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C–H activation reactions as useful tools for medicinal chemists

Bioorganic & medicinal chemistry letters, 2016-11, Vol.26 (22), p.5378-5383

2016

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GPR119 agonists for the treatment of type 2 diabetes

Expert opinion on therapeutic patents, 2009-10, Vol.19 (10), p.1339-1359

2009

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Therapeutic Utility of Cannabinoid Receptor Type 2 (CB2) Selective Agonists

Journal of medicinal chemistry, 2013-11, Vol.56 (21), p.8224-8256

2013

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Identification of 2-arylbenzimidazoles as potent human histamine H4 receptor ligands

Bioorganic & medicinal chemistry letters, 2006-12, Vol.16 (23), p.6043-6048

2006

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Recent progress in the development of selective S1P1 receptor agonists for the treatment of inflammatory and autoimmune disorders

Expert opinion on therapeutic patents, 2008-10, Vol.18 (10), p.1141-1159

2008

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Kinetics of 5-HT2B receptor signaling: profound agonist-dependent effects on signaling onset and duration

The Journal of pharmacology and experimental therapeutics, 2013-12, Vol.347 (3), p.645

2013

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Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate‑1 Receptor

ACS medicinal chemistry letters, 2014-12, Vol.5 (12), p.1313-1317

2014

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Design and synthesis of new tricyclic indoles as potent modulators of the S1P1 receptor

Bioorganic & medicinal chemistry letters, 2015-02, Vol.25 (3), p.659-663

2015

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An Efficient Scale-Up Process for the Preparation of the APD334 Precursor 4‑Chloromethyl-1-cyclopentyl-2-(trifluoromethyl)benzene

Organic process research & development, 2015-06, Vol.19 (6), p.618-623

2015

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Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series

Bioorganic & medicinal chemistry letters, 2015-08, Vol.25 (15), p.3034-3038

2015

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Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists

Bioorganic & medicinal chemistry letters, 2014-09, Vol.24 (17), p.4332-4335

2014

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Agonist/antagonist modulation in a series of 2-aryl benzimidazole H4 receptor ligands

Bioorganic & medicinal chemistry letters, 2010-06, Vol.20 (11), p.3367-3371

2010

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GPR119 agonists 2009-2011

Pharmaceutical patent analyst, 2012-07, Vol.1 (3), p.285-299

2012

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Synthesis of a Broad Array of Highly Functionalized, Enantiomerically Pure Cyclohexanecarboxylic Acid Derivatives by Microbial Dihydroxylation of Benzoic Acid and Subsequent Oxidative and Rearrangement Reactions

Organic letters, 2001-09, Vol.3 (18), p.2923-2926

2001

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Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease

Bioorganic & medicinal chemistry letters, 2012-07, Vol.22 (13), p.4404-4409

2012

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Design and synthesis of new tricyclic indoles as potent modulators of the S1P sub(1) receptor

Bioorganic & medicinal chemistry letters, 2015-02, Vol.25 (3), p.659-663

2015

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ChemInform Abstract: C—H Activation Reactions as Useful Tools for Medicinal Chemists

ChemInform, 2016-12, Vol.47 (51), p.no-no

2016

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Identification of 2-arylbenzimidazoles as potent human histamine H 4 receptor ligands

Bioorganic & medicinal chemistry letters, 2006-12, Vol.16 (23), p.6043-6048

2006

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Agonist/antagonist modulation in a series of 2-aryl benzimidazole H sub(4) receptor ligands

Bioorganic & medicinal chemistry letters, 2010-06, Vol.20 (11), p.3367-3371

2010

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Identification of 2-arylbenzimidazoles as potent human histamine H sub(4) receptor ligands

Bioorganic & medicinal chemistry letters, 2006-12, Vol.16 (23), p.6043-6048

2006

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Alkylations of Functionalized Organozinc Reagents with Allylic Epoxides Catalyzed by A Cyanocuprate

Synlett, 1997, Vol.1997 (Sup. I), p.477-478

1997

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Cuprate-catalyzed Three-Component Couplings of Functionalized Organozinc Reagents

Journal of the Chinese Chemical Society (Taipei), 1997-02, Vol.44 (1), p.1-4

1997

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ChemInform Abstract: Synthesis of a Broad Array of Highly Functionalized, Enantiomerically Pure Cyclohexanecarboxylic Acid Derivatives by Microbial Dihydroxylation of Benzoic Acid and Subsequent Oxidative and Rearrangement Reactions

ChemInform, 2002-01, Vol.33 (2), p.no-no

2002

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C–H activation reactions as useful tools for medicinal chemists

GPR119 agonists for the treatment of type 2 diabetes

Therapeutic Utility of Cannabinoid Receptor Type 2 (CB2) Selective Agonists

Identification of 2-arylbenzimidazoles as potent human histamine H4 receptor ligands

Recent progress in the development of selective S1P1 receptor agonists for the treatment of inflammatory and autoimmune disorders

Kinetics of 5-HT2B receptor signaling: profound agonist-dependent effects on signaling onset and duration

Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate‑1 Receptor

Design and synthesis of new tricyclic indoles as potent modulators of the S1P1 receptor

An Efficient Scale-Up Process for the Preparation of the APD334 Precursor 4‑Chloromethyl-1-cyclopentyl-2-(trifluoromethyl)benzene

Discovery of a novel trans-1,4-dioxycyclohexane GPR119 agonist series

Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists

Agonist/antagonist modulation in a series of 2-aryl benzimidazole H4 receptor ligands

(7‑Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2‑a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists

GPR119 agonists 2009-2011

Synthesis of a Broad Array of Highly Functionalized, Enantiomerically Pure Cyclohexanecarboxylic Acid Derivatives by Microbial Dihydroxylation of Benzoic Acid and Subsequent Oxidative and Rearrangement Reactions

Fused tricyclic indoles as S1P1 agonists with robust efficacy in animal models of autoimmune disease

Design and synthesis of new tricyclic indoles as potent modulators of the S1P sub(1) receptor

ChemInform Abstract: C—H Activation Reactions as Useful Tools for Medicinal Chemists

Identification of 2-arylbenzimidazoles as potent human histamine H 4 receptor ligands

Agonist/antagonist modulation in a series of 2-aryl benzimidazole H sub(4) receptor ligands

(7-Benzyloxy-2,3-dihydro- 1H -pyrrolo[1,2- a ]indol-1-yl)acetic Acids as S1P 1 Functional Antagonists

Identification of 2-arylbenzimidazoles as potent human histamine H sub(4) receptor ligands

Alkylations of Functionalized Organozinc Reagents with Allylic Epoxides Catalyzed by A Cyanocuprate

Cuprate-catalyzed Three-Component Couplings of Functionalized Organozinc Reagents

ChemInform Abstract: Synthesis of a Broad Array of Highly Functionalized, Enantiomerically Pure Cyclohexanecarboxylic Acid Derivatives by Microbial Dihydroxylation of Benzoic Acid and Subsequent Oxidative and Rearrangement Reactions

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