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Combining Antivirals and Immunomodulators to Fight COVID-19

Trends in immunology, 2021-01, Vol.42 (1), p.31-44

2021

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Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis

Nature communications, 2020-09, Vol.11 (1), p.1-9, Article 4682

2020

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Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA

Proceedings of the National Academy of Sciences - PNAS, 2018-01, Vol.115 (2), p.E162-E171

2018

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A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase

Nature communications, 2022-02, Vol.13 (1), p.621-621, Article 621

2022

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RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex

Proceedings of the National Academy of Sciences - PNAS, 2012-06, Vol.109 (24), p.9372-9377

2012

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The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity

Frontiers in microbiology, 2019-08, Vol.10, p.1813-1813

2019

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One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

Proceedings of the National Academy of Sciences - PNAS, 2014-09, Vol.111 (37), p.E3900-E3909

2014

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Snapshots of ADP-ribose bound to Getah virus macro domain reveal an intriguing choreography

Scientific reports, 2020-09, Vol.10 (1), p.14422-14422, Article 14422

2020

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SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

Nature immunology, 2012-03, Vol.13 (3), p.223-228

2012

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Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective

eLife, 2021-10, Vol.10

2021

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In vitro reconstitution of SARS-coronavirus mRNA cap methylation

PLoS pathogens, 2010-04, Vol.6 (4), p.e1000863-e1000863

2010

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Filovirus proteins for antiviral drug discovery: A structure/function analysis of surface glycoproteins and virus entry

Antiviral research, 2016-11, Vol.135, p.1-14

2016

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Viral Instant Mutation Viewer: A Tool to Speed Up the Identification and Analysis of New SARS-CoV-2 Emerging Variants and Beyond

Viruses, 2023-07, Vol.15 (8), p.1628

2023

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Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2'-O-methyltransferase nsp10/nsp16 complex

PLoS pathogens, 2011-05, Vol.7 (5), p.e1002059-e1002059

2011

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The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain

Nucleic acids research, 2014-10, Vol.42 (18), p.11642-11656

2014

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Regulation of Flavivirus RNA synthesis and replication

Current opinion in virology, 2014-12, Vol.9, p.74-83

2014

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Structural and Functional Basis of the Fidelity of Nucleotide Selection by Flavivirus RNA-Dependent RNA Polymerases

Viruses, 2018-01, Vol.10 (2), p.59

2018

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Coronavirus Nsp10, a Critical Co-factor for Activation of Multiple Replicative Enzymes

The Journal of biological chemistry, 2014-09, Vol.289 (37), p.25783-25796

2014

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Discovery of an RNA Virus 3'→5' Exoribonuclease That Is Critically Involved in Coronavirus RNA Synthesis

Proceedings of the National Academy of Sciences - PNAS, 2006-03, Vol.103 (13), p.5108-5113

2006

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The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution

PLoS biology, 2024-08, Vol.22 (8), p.e3002743

2024

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Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase

Journal of virology, 2017-06, Vol.91 (12), p.e00487-17

2017

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Nuclear Localization of Dengue Virus Nonstructural Protein 5 Does Not Strictly Correlate with Efficient Viral RNA Replication and Inhibition of Type I Interferon Signaling

Journal of Virology, 2013-04, Vol.87 (8), p.4545-4557

2013

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Structural biology in the fight against COVID-19

Nature structural & molecular biology, 2021-01, Vol.28 (1), p.2-7

2021

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Crystal Structure of the Dengue Virus RNA-Dependent RNA Polymerase Catalytic Domain at 1.85-Angstrom Resolution

Journal of Virology, 2007-05, Vol.81 (9), p.4753-4765

2007

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Mutations on VEEV nsP1 relate RNA capping efficiency to ribavirin susceptibility

Antiviral research, 2020-10, Vol.182, p.104883-104883, Article 104883

2020

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Combining Antivirals and Immunomodulators to Fight COVID-19

Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis

Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA

A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase

RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex

The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity

One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

Snapshots of ADP-ribose bound to Getah virus macro domain reveal an intriguing choreography

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

Inhibition of SARS-CoV-2 polymerase by nucleotide analogs from a single-molecule perspective

In vitro reconstitution of SARS-coronavirus mRNA cap methylation

Filovirus proteins for antiviral drug discovery: A structure/function analysis of surface glycoproteins and virus entry

Viral Instant Mutation Viewer: A Tool to Speed Up the Identification and Analysis of New SARS-CoV-2 Emerging Variants and Beyond

Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2'-O-methyltransferase nsp10/nsp16 complex

The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain

Regulation of Flavivirus RNA synthesis and replication

Structural and Functional Basis of the Fidelity of Nucleotide Selection by Flavivirus RNA-Dependent RNA Polymerases

Coronavirus Nsp10, a Critical Co-factor for Activation of Multiple Replicative Enzymes

Discovery of an RNA Virus 3'→5' Exoribonuclease That Is Critically Involved in Coronavirus RNA Synthesis

The activation cascade of the broad-spectrum antiviral bemnifosbuvir characterized at atomic resolution

Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase

Nuclear Localization of Dengue Virus Nonstructural Protein 5 Does Not Strictly Correlate with Efficient Viral RNA Replication and Inhibition of Type I Interferon Signaling

Structural biology in the fight against COVID-19

Crystal Structure of the Dengue Virus RNA-Dependent RNA Polymerase Catalytic Domain at 1.85-Angstrom Resolution

Mutations on VEEV nsP1 relate RNA capping efficiency to ribavirin susceptibility

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