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HIV capsid is a tractable target for small molecule therapeutic intervention

PLoS pathogens, 2010-12, Vol.6 (12), p.e1001220

2010

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A quantitative assay for HIV DNA integration in vivo

Nature medicine, 2001-05, Vol.7 (5), p.631-634

2001

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Structural and functional insights into the HIV-1 maturation inhibitor binding pocket

PLoS pathogens, 2012-11, Vol.8 (11), p.e1002997-e1002997

2012

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Modified mRNA Vaccines Protect against Zika Virus Infection

Cell, 2017-03, Vol.168 (6), p.1114-1125.e10

2017

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Human Immunodeficiency Virus cDNA Metabolism: Notable Stability of Two-Long Terminal Repeat Circles

Journal of Virology, 2002-04, Vol.76 (8), p.3739-3747

2002

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New Small-Molecule Inhibitor Class Targeting Human Immunodeficiency Virus Type 1 Virion Maturation

Antimicrobial Agents and Chemotherapy, 2009-12, Vol.53 (12), p.5080-5087

2009

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Use of Site‐Directed Cysteine and Disulfide Chemistry to Probe Protein Structure and Dynamics: Applications to Soluble and Transmembrane Receptors of Bacterial Chemotaxis

Methods in Enzymology, 2007, Vol.423, p.25-51

2007

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Modified mRNA Vaccines Protect against Zika Virus Infection

Cell, 2017-03, Vol.169 (1), p.176-176

2017

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A Low-Molecular-Weight Entry Inhibitor of both CCR5- and CXCR4-Tropic Strains of Human Immunodeficiency Virus Type 1 Targets a Novel Site on gp41

Journal of Virology, 2010-07, Vol.84 (14), p.7288-7299

2010

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THE TWO-COMPONENT SIGNALING PATHWAY OF BACTERIAL CHEMOTAXIS: A Molecular View of Signal Transduction by Receptors, Kinases, and Adaptation Enzymes

Annual review of cell and developmental biology, 1997-01, Vol.13 (1), p.457-512

1997

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Disease-modifying therapeutic concepts for HIV in the era of highly active antiretroviral therapy

Journal of acquired immune deficiency syndromes (1999), 2011-11, Vol.58 (3), p.297-303

2011

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Compensatory substitutions in the HIV-1 capsid reduce the fitness cost associated with resistance to a capsid-targeting small-molecule inhibitor

Journal of virology, 2015-01, Vol.89 (1), p.208-219

2015

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Identification and Characterization of UK-201844, a Novel Inhibitor That Interferes with Human Immunodeficiency Virus Type 1 gp160 Processing

Antimicrobial Agents and Chemotherapy, 2007-10, Vol.51 (10), p.3554-3561

2007

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Pharmacokinetic and Pharmacodynamic Evaluation of AZD5847 in a Mouse Model of Tuberculosis

Antimicrobial agents and chemotherapy, 2014-07, Vol.58 (7), p.4185-4190

2014

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Role of the non-homologous DNA end joining pathway in the early steps of retroviral infection

The EMBO journal, 2001-06, Vol.20 (12), p.3272-3281

2001

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Human immunodeficiency virus type 1 integrase: arrangement of protein domains in active cDNA complexes

The EMBO journal, 2001-07, Vol.20 (13), p.3565-3576

2001

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Design and Synthesis of Novel N-Hydroxy-Dihydronaphthyridinones as Potent and Orally Bioavailable HIV-1 Integrase Inhibitors

Journal of medicinal chemistry, 2011-05, Vol.54 (9), p.3393-3417

2011

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2nd International Conference on Progressive Multifocal Leukoencephalopathy (PML) 2015: JCV virology, progressive multifocal leukoencephalopathy pathogenesis, diagnosis and risk stratification, and new approaches to prevention and treatment

Journal of neurovirology, 2015-12, Vol.21 (6), p.702-705

2015

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Azaindole Hydroxamic Acids are Potent HIV-1 Integrase Inhibitors

Journal of medicinal chemistry, 2009-11, Vol.52 (22), p.7211-7219

2009

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Effects of Protein Stabilizing Agents on Thermal Backbone Motions: A Disulfide Trapping Study

Biochemistry (Easton), 1996-08, Vol.35 (33), p.10595-10600

1996

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The Mobility of an HIV-1 Integrase Active Site Loop Is Correlated with Catalytic Activity

Biochemistry (Easton), 1999-07, Vol.38 (28), p.8892-8898

1999

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Cell-based and biochemical screening approaches for the discovery of novel HIV-1 inhibitors

Antiviral research, 2005-09, Vol.67 (3), p.121-140

2005

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Azaindole N-methyl hydroxamic acids as HIV-1 integrase inhibitors-II. The impact of physicochemical properties on ADME and PK

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (24), p.7429-7434

2010

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Cysteine and Disulfide Scanning Reveals Two Amphiphilic Helices in the Linker Region of the Aspartate Chemoreceptor

Biochemistry (Easton), 1998-07, Vol.37 (30), p.10746-10756

1998

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Discovery of an HIV integrase inhibitor with an excellent resistance profile

MedChemComm, 2013, Vol.4 (4), p.709

2013

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HIV capsid is a tractable target for small molecule therapeutic intervention

A quantitative assay for HIV DNA integration in vivo

Structural and functional insights into the HIV-1 maturation inhibitor binding pocket

Modified mRNA Vaccines Protect against Zika Virus Infection

Human Immunodeficiency Virus cDNA Metabolism: Notable Stability of Two-Long Terminal Repeat Circles

New Small-Molecule Inhibitor Class Targeting Human Immunodeficiency Virus Type 1 Virion Maturation

Use of Site‐Directed Cysteine and Disulfide Chemistry to Probe Protein Structure and Dynamics: Applications to Soluble and Transmembrane Receptors of Bacterial Chemotaxis

Modified mRNA Vaccines Protect against Zika Virus Infection

A Low-Molecular-Weight Entry Inhibitor of both CCR5- and CXCR4-Tropic Strains of Human Immunodeficiency Virus Type 1 Targets a Novel Site on gp41

THE TWO-COMPONENT SIGNALING PATHWAY OF BACTERIAL CHEMOTAXIS: A Molecular View of Signal Transduction by Receptors, Kinases, and Adaptation Enzymes

Disease-modifying therapeutic concepts for HIV in the era of highly active antiretroviral therapy

Compensatory substitutions in the HIV-1 capsid reduce the fitness cost associated with resistance to a capsid-targeting small-molecule inhibitor

Identification and Characterization of UK-201844, a Novel Inhibitor That Interferes with Human Immunodeficiency Virus Type 1 gp160 Processing

Pharmacokinetic and Pharmacodynamic Evaluation of AZD5847 in a Mouse Model of Tuberculosis

Role of the non-homologous DNA end joining pathway in the early steps of retroviral infection

Human immunodeficiency virus type 1 integrase: arrangement of protein domains in active cDNA complexes

Design and Synthesis of Novel N-Hydroxy-Dihydronaphthyridinones as Potent and Orally Bioavailable HIV-1 Integrase Inhibitors

2nd International Conference on Progressive Multifocal Leukoencephalopathy (PML) 2015: JCV virology, progressive multifocal leukoencephalopathy pathogenesis, diagnosis and risk stratification, and new approaches to prevention and treatment

Azaindole Hydroxamic Acids are Potent HIV-1 Integrase Inhibitors

Effects of Protein Stabilizing Agents on Thermal Backbone Motions: A Disulfide Trapping Study

The Mobility of an HIV-1 Integrase Active Site Loop Is Correlated with Catalytic Activity

Cell-based and biochemical screening approaches for the discovery of novel HIV-1 inhibitors

Azaindole N-methyl hydroxamic acids as HIV-1 integrase inhibitors-II. The impact of physicochemical properties on ADME and PK

Cysteine and Disulfide Scanning Reveals Two Amphiphilic Helices in the Linker Region of the Aspartate Chemoreceptor

Discovery of an HIV integrase inhibitor with an excellent resistance profile

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