production during arm crank ergometry

Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Na(v)1.8 sodium channel with efficacy in a model of neuropathic pain

Discovery and biological evaluation of potent, selective, orally bioavailable, pyrazine-based blockers of the Nav1.8 sodium channel with efficacy in a model of neuropathic pain

Subtype-selective Na(v)1.8 sodium channel blockers: identification of potent, orally active nicotinamide derivatives

Subtype-selective Nav1.8 sodium channel blockers: Identification of potent, orally active nicotinamide derivatives

The Effect of κ-Opioid Receptor Agonists on Tetrodotoxin-Resistant Sodium Channels in Primary Sensory Neurons

Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

Erratum to “The influence of crank configuration on muscle activity and torque production during arm crank ergometry” [J. Electromyogr. Kines. 18 (2008) 598–605]

1047 Chromoendoscopy Is Superior to Standard Surveillance Techniques for Both High and Low Risk Patients for the Detection of Dysplasia: Analysis of a Prospective Controlled Trial

The Selective Na v 1.7 Inhibitor, PF-05089771, Interacts Equivalently with Fast and Slow Inactivated Na v 1.7 Channels

Allosteric effects of external K+ ions mediated by the aspartate of the GYGD signature sequence in the Kv2.1 K+ channel

Identification of Novel Pore Interactions for Selective Nav1.8 Inhibitors

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