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C6 Hydroxymethyl-Substituted Carbapenem MA-1-206 Inhibits the Major Acinetobacter baumannii Carbapenemase OXA-23 by Impeding Deacylation

mBio, 2022-04, Vol.13 (3), p.e0036722-e0036722

2022

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Crystal Structures of KPC-2 β-Lactamase in Complex with 3-Nitrophenyl Boronic Acid and the Penam Sulfone PSR-3-226

Antimicrobial Agents and Chemotherapy, 2012-05, Vol.56 (5), p.2713-2718

2012

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Early Insights into the Interactions of Different β-Lactam Antibiotics and β-Lactamase Inhibitors against Soluble Forms of Acinetobacter baumannii PBP1a and Acinetobacter sp. PBP3

Antimicrobial Agents and Chemotherapy, 2012-11, Vol.56 (11), p.5687-5692

2012

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Stereoselective ketone reduction by a carbonyl reductase from Sporobolomyces salmonicolor. Substrate specificity, enantioselectivity and enzyme-substrate docking studies

Organic & biomolecular chemistry, 2006-01, Vol.4 (14), p.2690-2695

2006

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β-Lactamase inhibitors: a review of the patent literature (2010 - 2013)

Expert opinion on therapeutic patents, 2013-11, Vol.23 (11), p.1469-1481

Buynak, John D

2013

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Penam sulfones and β-lactamase inhibition: SA2-13 and the importance of the C2 side chain length and composition

PloS one, 2014, Vol.9 (1), p.e85892

2014

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Activity of Imipenem, Meropenem, Cefepime, and Sulbactam in Combination with the β-Lactamase Inhibitor LN-1-255 against Acinetobacter spp

Antibiotics (Basel), 2021-02, Vol.10 (2), p.210

2021

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Triethysilyl enol ethers in the synthesis of carbapenem precursors

Tetrahedron letters, 2015-06, Vol.56 (23), p.3385-3389

2015

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Structures of SHV-1 β-lactamase with penem and penam sulfone inhibitors that form cyclic intermediates stabilized by carbonyl conjugation

PloS one, 2012-11, Vol.7 (11), p.e49035-e49035

2012

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Cutting and Stitching: The Cross-Linking of Peptidoglycan in the Assembly of the Bacterial Cell Wall

ACS chemical biology, 2007-09, Vol.2 (9), p.602-605

Buynak, John D

2007

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Penicillin Sulfone Inhibitors of Class D β-Lactamases

Antimicrobial Agents and Chemotherapy, 2010-04, Vol.54 (4), p.1414-1424

2010

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Ligand-Dependent Disorder of the Ω Loop Observed in Extended-Spectrum SHV-Type β-Lactamase

Antimicrobial Agents and Chemotherapy, 2011-05, Vol.55 (5), p.2303-2309

2011

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Understanding the longevity of the β-lactam antibiotics and of antibiotic/β-lactamase inhibitor combinations

Biochemical pharmacology, 2006-03, Vol.71 (7), p.930-940

Buynak, John D.

2006

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Virtual Screening and Experimental Testing of B1 Metallo-β-lactamase Inhibitors

Journal of chemical information and modeling, 2018-09, Vol.58 (9), p.1902-1914

2018

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Therapeutic Efficacy of LN-1-255 in Combination with Imipenem in Severe Infection Caused by Carbapenem-Resistant Acinetobacter baumannii

Antimicrobial agents and chemotherapy, 2019-10, Vol.63 (10)

2019

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The discovery and development of modified penicillin- and cephalosporin-derived beta-lactamase inhibitors

Current medicinal chemistry, 2004-07, Vol.11 (14), p.1951-1964

Buynak, John D

2004

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An efficient and general urazole synthesis

Tetrahedron letters, 2012-07, Vol.53 (27), p.3514-3517

2012

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Evaluation of β-Lactamase Inhibitors in Disk Tests for Detection of Plasmid-Mediated AmpC β-Lactamases in Well-Characterized Clinical Strains of Klebsiella spp

Journal of Clinical Microbiology, 2005-08, Vol.43 (8), p.4168-4171

2005

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The C5α-Methyl-Substituted Carbapenem NA-1-157 Exhibits Potent Activity against Klebsiella spp. Isolates Producing OXA-48-Type Carbapenemases

ACS infectious diseases, 2023-05, Vol.9 (5), p.1123-1136

2023

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LN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48

Journal of antimicrobial chemotherapy, 2016-08, Vol.71 (8), p.2171-2180

2016

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Restricted Rotational Flexibility of the C5α-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the GES‑5 Carbapenemase

ACS infectious diseases, 2024-04, Vol.10 (4), p.1232-1249

2024

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Heterocyclic Scaffolds I: β-Lactams

Journal of the American Chemical Society, 2011-01, Vol.133 (2), p.388-388

Buynak, John D

2011

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Meropenem and chromacef intermediates observed in IMP-25 metallo-β-lactamase-catalyzed hydrolysis

Antimicrobial agents and chemotherapy, 2015-07, Vol.59 (7), p.4326-4330

2015

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Atypically Modified Carbapenem Antibiotics Display Improved Antimycobacterial Activity in the Absence of β‑Lactamase Inhibitors

ACS infectious diseases, 2021-08, Vol.7 (8), p.2425-2436

2021

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Design, Synthesis, and Crystal Structures of 6-Alkylidene-2′-Substituted Penicillanic Acid Sulfones as Potent Inhibitors of Acinetobacter baumannii OXA-24 Carbapenemase

Journal of the American Chemical Society, 2010-09, Vol.132 (38), p.13320-13331

2010

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C6 Hydroxymethyl-Substituted Carbapenem MA-1-206 Inhibits the Major Acinetobacter baumannii Carbapenemase OXA-23 by Impeding Deacylation

Crystal Structures of KPC-2 β-Lactamase in Complex with 3-Nitrophenyl Boronic Acid and the Penam Sulfone PSR-3-226

Early Insights into the Interactions of Different β-Lactam Antibiotics and β-Lactamase Inhibitors against Soluble Forms of Acinetobacter baumannii PBP1a and Acinetobacter sp. PBP3

Stereoselective ketone reduction by a carbonyl reductase from Sporobolomyces salmonicolor. Substrate specificity, enantioselectivity and enzyme-substrate docking studies

β-Lactamase inhibitors: a review of the patent literature (2010 - 2013)

Penam sulfones and β-lactamase inhibition: SA2-13 and the importance of the C2 side chain length and composition

Activity of Imipenem, Meropenem, Cefepime, and Sulbactam in Combination with the β-Lactamase Inhibitor LN-1-255 against Acinetobacter spp

Triethysilyl enol ethers in the synthesis of carbapenem precursors

Structures of SHV-1 β-lactamase with penem and penam sulfone inhibitors that form cyclic intermediates stabilized by carbonyl conjugation

Cutting and Stitching: The Cross-Linking of Peptidoglycan in the Assembly of the Bacterial Cell Wall

Penicillin Sulfone Inhibitors of Class D β-Lactamases

Ligand-Dependent Disorder of the Ω Loop Observed in Extended-Spectrum SHV-Type β-Lactamase

Understanding the longevity of the β-lactam antibiotics and of antibiotic/β-lactamase inhibitor combinations

Virtual Screening and Experimental Testing of B1 Metallo-β-lactamase Inhibitors

Therapeutic Efficacy of LN-1-255 in Combination with Imipenem in Severe Infection Caused by Carbapenem-Resistant Acinetobacter baumannii

The discovery and development of modified penicillin- and cephalosporin-derived beta-lactamase inhibitors

An efficient and general urazole synthesis

Evaluation of β-Lactamase Inhibitors in Disk Tests for Detection of Plasmid-Mediated AmpC β-Lactamases in Well-Characterized Clinical Strains of Klebsiella spp

The C5α-Methyl-Substituted Carbapenem NA-1-157 Exhibits Potent Activity against Klebsiella spp. Isolates Producing OXA-48-Type Carbapenemases

LN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48

Restricted Rotational Flexibility of the C5α-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the GES‑5 Carbapenemase

Heterocyclic Scaffolds I: β-Lactams

Meropenem and chromacef intermediates observed in IMP-25 metallo-β-lactamase-catalyzed hydrolysis

Atypically Modified Carbapenem Antibiotics Display Improved Antimycobacterial Activity in the Absence of β‑Lactamase Inhibitors

Design, Synthesis, and Crystal Structures of 6-Alkylidene-2′-Substituted Penicillanic Acid Sulfones as Potent Inhibitors of Acinetobacter baumannii OXA-24 Carbapenemase

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