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Disrupting the scaffold to improve focal adhesion kinase-targeted cancer therapeutics

Science signaling, 2013-03, Vol.6 (268), p.pe10

2013

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A Small Molecule Inhibitor, 1,2,4,5-Benzenetetraamine Tetrahydrochloride, Targeting the Y397 Site of Focal Adhesion Kinase Decreases Tumor Growth

Journal of medicinal chemistry, 2008-12, Vol.51 (23), p.7405-7416

2008

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MiR-138 and MiR-135 directly target focal adhesion kinase, inhibit cell invasion, and increase sensitivity to chemotherapy in cancer cells

Anti-cancer agents in medicinal chemistry, 2014-01, Vol.14 (1), p.18

2014

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FAK and p53 protein interactions

Anti-cancer agents in medicinal chemistry, 2011-09, Vol.11 (7), p.617

2011

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Focal adhesion kinase versus p53: apoptosis or survival?

Science signaling, 2008-05, Vol.1 (20), p.pe22

2008

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A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer

Cell cycle (Georgetown, Tex.), 2009-08, Vol.8 (15), p.2435-2443

2009

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Oncogenic Receptor Tyrosine Kinases Directly Phosphorylate Focal Adhesion Kinase (FAK) as a Resistance Mechanism to FAK-Kinase Inhibitors

Molecular cancer therapeutics, 2016-12, Vol.15 (12), p.3028-3039

2016

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Direct Interaction of the N-terminal Domain of Focal Adhesion Kinase with the N-terminal Transactivation Domain of p53

The Journal of biological chemistry, 2005-07, Vol.280 (26), p.25008-25021

2005

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FAK and HAS inhibition synergistically decrease colon cancer cell viability and affect expression of critical genes

Anti-cancer agents in medicinal chemistry, 2013-05, Vol.13 (4), p.584

2013

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Annual report to the nation on the status of cancer, part 1: National cancer statistics

Cancer, 2022-12, Vol.128 (24), p.4251-4284

2022

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FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells

Carcinogenesis (New York), 2008-06, Vol.29 (6), p.1096-1107

2008

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A small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo

Anti-cancer agents in medicinal chemistry, 2013-05, Vol.13 (4), p.532

2013

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Targeting the p53 pathway

Surgical oncology clinics of North America, 2013-10, Vol.22 (4), p.747

2013

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Mitoxantrone targets the ATP-binding site of FAK, binds the FAK kinase domain and decreases FAK, Pyk-2, c-Src, and IGF-1R in vitro kinase activities

Anti-cancer agents in medicinal chemistry, 2013-05, Vol.13 (4), p.546

2013

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Retroperitoneal soft tissue sarcoma

Cancer, 2005-08, Vol.104 (4), p.669-675

2005

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The direct effect of focal adhesion kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis

BMC cancer, 2009-08, Vol.9 (1), p.280-280, Article 280

2009

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American Cancer Society's report on the status of cancer disparities in the United States, 2021

CA: a cancer journal for clinicians, 2022-03, Vol.72 (2), p.112-143

2022

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FAK overexpression and p53 mutations are highly correlated in human breast cancer

International journal of cancer, 2009-10, Vol.125 (7), p.1735-1738

2009

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Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma

Cell cycle (Georgetown, Tex.), 2010-03, Vol.9 (5), p.1005-1015

2010

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Down-regulation of ALDH1A3, CD44 or MDR1 sensitizes resistant cancer cells to FAK autophosphorylation inhibitor Y15

Journal of cancer research and clinical oncology, 2015-09, Vol.141 (9), p.1613-1631

2015

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Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth

Cell cycle (Georgetown, Tex.), 2012-09, Vol.11 (17), p.3250-3259

2012

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Focal Adhesion Kinase Suppresses Apoptosis by Binding to the Death Domain of Receptor-Interacting Protein

Molecular and Cellular Biology, 2004-05, Vol.24 (10), p.4361-4371

2004

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p53 regulates FAK expression in human tumor cells

Molecular carcinogenesis, 2008-05, Vol.47 (5), p.373-382

2008

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Blueprint for cancer research: Critical gaps and opportunities

CA: a cancer journal for clinicians, 2021-03, Vol.71 (2), p.107-139

2021

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Focal Adhesion Kinase Expression in Human Neuroblastoma: Immunohistochemical and Real-time PCR Analyses

Clinical cancer research, 2008-06, Vol.14 (11), p.3299-3305

2008

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Disrupting the scaffold to improve focal adhesion kinase-targeted cancer therapeutics

A Small Molecule Inhibitor, 1,2,4,5-Benzenetetraamine Tetrahydrochloride, Targeting the Y397 Site of Focal Adhesion Kinase Decreases Tumor Growth

MiR-138 and MiR-135 directly target focal adhesion kinase, inhibit cell invasion, and increase sensitivity to chemotherapy in cancer cells

FAK and p53 protein interactions

Focal adhesion kinase versus p53: apoptosis or survival?

A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer

Oncogenic Receptor Tyrosine Kinases Directly Phosphorylate Focal Adhesion Kinase (FAK) as a Resistance Mechanism to FAK-Kinase Inhibitors

Direct Interaction of the N-terminal Domain of Focal Adhesion Kinase with the N-terminal Transactivation Domain of p53

FAK and HAS inhibition synergistically decrease colon cancer cell viability and affect expression of critical genes

Annual report to the nation on the status of cancer, part 1: National cancer statistics

FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells

A small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo

Targeting the p53 pathway

Mitoxantrone targets the ATP-binding site of FAK, binds the FAK kinase domain and decreases FAK, Pyk-2, c-Src, and IGF-1R in vitro kinase activities

Retroperitoneal soft tissue sarcoma

The direct effect of focal adhesion kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis

American Cancer Society's report on the status of cancer disparities in the United States, 2021

FAK overexpression and p53 mutations are highly correlated in human breast cancer

Inhibition of focal adhesion kinase decreases tumor growth in human neuroblastoma

Down-regulation of ALDH1A3, CD44 or MDR1 sensitizes resistant cancer cells to FAK autophosphorylation inhibitor Y15

Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth

Focal Adhesion Kinase Suppresses Apoptosis by Binding to the Death Domain of Receptor-Interacting Protein

p53 regulates FAK expression in human tumor cells

Blueprint for cancer research: Critical gaps and opportunities

Focal Adhesion Kinase Expression in Human Neuroblastoma: Immunohistochemical and Real-time PCR Analyses

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