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Cancer Therapeutic Targeting of Hypoxia Induced Carbonic Anhydrase IX: From Bench to Bedside

Cancers, 2022-07, Vol.14 (14), p.3297

2022

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Carbonic anhydrase IX promotes myeloid-derived suppressor cell mobilization and establishment of a metastatic niche by stimulating G-CSF production

Cancer research (Chicago, Ill.), 2015-03, Vol.75 (6), p.996-1008

2015

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Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors

Cell stem cell, 2020-07, Vol.27 (1), p.110-124.e9

2020

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Targeting Hypoxia-Induced Carbonic Anhydrase IX Enhances Immune-Checkpoint Blockade Locally and Systemically

Cancer immunology research, 2019-07, Vol.7 (7), p.1064-1078

2019

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Overcoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune Dysfunction

Frontiers in cell and developmental biology, 2016-03, Vol.4, p.27-27

2016

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Dual Antigen T Cell Engagers Targeting CA9 as an Effective Immunotherapeutic Modality for Targeting CA9 in Solid Tumors

Frontiers in immunology, 2022-07, Vol.13, p.905768-905768

2022

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Scyl1 facilitates nuclear tRNA export in mammalian cells by acting at the nuclear pore complex

Molecular biology of the cell, 2010-07, Vol.21 (14), p.2483-2499

2010

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Granulocyte Colony Stimulating Factor Expression in Breast Cancer and Its Association with Carbonic Anhydrase IX and Immune Checkpoints

Cancers, 2021-03, Vol.13 (5), p.1022

2021

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Nuclear-cytoplasmic trafficking of NTF2, the nuclear import receptor for the RanGTPase, is subjected to regulation

PloS one, 2012-08, Vol.7 (8), p.e42501-e42501

2012

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Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles

Cancer & metabolism, 2024-10, Vol.12 (1), p.28-13, Article 28

2024

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Hydrogen-deuterium exchange mass spectrometry reveals three unique binding responses of mAbs directed to the catalytic domain of hCAIX

mAbs, 2021-01, Vol.13 (1), p.1997072-1997072

2021

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Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia

Gastroenterology (New York, N.Y. 1943), 2019-09, Vol.157 (3), p.823-837

2019

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A Carbonic Anhydrase IX/SLC1A5 axis regulates glutamine metabolism dependent ferroptosis in hypoxic tumor cells

Molecular cancer therapeutics, 2023-10, Vol.22 (10), p.1228-1242

2023

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Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma

Cancer cell, 2022-12, Vol.40 (12), p.1488-1502.e7

2022

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Intratumoral Delivery of Chimeric Antigen Receptor T Cells Targeting CD133 Effectively Treats Brain Metastases

Clinical cancer research, 2024-02, Vol.30 (3), p.554-563

2024

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Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors

Science advances, 2021-08, Vol.7 (35)

2021

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Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer

Cell reports. Medicine, 2020-11, Vol.1 (8), p.100131, Article 100131

2020

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Syntaxin4-Munc18c Interaction Promotes Breast Tumor Invasion and Metastasis by Regulating MT1-MMP Trafficking

Molecular cancer research, 2022-03, Vol.20 (3), p.434-445

2022

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Carving out its niche: A role for carbonic anhydrase IX in pre-metastatic niche development

Oncoimmunology, 2015-12, Vol.4 (12), p.e1048955-e1048955

2015

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De novo GTP synthesis is a metabolic vulnerability for the interception of brain metastases

Cell reports. Medicine, 2024-10, Vol.5 (10), p.101755, Article 101755

2024

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Nutrient stress does not cause retrograde transport of cytoplasmic tRNA to the nucleus in evolutionarily diverse organisms

Molecular biology of the cell, 2011-04, Vol.22 (7), p.1091-1103

2011

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Abstract C053: BACE1 cleaves EGFR to drive lung adenocarcinoma brain metastasis

Molecular cancer therapeutics, 2023-12, Vol.22 (12_Supplement), p.C053-C053

2023

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Abstract A109: Targeting pyrimidine biosynthesis as a metabolic vulnerability in brain metastasis

Molecular cancer therapeutics, 2023-12, Vol.22 (12_Supplement), p.A109-A109

2023

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Cancer Therapeutic Targeting of Hypoxia Induced Carbonic Anhydrase IX: From Bench to Bedside

Carbonic anhydrase IX promotes myeloid-derived suppressor cell mobilization and establishment of a metastatic niche by stimulating G-CSF production

Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors

Targeting Hypoxia-Induced Carbonic Anhydrase IX Enhances Immune-Checkpoint Blockade Locally and Systemically

Overcoming Hypoxia-Mediated Tumor Progression: Combinatorial Approaches Targeting pH Regulation, Angiogenesis and Immune Dysfunction

Dual Antigen T Cell Engagers Targeting CA9 as an Effective Immunotherapeutic Modality for Targeting CA9 in Solid Tumors

Scyl1 facilitates nuclear tRNA export in mammalian cells by acting at the nuclear pore complex

Granulocyte Colony Stimulating Factor Expression in Breast Cancer and Its Association with Carbonic Anhydrase IX and Immune Checkpoints

Nuclear-cytoplasmic trafficking of NTF2, the nuclear import receptor for the RanGTPase, is subjected to regulation

Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles

Hydrogen-deuterium exchange mass spectrometry reveals three unique binding responses of mAbs directed to the catalytic domain of hCAIX

Regulation of pH by Carbonic Anhydrase 9 Mediates Survival of Pancreatic Cancer Cells With Activated KRAS in Response to Hypoxia

A Carbonic Anhydrase IX/SLC1A5 axis regulates glutamine metabolism dependent ferroptosis in hypoxic tumor cells

Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma

Intratumoral Delivery of Chimeric Antigen Receptor T Cells Targeting CD133 Effectively Treats Brain Metastases

Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors

Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer

Syntaxin4-Munc18c Interaction Promotes Breast Tumor Invasion and Metastasis by Regulating MT1-MMP Trafficking

Targeting axonal guidance dependencies in glioblastoma with ROBO1 CAR T cells

Carving out its niche: A role for carbonic anhydrase IX in pre-metastatic niche development

De novo GTP synthesis is a metabolic vulnerability for the interception of brain metastases

Isolation and characterization of monoclonal antibodies against human carbonic anhydrase-IX

Nutrient stress does not cause retrograde transport of cytoplasmic tRNA to the nucleus in evolutionarily diverse organisms

Abstract C053: BACE1 cleaves EGFR to drive lung adenocarcinoma brain metastasis

Abstract A109: Targeting pyrimidine biosynthesis as a metabolic vulnerability in brain metastasis

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