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Structure−Activity Relationship Studies of Salinosporamide A (NPI-0052), a Novel Marine Derived Proteasome Inhibitor

Journal of medicinal chemistry, 2005-06, Vol.48 (11), p.3684-3687

2005

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NPI-0052 Enhances Tumoricidal Response to Conventional Cancer Therapy in a Colon Cancer Model

Clinical cancer research, 2006-11, Vol.12 (22), p.6758-6764

2006

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Leaving Groups Prolong the Duration of 20S Proteasome Inhibition and Enhance the Potency of Salinosporamides

Journal of medicinal chemistry, 2008-11, Vol.51 (21), p.6711-6724

2008

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MEKK3 Directly Regulates MEK5 Activity as Part of the Big Mitogen-activated Protein Kinase 1 (BMK1) Signaling Pathway

The Journal of biological chemistry, 1999-12, Vol.274 (51), p.36035-36038

1999

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A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

Cancer cell, 2005-11, Vol.8 (5), p.407-419

2005

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Selective Activation of Liver X Receptors by Acanthoic Acid-Related Diterpenes

Molecular pharmacology, 2007-06, Vol.71 (6), p.1545-1553

2007

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An Autologous Oral DNA Vaccine Protects against Murine Melanoma

Proceedings of the National Academy of Sciences - PNAS, 2000-05, Vol.97 (10), p.5492-5497

2000

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BMK1 Mediates Growth Factor-induced Cell Proliferation through Direct Cellular Activation of Serum and Glucocorticoid-inducible Kinase

The Journal of biological chemistry, 2001-03, Vol.276 (12), p.8631-8634

2001

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Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-κB–regulated gene products

Blood, 2007-10, Vol.110 (7), p.2286-2295

2007

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Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs

The Journal of pharmacology and experimental therapeutics, 2011-05, Vol.337 (2), p.479-486

2011

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Identification of MAVS splicing variants that interfere with RIGI/MAVS pathway signaling

Molecular immunology, 2008-04, Vol.45 (8), p.2277-2287

2008

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Salinosporamides D−J from the Marine Actinomycete Salinispora tropica, Bromosalinosporamide, and Thioester Derivatives Are Potent Inhibitors of the 20S Proteasome

Journal of natural products (Washington, D.C.), 2007-02, Vol.70 (2), p.269-276

2007

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Role of the Second Extracellular Loop of Human C3a Receptor in Agonist Binding and Receptor Function

The Journal of biological chemistry, 1999-04, Vol.274 (14), p.9721-9728

1999

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New Family of Synthetic Diterpenes that Regulates Cytokine Synthesis by Inhibiting IκBα Phosphorylation

Chembiochem : a European journal of chemical biology, 2005-01, Vol.6 (1), p.133-144

2005

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Tid1, the human homologue of a Drosophila tumor suppressor, reduces the malignant activity of ErbB-2 in carcinoma cells

Cancer research (Chicago, Ill.), 2004-11, Vol.64 (21), p.7732-7739

2004

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Identification of ligand effector binding sites in transmembrane regions of the human G protein-coupled C3a receptor

Protein science, 1999-11, Vol.8 (11), p.2304-2311

1999

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Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents

Bioorganic & medicinal chemistry letters, 2003-10, Vol.13 (19), p.3217-3221

2003

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Investigating the cellular BMK1/ERK5 signaling pathway

Methods in molecular biology (Clifton, N.J.), 2004, Vol.250, p.89

2004

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Cloning, nucleotide sequence and characterization of a full-length cDNA encoding the myosin heavy chain from adult chicken pectoralis major muscle

Gene, 1997-10, Vol.199 (1), p.265-270

1997

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Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products

Blood, 2007-10, Vol.110 (7), p.2286

2007

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Synthesis of a Novel Family of Diterpenes and Their Evaluation as Antiinflammatory Agents

ChemInform, 2003-12, Vol.34 (51), p.no-no

2003

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Targeting Therapy for Resistant Multiple Myeloma with a Novel Inhibitor of NF-KB, NPI-1387

Blood, 2005-11, Vol.106 (11), p.640-640

2005

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In Vitro and In Vivo Proteasome Activity Profiles of Bortezomib and a Novel Proteasome Inhibitor NPI-0052

Blood, 2005-11, Vol.106 (11), p.3363-3363

2005

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Role of BMK1 in regulation of growth factor-induced cellular responses

Immunologic research, 2000-01, Vol.21 (2-3), p.233-237

2000

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A new family of synthetic diterpenes that regulates cytokine synthesis by inhibiting IkappaBalpha phosphorylation

Chembiochem : a European journal of chemical biology, 2005-01, Vol.6 (1), p.133-144

2005

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Structure−Activity Relationship Studies of Salinosporamide A (NPI-0052), a Novel Marine Derived Proteasome Inhibitor

NPI-0052 Enhances Tumoricidal Response to Conventional Cancer Therapy in a Colon Cancer Model

Leaving Groups Prolong the Duration of 20S Proteasome Inhibition and Enhance the Potency of Salinosporamides

MEKK3 Directly Regulates MEK5 Activity as Part of the Big Mitogen-activated Protein Kinase 1 (BMK1) Signaling Pathway

A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

Selective Activation of Liver X Receptors by Acanthoic Acid-Related Diterpenes

An Autologous Oral DNA Vaccine Protects against Murine Melanoma

BMK1 Mediates Growth Factor-induced Cell Proliferation through Direct Cellular Activation of Serum and Glucocorticoid-inducible Kinase

Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-κB–regulated gene products

Proteasome regulator marizomib (NPI-0052) exhibits prolonged inhibition, attenuated efflux, and greater cytotoxicity than its reversible analogs

Identification of MAVS splicing variants that interfere with RIGI/MAVS pathway signaling

Salinosporamides D−J from the Marine Actinomycete Salinispora tropica, Bromosalinosporamide, and Thioester Derivatives Are Potent Inhibitors of the 20S Proteasome

Role of the Second Extracellular Loop of Human C3a Receptor in Agonist Binding and Receptor Function

New Family of Synthetic Diterpenes that Regulates Cytokine Synthesis by Inhibiting IκBα Phosphorylation

Tid1, the human homologue of a Drosophila tumor suppressor, reduces the malignant activity of ErbB-2 in carcinoma cells

Identification of ligand effector binding sites in transmembrane regions of the human G protein-coupled C3a receptor

Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents

Investigating the cellular BMK1/ERK5 signaling pathway

Cloning, nucleotide sequence and characterization of a full-length cDNA encoding the myosin heavy chain from adult chicken pectoralis major muscle

Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products

Synthesis of a Novel Family of Diterpenes and Their Evaluation as Antiinflammatory Agents

Targeting Therapy for Resistant Multiple Myeloma with a Novel Inhibitor of NF-KB, NPI-1387

In Vitro and In Vivo Proteasome Activity Profiles of Bortezomib and a Novel Proteasome Inhibitor NPI-0052

Role of BMK1 in regulation of growth factor-induced cellular responses

A new family of synthetic diterpenes that regulates cytokine synthesis by inhibiting IkappaBalpha phosphorylation

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