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Basis for the discrimination of supercoil handedness during DNA cleavage by human and bacterial type II topoisomerases

Nucleic acids research, 2023-05, Vol.51 (8), p.3888

2023

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Genome-wide TOP2A DNA cleavage is biased toward translocated and highly transcribed loci

Genome research, 2017-07, Vol.27 (7), p.1238

2017

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Topoisomerase II Is Crucial for Fork Convergence during Vertebrate Replication Termination

Cell reports (Cambridge), 2019-10, Vol.29 (2), p.422-436.e5

2019

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Actions of a Novel Bacterial Topoisomerase Inhibitor against Neisseria gonorrhoeae Gyrase and Topoisomerase IV: Enhancement of Double-Stranded DNA Breaks

International journal of molecular sciences, 2023-07, Vol.24 (15), p.12107

2023

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Interlinked DNA nano-circles for measuring topoisomerase II activity at the level of single decatenation events

Nucleic acids research, 2017-07, Vol.45 (13), p.7855

2017

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Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II

PloS one, 2010-04, Vol.5 (4), p.e10186

2010

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DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA

Proceedings of the National Academy of Sciences - PNAS, 2012-02, Vol.109 (8), p.2925-2930

2012

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Direct monitoring of the strand passage reaction of DNA topoisomerase II triggers checkpoint activation

PLoS genetics, 2013-10, Vol.9 (10), p.e1003832

2013

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Synthesis and Cytotoxic Evaluation of Arimetamycin A and Its Daunorubicin and Doxorubicin Hybrids

ACS central science, 2021-08, Vol.7 (8), p.1327-1337

2021

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Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms

The EMBO journal, 2022-06, Vol.41 (12), p.e110632-n/a

2022

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Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity

Journal of medicinal chemistry, 2022-05, Vol.65 (9), p.6903-6925

2022

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First Ruthenium Organometallic Complex of Antibacterial Agent Ofloxacin. Crystal Structure and Interactions with DNA

Inorganic chemistry, 2010-12, Vol.49 (23), p.10750-10752

2010

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Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β

Journal of medicinal chemistry, 2020-11, Vol.63 (21), p.12873-12886

2020

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Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα

Bioorganic & medicinal chemistry letters, 2017-10, Vol.27 (20), p.4687-4693

2017

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Etoposide Quinone Is a Covalent Poison of Human Topoisomerase IIβ

Biochemistry (Easton), 2014-05, Vol.53 (19), p.3229-3236

2014

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Selection of DNA Cleavage Sites by Topoisomerase II Results from Enzyme-Induced Flexibility of DNA

Cell chemical biology, 2019-04, Vol.26 (4), p.502-511.e3

2019

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A Series of Spiropyrimidinetriones that Enhances DNA Cleavage Mediated by Mycobacterium tuberculosis Gyrase

ACS infectious diseases, 2023-03, Vol.9 (3), p.706-715

2023

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Epimerization of Green Tea Catechins during Brewing Does Not Affect the Ability to Poison Human Type II Topoisomerases

Chemical research in toxicology, 2013-04, Vol.26 (4), p.622-628

2013

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Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia

Blood, 2010-01, Vol.115 (2), p.326-330

2010

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Abstract 1657 Interactions of established and novel antibacterials with Acinetobacter baumannii gyrase and topoisomerase IV

The Journal of biological chemistry, 2024-03, Vol.300 (3), p.105856, Article 105856

2024

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DNA Topoisomerases as Targets for the Anticancer Drug TAS-103: Primary Cellular Target and DNA Cleavage Enhancement

Biochemistry (Easton), 1999-11, Vol.38 (47), p.15573-15579

1999

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DNA supercoil geometry differentially affects the stability of DNA cleavage complexes formed by different type II topoisomerases

The FASEB journal, 2021-05, Vol.35 (S1), p.n/a, Article fasebj.2021.35.S1.02032

2021

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Abstract 1213: Basis for the Discrimination of Supercoil Handedness During DNA Cleavage by Human and Bacterial Type II Topoisomerases

The Journal of biological chemistry, 2023, Vol.299 (3), p.103458, Article 103458

2023

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DNA Topoisomerase II as the Target for the Anticancer Drug TOP-53: Mechanistic Basis for Drug Action

Biochemistry (Easton), 2001-01, Vol.40 (3), p.712-718

2001

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Basis for the discrimination of supercoil handedness during DNA cleavage by human and bacterial type II topoisomerases

Genome-wide TOP2A DNA cleavage is biased toward translocated and highly transcribed loci

Topoisomerase II Is Crucial for Fork Convergence during Vertebrate Replication Termination

Actions of a Novel Bacterial Topoisomerase Inhibitor against Neisseria gonorrhoeae Gyrase and Topoisomerase IV: Enhancement of Double-Stranded DNA Breaks

Interlinked DNA nano-circles for measuring topoisomerase II activity at the level of single decatenation events

Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II

DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA

Direct monitoring of the strand passage reaction of DNA topoisomerase II triggers checkpoint activation

Synthesis and Cytotoxic Evaluation of Arimetamycin A and Its Daunorubicin and Doxorubicin Hybrids

Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms

Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity

First Ruthenium Organometallic Complex of Antibacterial Agent Ofloxacin. Crystal Structure and Interactions with DNA

Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β

Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα

Etoposide Quinone Is a Covalent Poison of Human Topoisomerase IIβ

Selection of DNA Cleavage Sites by Topoisomerase II Results from Enzyme-Induced Flexibility of DNA

A Series of Spiropyrimidinetriones that Enhances DNA Cleavage Mediated by Mycobacterium tuberculosis Gyrase

Epimerization of Green Tea Catechins during Brewing Does Not Affect the Ability to Poison Human Type II Topoisomerases

Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia

Molecular analysis of t(15;17) genomic breakpoints in secondary acute promyelocytic leukemia arising after treatment of multiple sclerosis

Abstract 1657 Interactions of established and novel antibacterials with Acinetobacter baumannii gyrase and topoisomerase IV

DNA Topoisomerases as Targets for the Anticancer Drug TAS-103: Primary Cellular Target and DNA Cleavage Enhancement

DNA supercoil geometry differentially affects the stability of DNA cleavage complexes formed by different type II topoisomerases

Abstract 1213: Basis for the Discrimination of Supercoil Handedness During DNA Cleavage by Human and Bacterial Type II Topoisomerases

DNA Topoisomerase II as the Target for the Anticancer Drug TOP-53: Mechanistic Basis for Drug Action

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