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Imino sugar inhibitors for treating the lysosomal glycosphingolipidoses

Glycobiology (Oxford), 2005-10, Vol.15 (10), p.43R-52R

2005

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A Systematic Investigation of Iminosugar Click Clusters as Pharmacological Chaperones for the Treatment of Gaucher Disease

Chembiochem : a European journal of chemical biology, 2014-01, Vol.15 (2), p.309-319

2014

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Polyhydroxylated Bicyclic Isoureas and Guanidines Are Potent Glucocerebrosidase Inhibitors and Nanomolar Enzyme Activity Enhancers in Gaucher Cells

Journal of the American Chemical Society, 2011-04, Vol.133 (14), p.5474-5484

2011

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Potent Aminocyclitol Glucocerebrosidase Inhibitors are Subnanomolar Pharmacological Chaperones for Treating Gaucher Disease

Journal of medicinal chemistry, 2012-05, Vol.55 (9), p.4479-4488

2012

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Gangliosides play an important role in the organization of CD82-enriched microdomains

Biochemical journal, 2006-12, Vol.400 (2), p.315-325

2006

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Glycosphingolipid synthesis inhibition limits osteoclast activation and myeloma bone disease

The Journal of clinical investigation, 2015-06, Vol.125 (6), p.2279-2292

2015

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Targeting glycosylation as a therapeutic approach

Nature reviews. Drug discovery, 2002-01, Vol.1 (1), p.65-75

2002

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Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase

Proceedings of the National Academy of Sciences - PNAS, 2012-01, Vol.109 (3), p.781-786

2012

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Amphiphilic 1-Deoxynojirimycin Derivatives through Click Strategies for Chemical Chaperoning in N370S Gaucher Cells

Journal of organic chemistry, 2011-10, Vol.76 (19), p.7757-7768

2011

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Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone

Journal of cellular and molecular medicine, 2009-09, Vol.13 (9b), p.3786-3796

2009

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Implications for invariant natural killer T cell ligands due to the restricted presence of isoglobotrihexosylceramide in mammals

Proceedings of the National Academy of Sciences - PNAS, 2007-04, Vol.104 (14), p.5971-5976

2007

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Inhibition of Glycosphingolipid Biosynthesis: Application to Lysosomal Storage Disorders

Chemical reviews, 2000-12, Vol.100 (12), p.4683-4696

2000

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Pharmacotherapeutic strategies using small molecules for the treatment of glycolipid lysosomal storage disorders

Expert opinion on pharmacotherapy, 2007-03, Vol.8 (4), p.427-435

Butters, Terry D

2007

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Rational Design and Synthesis of Highly Potent Pharmacological Chaperones for Treatment of N370S Mutant Gaucher Disease

Journal of medicinal chemistry, 2009-05, Vol.52 (10), p.3146-3149

2009

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Adduction of Cholesterol 5,6-Secosterol Aldehyde to Membrane-Bound Myelin Basic Protein Exposes an Immunodominant Epitope

Biochemistry (Easton), 2011-03, Vol.50 (12), p.2092-2100

2011

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Scalable Syntheses of Both Enantiomers of DNJNAc and DGJNAc from Glucuronolactone: The Effect of N-Alkylation on Hexosaminidase Inhibition

Chemistry : a European journal, 2012-07, Vol.18 (30), p.9341-9359

2012

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Glucosylated free oligosaccharides are biomarkers of endoplasmic- reticulum alpha-glucosidase inhibition

Biochemical journal, 2008-01, Vol.409 (2), p.571-580

2008

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Glycoprotein misfolding in the endoplasmic reticulum: identification of released oligosaccharides reveals a second ER-associated degradation pathway for Golgi-retrieved proteins

Cellular and molecular life sciences : CMLS, 2013-08, Vol.70 (15), p.2799-2814

2013

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Development of a Single Column Method for the Separation of Lipid- and Protein-Derived Oligosaccharides

Journal of proteome research, 2009-02, Vol.8 (2), p.681-687

2009

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Gaucher disease

Current opinion in chemical biology, 2007-08, Vol.11 (4), p.412-418

Butters, Terry D

2007

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Inhibition of α-glucosidase activity by N-deoxynojirimycin analogs in several insect phloem sap feeders

Insect science, 2016-02, Vol.23 (1), p.59-67

2016

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Analysis of fluorescently labeled glycosphingolipid-derived oligosaccharides following ceramide glycanase digestion and anthranilic acid labeling

Analytical biochemistry, 2004-08, Vol.331 (2), p.275-282

2004

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Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain

Organic & biomolecular chemistry, 2011-08, Vol.9 (15), p.5373-5388

2011

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Activation state and intracellular trafficking contribute to the repertoire of endogenous glycosphingolipids presented by CD1d

Proceedings of the National Academy of Sciences - PNAS, 2010-02, Vol.107 (7), p.3052-3057

2010

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A Novel Iminosugar UV-12 with Activity against the Diverse Viruses Influenza and Dengue (Novel Iminosugar Antiviral for Influenza and Dengue)

Viruses, 2015-05, Vol.7 (5), p.2404-2427

2015

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Imino sugar inhibitors for treating the lysosomal glycosphingolipidoses

A Systematic Investigation of Iminosugar Click Clusters as Pharmacological Chaperones for the Treatment of Gaucher Disease

Polyhydroxylated Bicyclic Isoureas and Guanidines Are Potent Glucocerebrosidase Inhibitors and Nanomolar Enzyme Activity Enhancers in Gaucher Cells

Potent Aminocyclitol Glucocerebrosidase Inhibitors are Subnanomolar Pharmacological Chaperones for Treating Gaucher Disease

Gangliosides play an important role in the organization of CD82-enriched microdomains

Glycosphingolipid synthesis inhibition limits osteoclast activation and myeloma bone disease

Targeting glycosylation as a therapeutic approach

Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase

Amphiphilic 1-Deoxynojirimycin Derivatives through Click Strategies for Chemical Chaperoning in N370S Gaucher Cells

Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone

Implications for invariant natural killer T cell ligands due to the restricted presence of isoglobotrihexosylceramide in mammals

Inhibition of Glycosphingolipid Biosynthesis: Application to Lysosomal Storage Disorders

Pharmacotherapeutic strategies using small molecules for the treatment of glycolipid lysosomal storage disorders

Rational Design and Synthesis of Highly Potent Pharmacological Chaperones for Treatment of N370S Mutant Gaucher Disease

Adduction of Cholesterol 5,6-Secosterol Aldehyde to Membrane-Bound Myelin Basic Protein Exposes an Immunodominant Epitope

Scalable Syntheses of Both Enantiomers of DNJNAc and DGJNAc from Glucuronolactone: The Effect of N-Alkylation on Hexosaminidase Inhibition

Glucosylated free oligosaccharides are biomarkers of endoplasmic- reticulum alpha-glucosidase inhibition

Glycoprotein misfolding in the endoplasmic reticulum: identification of released oligosaccharides reveals a second ER-associated degradation pathway for Golgi-retrieved proteins

Development of a Single Column Method for the Separation of Lipid- and Protein-Derived Oligosaccharides

Gaucher disease

Inhibition of α-glucosidase activity by N-deoxynojirimycin analogs in several insect phloem sap feeders

Analysis of fluorescently labeled glycosphingolipid-derived oligosaccharides following ceramide glycanase digestion and anthranilic acid labeling

Selection of the biological activity of DNJ neoglycoconjugates through click length variation of the side chain

Activation state and intracellular trafficking contribute to the repertoire of endogenous glycosphingolipids presented by CD1d

A Novel Iminosugar UV-12 with Activity against the Diverse Viruses Influenza and Dengue (Novel Iminosugar Antiviral for Influenza and Dengue)

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