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A Novel Naphthyridine Derivative, 3u, Induces Necroptosis at Low Concentrations and Apoptosis at High Concentrations in Human Melanoma A375 Cells

International journal of molecular sciences, 2018-09, Vol.19 (10), p.2975

2018

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Overcoming resistance to TRAIL-induced apoptosis in solid tumor cells by simultaneously targeting death receptors, c-FLIP and IAPs

International journal of oncology, 2016-07, Vol.49 (1), p.153-163

2016

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Metal-free oxidative arylphosphination of activated N-substituted-N-arylacrylamide derivatives using K2S2O8

Tetrahedron, 2014-03, Vol.70 (11), p.1991-1996

2014

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An atom-economic green approach: oxidative synthesis of functionalized 1,4-dihydropyridines from N,N-dimethylenaminones and amines

Tetrahedron letters, 2015-02, Vol.56 (6), p.837-841

2015

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Copper-catalyzed cascade addition/cyclization: highly efficient access to phosphonylated quinoline-2,4(1H,3H)-diones

Organic & biomolecular chemistry, 2015-05, Vol.13 (19), p.5376-5380

2015

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Arylnitration of alkenes by nitration/C–H functionalization cascade using AgNO3 and HOAc

Tetrahedron letters, 2014-03, Vol.55 (13), p.2119-2122

2014

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Homology modeling and 3D–QSAR study of benzhydrylpiperazine δ opioid receptor agonists

Computational biology and chemistry, 2019-12, Vol.83, p.107109-107109, Article 107109

2019

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A practical nickel-catalyzed reductive alkylation of amidophenyl bromides

Tetrahedron, 2014-12, Vol.70 (50), p.9522-9529

2014

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Synthesis of (1R,4R)-2,5-diazabicyclo[2.2.1]heptane derivatives by an epimerization-lactamization cascade reaction

RSC advances, 2015-01, Vol.5 (14), p.1386-1392

2015

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The opioid receptor triple agonist DPI-125 produces analgesia with less respiratory depression and reduced abuse liability

Acta pharmacologica Sinica, 2017-07, Vol.38 (7), p.977-989

2017

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Synthesis of 5,6-Dihydro-α-Pyrone via Ring-Closing Metathesis and Intramolecular Horner–Wadsworth–Emmons Reactions

Journal of chemical research, 2015-01, Vol.39 (1), p.1-3

2015

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DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. I. A mixed opioid agonist with potent antinociceptive activity

The Journal of pharmacology and experimental therapeutics, 2003-12, Vol.307 (3), p.1221-1226

2003

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Inhibition of c-FLIP by RNAi Enhances Sensitivity of the Human Osteogenic Sarcoma Cell Line U2OS to TRAILInduced Apoptosis

Asian Pacific journal of cancer prevention : APJCP, 2015-04, Vol.16 (6), p.2251-2256

2015

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DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. II. A mixed opioid agonist with potent antinociceptive activity and limited effects on respiratory function

The Journal of pharmacology and experimental therapeutics, 2003-12, Vol.307 (3), p.1227-1233

2003

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ARD-353 [4-((2R,5S)-4-(R)-(4-diethylcarbamoylphenyl)(3-hydroxyphenyl)methyl)-2,5-dimethylpiperazin-1-ylmethyl)benzoic acid], a novel nonpeptide delta receptor agonist, reduces myocardial infarct size without central effects

The Journal of pharmacology and experimental therapeutics, 2006-01, Vol.316 (1), p.423-430

2006

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DPI-221 [4-((alpha-s)-alpha-((2s,5r)-2,5-dimethyl-4-(3-fluorobenzyl)-1-piperazinyl)benzyl)-N,N-diethylbenzamide]: a novel nonpeptide delta receptor agonist producing increased micturition interval in normal rats

The Journal of pharmacology and experimental therapeutics, 2005-11, Vol.315 (2), p.601-608

2005

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Immunohistochemical localization of enkephalin in rat brain and spinal cord

Journal of comparative neurology (1911), 1978-11, Vol.182 (1), p.17-37

1978

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A novel, potent and selective nonpeptidic delta opioid receptor agonist BW373U86

The Journal of pharmacology and experimental therapeutics, 1993-11, Vol.267 (2), p.852

1993

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Localization of enkephalin-like immunoreactivity to identified axonal and neuronal populations of the rat hippocampus

Journal of comparative neurology (1911), 1981-05, Vol.198 (2), p.335-350

1981

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Specific Nonopiate Receptors for β-Endorphin

Science (American Association for the Advancement of Science), 1979-09, Vol.205 (4410), p.1033-1035

1979

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Morphiceptin (NH4-tyr-pro-phe-pro-COHN2): a potent and specific agonist for morphine (mu) receptors

Science (American Association for the Advancement of Science), 1981-04, Vol.212 (4490), p.75-77

1981

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Inhibition of c-FLIP by RNAi Enhances Sensitivity of the Human Osteogenic Sarcoma Cell Line U2OS to TRAILInduced Apoptosis

Asian Pacific journal of cancer prevention : APJCP, 2015, Vol.16 (6), p.2251-2256

2015

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Quantitative autoradiographic analysis of Mu and delta opioid binding sites in the rat hippocampal formation

Journal of comparative neurology (1911), 1986-04, Vol.246 (2), p.170-180

1986

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BW373U86, a δ-opioid receptor agonist, reverses bradykinin-induced thermal allodynia in rhesus monkeys

European journal of pharmacology, 1995-04, Vol.277 (2), p.285-287

1995

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Inhibition of ras-induced germinal vesicle breakdown in Xenopus oocytes by rap-1B

Biochemical and biophysical research communications, 1991-01, Vol.174 (1), p.1-5

1991

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A Novel Naphthyridine Derivative, 3u, Induces Necroptosis at Low Concentrations and Apoptosis at High Concentrations in Human Melanoma A375 Cells

Overcoming resistance to TRAIL-induced apoptosis in solid tumor cells by simultaneously targeting death receptors, c-FLIP and IAPs

Metal-free oxidative arylphosphination of activated N-substituted-N-arylacrylamide derivatives using K2S2O8

An atom-economic green approach: oxidative synthesis of functionalized 1,4-dihydropyridines from N,N-dimethylenaminones and amines

Copper-catalyzed cascade addition/cyclization: highly efficient access to phosphonylated quinoline-2,4(1H,3H)-diones

Arylnitration of alkenes by nitration/C–H functionalization cascade using AgNO3 and HOAc

Homology modeling and 3D–QSAR study of benzhydrylpiperazine δ opioid receptor agonists

A practical nickel-catalyzed reductive alkylation of amidophenyl bromides

Synthesis of (1R,4R)-2,5-diazabicyclo[2.2.1]heptane derivatives by an epimerization-lactamization cascade reaction

The opioid receptor triple agonist DPI-125 produces analgesia with less respiratory depression and reduced abuse liability

Synthesis of 5,6-Dihydro-α-Pyrone via Ring-Closing Metathesis and Intramolecular Horner–Wadsworth–Emmons Reactions

DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. I. A mixed opioid agonist with potent antinociceptive activity

Inhibition of c-FLIP by RNAi Enhances Sensitivity of the Human Osteogenic Sarcoma Cell Line U2OS to TRAILInduced Apoptosis

DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. II. A mixed opioid agonist with potent antinociceptive activity and limited effects on respiratory function

ARD-353 [4-((2R,5S)-4-(R)-(4-diethylcarbamoylphenyl)(3-hydroxyphenyl)methyl)-2,5-dimethylpiperazin-1-ylmethyl)benzoic acid], a novel nonpeptide delta receptor agonist, reduces myocardial infarct size without central effects

DPI-221 [4-((alpha-s)-alpha-((2s,5r)-2,5-dimethyl-4-(3-fluorobenzyl)-1-piperazinyl)benzyl)-N,N-diethylbenzamide]: a novel nonpeptide delta receptor agonist producing increased micturition interval in normal rats

Immunohistochemical localization of enkephalin in rat brain and spinal cord

A novel, potent and selective nonpeptidic delta opioid receptor agonist BW373U86

Localization of enkephalin-like immunoreactivity to identified axonal and neuronal populations of the rat hippocampus

Specific Nonopiate Receptors for β-Endorphin

Morphiceptin (NH4-tyr-pro-phe-pro-COHN2): a potent and specific agonist for morphine (mu) receptors

Inhibition of c-FLIP by RNAi Enhances Sensitivity of the Human Osteogenic Sarcoma Cell Line U2OS to TRAILInduced Apoptosis

Quantitative autoradiographic analysis of Mu and delta opioid binding sites in the rat hippocampal formation

BW373U86, a δ-opioid receptor agonist, reverses bradykinin-induced thermal allodynia in rhesus monkeys

Inhibition of ras-induced germinal vesicle breakdown in Xenopus oocytes by rap-1B

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