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Crystal Structures of the RNA-dependent RNA Polymerase Genotype 2a of Hepatitis C Virus Reveal Two Conformations and Suggest Mechanisms of Inhibition by Non-nucleoside Inhibitors

The Journal of biological chemistry, 2005-05, Vol.280 (18), p.18202-18210

2005

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Synthesis and evaluation of NS5A inhibitors containing diverse heteroaromatic cores

Bioorganic & medicinal chemistry letters, 2015-02, Vol.25 (4), p.948-951

2015

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Benzimidazole-containing HCV NS5A inhibitors: Effect of 4-substituted pyrrolidines in balancing genotype 1a and 1b potency

Bioorganic & medicinal chemistry letters, 2015-02, Vol.25 (4), p.944-947

2015

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Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 2: Non-symmetric inhibitors with potent activity against genotype 1a and 1b

Bioorganic & medicinal chemistry letters, 2015-02, Vol.25 (4), p.940-943

2015

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Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 1: C2-Symmetric inhibitors with diyne and biphenyl linkers

Bioorganic & medicinal chemistry letters, 2015-02, Vol.25 (4), p.936-939

2015

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Antiviral Properties of a Series of 1,6-Naphthyridine and 7,8-Dihydroisoquinoline Derivatives Exhibiting Potent Activity against Human Cytomegalovirus

Antimicrobial Agents and Chemotherapy, 2000-04, Vol.44 (4), p.929-937

2000

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Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition

The Journal of biological chemistry, 2003-03, Vol.278 (11), p.9489-9495

2003

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Les enjeux actuels des débats sur la mémoire et la réparation pour l’esclavage à l’île Maurice

Cahiers d'études africaines, 2004, Vol.44 (173/174), p.401-418

CHAN LOW, Laval Jocelyn

2004

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Discovery of Novel Thiophene-Based, Thumb Pocket 2 Allosteric Inhibitors of the Hepatitis C NS5B Polymerase with Improved Potency and Physicochemical Profiles

Journal of medicinal chemistry, 2016-07, Vol.59 (13), p.6293-6302

2016

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Comparative Study of the Anti-Human Cytomegalovirus Activities and Toxicities of a Tetrahydrofuran Phosphonate Analogue of Guanosine and Cidofovir

Antimicrobial Agents and Chemotherapy, 1999-03, Vol.43 (3), p.557-567

1999

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Non-nucleoside Analogue Inhibitors Bind to an Allosteric Site on HCV NS5B Polymerase

The Journal of biological chemistry, 2003-03, Vol.278 (11), p.9489-9495

2003

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Docking Ligands into Flexible and Solvated Macromolecules. 2. Development and Application of Fitted 1.5 to the Virtual Screening of Potential HCV Polymerase Inhibitors

Journal of chemical information and computer sciences, 2008-04, Vol.48 (4), p.902-909

2008

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Non-nucleoside Inhibitors Binding to Hepatitis C Virus NS5B Polymerase Reveal a Novel Mechanism of Inhibition

Journal of molecular biology, 2006-08, Vol.361 (1), p.33-45

2006

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Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 1: C sub(2)-Symmetric inhibitors with diyne and biphenyl linkers

Bioorganic & medicinal chemistry letters, 2015-02, Vol.25 (4), p.936-939

2015

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Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: Tertiary amides

Bioorganic & medicinal chemistry letters, 2004-02, Vol.14 (3), p.797-800

2004

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Discovery of Thienoimidazole-Based HCV NS5A Genotype 1a and 1b Inhibitors

ACS medicinal chemistry letters, 2014-03, Vol.5 (3), p.240-243

2014

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Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides

Bioorganic & medicinal chemistry letters, 2004-02, Vol.14 (3), p.793-796

2004

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A novel RGD antagonist that targets both αvβ3 and α5β1 induces apoptosis of angiogenic endothelial cells on type I collagen

Vascular pharmacology, 2003, Vol.40 (2), p.77-89

2003

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Identification of N,N-Disubstituted Phenylalanines as a Novel Class of Inhibitors of Hepatitis C NS5B Polymerase

Journal of medicinal chemistry, 2003-04, Vol.46 (8), p.1283-1285

2003

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Docking Ligands into Flexible and Solvated Macromolecules. 2. Development and Application of F itted 1.5 to the Virtual Screening of Potential HCV Polymerase Inhibitors

Journal of chemical information and modeling, 2008-04, Vol.48 (4), p.902-909

2008

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Design and synthesis of a potent macrocyclic 1,6-napthyridine anti-human cytomegalovirus (HCMV) inhibitors

Bioorganic & medicinal chemistry letters, 2005-03, Vol.15 (6), p.1693-1695

2005

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Novel nucleotide phosphonate analogues with potent antitumor activity

Bioorganic & medicinal chemistry letters, 2002-11, Vol.12 (21), p.3063-3066

2002

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A stereoselective route to bioactive nucleotide phosphonate analogs

Tetrahedron letters, 2003-11, Vol.44 (45), p.8261-8263

2003

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Design and synthesis of a potent macrocyclic 1,6-naphthyridine anti-human cytomegalovirus (HCMV) inhibitors

Bioorganic & medicinal chemistry letters, 2005-03, Vol.15 (6), p.1693-1695

2005

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Thiophene-based vitronectin receptor antagonists

Bioorganic & medicinal chemistry letters, 2003-02, Vol.13 (3), p.503-506

2003

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Crystal Structures of the RNA-dependent RNA Polymerase Genotype 2a of Hepatitis C Virus Reveal Two Conformations and Suggest Mechanisms of Inhibition by Non-nucleoside Inhibitors

Synthesis and evaluation of NS5A inhibitors containing diverse heteroaromatic cores

Benzimidazole-containing HCV NS5A inhibitors: Effect of 4-substituted pyrrolidines in balancing genotype 1a and 1b potency

Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 2: Non-symmetric inhibitors with potent activity against genotype 1a and 1b

Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 1: C2-Symmetric inhibitors with diyne and biphenyl linkers

Antiviral Properties of a Series of 1,6-Naphthyridine and 7,8-Dihydroisoquinoline Derivatives Exhibiting Potent Activity against Human Cytomegalovirus

Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition

Les enjeux actuels des débats sur la mémoire et la réparation pour l’esclavage à l’île Maurice

Discovery of Novel Thiophene-Based, Thumb Pocket 2 Allosteric Inhibitors of the Hepatitis C NS5B Polymerase with Improved Potency and Physicochemical Profiles

Comparative Study of the Anti-Human Cytomegalovirus Activities and Toxicities of a Tetrahydrofuran Phosphonate Analogue of Guanosine and Cidofovir

Non-nucleoside Analogue Inhibitors Bind to an Allosteric Site on HCV NS5B Polymerase

Docking Ligands into Flexible and Solvated Macromolecules. 2. Development and Application of Fitted 1.5 to the Virtual Screening of Potential HCV Polymerase Inhibitors

Non-nucleoside Inhibitors Binding to Hepatitis C Virus NS5B Polymerase Reveal a Novel Mechanism of Inhibition

Discovery of thienoimidazole-based HCV NS5A inhibitors. Part 1: C sub(2)-Symmetric inhibitors with diyne and biphenyl linkers

Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: Tertiary amides

Discovery of Thienoimidazole-Based HCV NS5A Genotype 1a and 1b Inhibitors

Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides

A novel RGD antagonist that targets both αvβ3 and α5β1 induces apoptosis of angiogenic endothelial cells on type I collagen

Identification of N,N-Disubstituted Phenylalanines as a Novel Class of Inhibitors of Hepatitis C NS5B Polymerase

Docking Ligands into Flexible and Solvated Macromolecules. 2. Development and Application of F itted 1.5 to the Virtual Screening of Potential HCV Polymerase Inhibitors

Design and synthesis of a potent macrocyclic 1,6-napthyridine anti-human cytomegalovirus (HCMV) inhibitors

Novel nucleotide phosphonate analogues with potent antitumor activity

A stereoselective route to bioactive nucleotide phosphonate analogs

Design and synthesis of a potent macrocyclic 1,6-naphthyridine anti-human cytomegalovirus (HCMV) inhibitors

Thiophene-based vitronectin receptor antagonists

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