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3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice

Science translational medicine, 2020-08, Vol.12 (557)

2020

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Inhibition of influenza virus replication by plant-derived isoquercetin

Antiviral research, 2010-11, Vol.88 (2), p.227-235

2010

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Broad-Spectrum Antivirals against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses, and Coronaviruses

Journal of Virology, 2012-11, Vol.86 (21), p.11754-11762

2012

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Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor

PLoS pathogens, 2016-03, Vol.12 (3), p.e1005531-e1005531

2016

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Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis

Journal of feline medicine and surgery, 2018-04, Vol.20 (4), p.378-392

2018

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Role of Cholesterol Pathways in Norovirus Replication

Journal of Virology, 2009-09, Vol.83 (17), p.8587-8595

CHANG, Kyeong-Ok

2009

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Intestinal colonization with Escherichia fergusonii enhances infectivity of GII.12 human norovirus in gnotobiotic pigs

Virus research, 2023-10, Vol.336, p.199219-199219, Article 199219

2023

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Structure-Guided Design of Conformationally Constrained Cyclohexane Inhibitors of Severe Acute Respiratory Syndrome Coronavirus‑2 3CL Protease

Journal of medicinal chemistry, 2021-07, Vol.64 (14), p.10047-10058

2021

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The crucial role of bile acids in the entry of porcine enteric calicivirus

Virology (New York, N.Y.), 2014-05, Vol.456, p.268-278

2014

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Roles of host proteases in the entry of SARS-CoV-2

Animal diseases, 2023-04, Vol.3 (1), p.12-12, Article 12

2023

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Antiviral Drug Discovery: Norovirus Proteases and Development of Inhibitors

Viruses, 2019-02, Vol.11 (2), p.197

2019

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Endosomal acidification and cathepsin L activity is required for calicivirus replication

Virology (New York, N.Y.), 2014-09, Vol.464, p.287-295

2014

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Structure-Guided Design of Potent Spirocyclic Inhibitors of Severe Acute Respiratory Syndrome Coronavirus‑2 3C-like Protease

Journal of medicinal chemistry, 2022-06, Vol.65 (11), p.7818-7832

2022

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Putative structural rearrangements associated with the interaction of macrocyclic inhibitors with norovirus 3CL protease

Proteins, structure, function, and bioinformatics, 2019-07, Vol.87 (7), p.579-587

2019

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Interferons and Ribavirin Effectively Inhibit Norwalk Virus Replication in Replicon-Bearing Cells

Journal of Virology, 2007-11, Vol.81 (22), p.12111-12118

2007

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IRF-1, RIG-I and MDA5 display potent antiviral activities against norovirus coordinately induced by different types of interferons

Antiviral research, 2018-07, Vol.155, p.48-59

2018

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Broad-spectrum inhibitors against 3C-like proteases of feline coronaviruses and feline caliciviruses

Journal of virology, 2015-05, Vol.89 (9), p.4942-4950

2015

Volltextzugriff (PDF)

Recent Advances in the Discovery of Norovirus Therapeutics

Journal of medicinal chemistry, 2015-12, Vol.58 (24), p.9438-9450

2015

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Potent 3CLpro inhibitors effective against SARS-CoV-2 and MERS-CoV in animal models by therapeutic treatment

mBio, 2024-02, Vol.15 (2), p.e0287823-e0287823

2024

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Replication of Norovirus in cell culture reveals a tropism for dendritic cells and macrophages

PLoS biology, 2004-12, Vol.2 (12), p.e432-e432

2004

Volltextzugriff (PDF)

The effects of simvastatin or interferon-α on infectivity of human norovirus using a gnotobiotic pig model for the study of antivirals

PloS one, 2012-07, Vol.7 (7), p.e41619

2012

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Antiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein response

PLoS pathogens, 2012-07, Vol.8 (7), p.e1002783

2012

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Effects of Spike Mutations in SARS-CoV-2 Variants of Concern on Human or Animal ACE2-Mediated Virus Entry and Neutralization

Microbiology spectrum, 2022-06, Vol.10 (3), p.e0178921-e0178921

2022

Volltextzugriff (PDF)

Potent Protease Inhibitors of Highly Pathogenic Lagoviruses: Rabbit Hemorrhagic Disease Virus and European Brown Hare Syndrome Virus

Microbiology spectrum, 2022-08, Vol.10 (4), p.e0014222-e0014222

2022

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Potent small molecule inhibitors against the 3C protease of foot-and-mouth disease virus

Microbiology spectrum, 2024-04, Vol.12 (4), p.e0337223-e0337223

2024

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3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice

Inhibition of influenza virus replication by plant-derived isoquercetin

Broad-Spectrum Antivirals against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses, and Coronaviruses

Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor

Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis

Role of Cholesterol Pathways in Norovirus Replication

Intestinal colonization with Escherichia fergusonii enhances infectivity of GII.12 human norovirus in gnotobiotic pigs

Structure-Guided Design of Conformationally Constrained Cyclohexane Inhibitors of Severe Acute Respiratory Syndrome Coronavirus‑2 3CL Protease

The crucial role of bile acids in the entry of porcine enteric calicivirus

Roles of host proteases in the entry of SARS-CoV-2

Antiviral Drug Discovery: Norovirus Proteases and Development of Inhibitors

Endosomal acidification and cathepsin L activity is required for calicivirus replication

Structure-Guided Design of Potent Spirocyclic Inhibitors of Severe Acute Respiratory Syndrome Coronavirus‑2 3C-like Protease

Putative structural rearrangements associated with the interaction of macrocyclic inhibitors with norovirus 3CL protease

Interferons and Ribavirin Effectively Inhibit Norwalk Virus Replication in Replicon-Bearing Cells

IRF-1, RIG-I and MDA5 display potent antiviral activities against norovirus coordinately induced by different types of interferons

Broad-spectrum inhibitors against 3C-like proteases of feline coronaviruses and feline caliciviruses

Recent Advances in the Discovery of Norovirus Therapeutics

Potent 3CLpro inhibitors effective against SARS-CoV-2 and MERS-CoV in animal models by therapeutic treatment

Replication of Norovirus in cell culture reveals a tropism for dendritic cells and macrophages

The effects of simvastatin or interferon-α on infectivity of human norovirus using a gnotobiotic pig model for the study of antivirals

Antiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein response

Effects of Spike Mutations in SARS-CoV-2 Variants of Concern on Human or Animal ACE2-Mediated Virus Entry and Neutralization

Potent Protease Inhibitors of Highly Pathogenic Lagoviruses: Rabbit Hemorrhagic Disease Virus and European Brown Hare Syndrome Virus

Potent small molecule inhibitors against the 3C protease of foot-and-mouth disease virus

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