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The promises and pitfalls of RNA-interference-based therapeutics

Nature, 2009-01, Vol.457 (7228), p.426-433

2009

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A cytoplasmic pathway for gapmer antisense oligonucleotide-mediated gene silencing in mammalian cells

Nucleic acids research, 2015-10, Vol.43 (19), p.9350-9361

2015

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A stress-induced response complex (SIRC) shuttles miRNAs, siRNAs, and oligonucleotides to the nucleus

Proceedings of the National Academy of Sciences - PNAS, 2018-06, Vol.115 (25), p.E5756-E5765

2018

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CRM1 mediates nuclear-cytoplasmic shuttling of mature microRNAs

Proceedings of the National Academy of Sciences - PNAS, 2009-12, Vol.106 (51), p.21655-21659

2009

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Defibrotide (Defitelio): A New Addition to the Stockpile of Food and Drug Administration-approved Oligonucleotide Drugs

Molecular therapy. Nucleic acids, 2016, Vol.5 (8), p.e346-e346, Article e346

2016

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A Multifunctional LNA Oligonucleotide-Based Strategy Blocks AR Expression and Transactivation Activity in PCa Cells

Molecular therapy. Nucleic acids, 2021-03, Vol.23, p.63-75

2021

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Short hairpin RNA-directed cytosine (CpG) methylation of the RASSF1A gene promoter in HeLa cells

Molecular therapy, 2005-07, Vol.12 (1), p.179-183

2005

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Oligonucleotides to the (Gene) Rescue: FDA Approvals 2017–2019

Trends in pharmacological sciences (Regular ed.), 2020-01, Vol.41 (1), p.27-41

2020

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Endogenous Expression of an Anti-TAR Aptamer Reduces HIV-1 Replication

RNA (Cambridge), 2006-10, Vol.3 (4), p.150-156

2006

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Sensor and Sensitivity: A Screen for Elite shRNAs

Molecular therapy, 2011-05, Vol.19 (5), p.823-825

Castanotto, Daniela

2011

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6BIO Enhances Oligonucleotide Activity in Cells: A Potential Combinatorial Anti-androgen Receptor Therapy in Prostate Cancer Cells

Molecular therapy, 2017-01, Vol.25 (1), p.79-91

2017

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Regulation of monocyte chemoattractant protein-1 by the oxidized lipid, 13-hydroperoxyoctadecadienoic acid, in vascular smooth muscle cells via nuclear factor–kappa B (NF-кB)

Journal of molecular and cellular cardiology, 2004-04, Vol.36 (4), p.585-595

2004

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Incorporation of aptamers in the terminal loop of shRNAs yields an effective and novel combinatorial targeting strategy

Nucleic acids research, 2018-01, Vol.46 (1), p.e6-e6

2018

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TIPZy (Testosterone Increase Post Zytiga): Increase in serum levels of testosterone (T) after treatment of patients with abiraterone acetate (A) and prednisone (P)

Journal of clinical oncology, 2018-05, Vol.36 (15_suppl), p.e17025-e17025

2018

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Amplification of RNAi—Targeting HLA mRNAs

Molecular therapy, 2005-05, Vol.11 (5), p.811-818

2005

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Bcl-2 Protein in 518A2 Melanoma Cells In vivo and In vitro

Clinical cancer research, 2006-08, Vol.12 (16), p.4940-4948

2006

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Ammonium and arsenic trioxide are potent facilitators of oligonucleotide function when delivered by gymnosis

Nucleic acids research, 2018-04, Vol.46 (7), p.3612-3624

2018

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Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC

Nucleic acids research, 2007-08, Vol.35 (15), p.5154-5164

2007

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Protein Kinase C-α is a Critical Protein for Antisense Oligonucleotide-mediated Silencing in Mammalian Cells

Molecular therapy, 2016-06, Vol.24 (6), p.1117-1125

2016

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Protein Kinase C-[alpha] is a Critical Protein for Antisense Oligonucleotide-mediated Silencing in Mammalian Cells

Molecular therapy, 2016-06, Vol.24 (6), p.1117

2016

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692. A Novel RNAi Trigger Design Retains Potent, Target Specific Activity Despite Emerging Mutations in the Target Site

Molecular therapy, 2015-05, Vol.23, p.S276-S276

2015

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The promises and pitfalls of RNA-interference-based therapeutics : RNA SILENCING

Nature (London), 2009, Vol.457 (7228), p.426-433

2009

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Functional siRNA expression from transfected PCR products

RNA (Cambridge), 2002-11, Vol.8 (11), p.1454-1460, Article S1355838202021362

2002

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Inhibition of HIV-1 infection by lentiviral vectors expressing pol III-promoted anti-HIV RNAs

Molecular therapy, 2003-08, Vol.8 (2), p.196-206

2003

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RNA-Mediated Inhibition of HIV in a Gene Therapy Setting

Annals of the New York Academy of Sciences, 2003-12, Vol.1002 (1), p.63-71

2003

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The promises and pitfalls of RNA-interference-based therapeutics

A cytoplasmic pathway for gapmer antisense oligonucleotide-mediated gene silencing in mammalian cells

A stress-induced response complex (SIRC) shuttles miRNAs, siRNAs, and oligonucleotides to the nucleus

CRM1 mediates nuclear-cytoplasmic shuttling of mature microRNAs

Defibrotide (Defitelio): A New Addition to the Stockpile of Food and Drug Administration-approved Oligonucleotide Drugs

A Multifunctional LNA Oligonucleotide-Based Strategy Blocks AR Expression and Transactivation Activity in PCa Cells

Short hairpin RNA-directed cytosine (CpG) methylation of the RASSF1A gene promoter in HeLa cells

Oligonucleotides to the (Gene) Rescue: FDA Approvals 2017–2019

Endogenous Expression of an Anti-TAR Aptamer Reduces HIV-1 Replication

Sensor and Sensitivity: A Screen for Elite shRNAs

6BIO Enhances Oligonucleotide Activity in Cells: A Potential Combinatorial Anti-androgen Receptor Therapy in Prostate Cancer Cells

Regulation of monocyte chemoattractant protein-1 by the oxidized lipid, 13-hydroperoxyoctadecadienoic acid, in vascular smooth muscle cells via nuclear factor–kappa B (NF-кB)

Incorporation of aptamers in the terminal loop of shRNAs yields an effective and novel combinatorial targeting strategy

TIPZy (Testosterone Increase Post Zytiga): Increase in serum levels of testosterone (T) after treatment of patients with abiraterone acetate (A) and prednisone (P)

Amplification of RNAi—Targeting HLA mRNAs

Bcl-2 Protein in 518A2 Melanoma Cells In vivo and In vitro

Ammonium and arsenic trioxide are potent facilitators of oligonucleotide function when delivered by gymnosis

Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC

Protein Kinase C-α is a Critical Protein for Antisense Oligonucleotide-mediated Silencing in Mammalian Cells

Protein Kinase C-[alpha] is a Critical Protein for Antisense Oligonucleotide-mediated Silencing in Mammalian Cells

692. A Novel RNAi Trigger Design Retains Potent, Target Specific Activity Despite Emerging Mutations in the Target Site

The promises and pitfalls of RNA-interference-based therapeutics : RNA SILENCING

Functional siRNA expression from transfected PCR products

Inhibition of HIV-1 infection by lentiviral vectors expressing pol III-promoted anti-HIV RNAs

RNA-Mediated Inhibition of HIV in a Gene Therapy Setting

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