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Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

European journal of pharmacology, 2010-12, Vol.649 (1), p.328-335

2010

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Metopimazine is primarily metabolized by a liver amidase in humans

Pharmacology research & perspectives, 2022-02, Vol.10 (1), p.e00903-n/a

2022

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Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation

The Journal of pharmacology and experimental therapeutics, 2013-01, Vol.344 (1), p.196

2013

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Clarification of Linaclotide Pharmacology Presented in a Recent Clinical Study of Plecanatide

Digestive diseases and sciences, 2014-05, Vol.59 (5), p.1066-1067

2014

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Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract

Life sciences (1973), 2010-05, Vol.86 (19), p.760-765

2010

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Escherichia coli LipA Is a Lipoyl Synthase: In Vitro Biosynthesis of Lipoylated Pyruvate Dehydrogenase Complex from Octanoyl-Acyl Carrier Protein

Biochemistry (Easton), 2000-12, Vol.39 (49), p.15166-15178

2000

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Linaclotide pharmacodynamics

P&T (Lawrenceville, N.J.), 2013-07, Vol.38 (7), p.397-397

2013

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Circular Dichroism and Magnetic Circular Dichroism Spectroscopic Studies of the Non-Heme Ferrous Active Site in Clavaminate Synthase and Its Interaction with α-Ketoglutarate Cosubstrate

Journal of the American Chemical Society, 1998-02, Vol.120 (4), p.743-753

1998

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Metabolism and disposition of MM‐433593, a selective FAAH‐1 inhibitor, in monkeys

Pharmacology research & perspectives, 2014-10, Vol.2 (5), p.e00059-n/a

2014

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A single monomeric iron center in clavaminate synthase catalyzes three nonsuccessive oxidative transformations

Bioorganic & medicinal chemistry, 1996-07, Vol.4 (7), p.1059-1064

1996

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Lipoic Acid Biosynthesis: LipA Is an Iron−Sulfur Protein

Journal of the American Chemical Society, 1999-05, Vol.121 (19), p.4706-4707

1999

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Abstract CT146: RGX-104, a first-in-class immunotherapy targeting the liver-X receptor (LXR): Initial results from the phase 1b RGX-104 plus docetaxel combination dose escalation cohorts

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.CT146-CT146

2020

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Site-Directed Mutagenesis and Biochemical Analysis of the Endogenous Ligands in the Ferrous Active Site of Clavaminate Synthase. The His-3 Variant of the 2-His-1-Carboxylate Model

Biochemistry (Easton), 2000-07, Vol.39 (29), p.8666-8673

2000

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Probable Role of Clavaminic Acid as the Terminal Intermediate in the Common Pathway to Clavulanic Acid and the Antipodal Clavam Metabolites

Journal of the American Chemical Society, 1997-03, Vol.119 (10), p.2348-2355

1997

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A Strategy for Identifying Novel, Mechanistically Unique Inhibitors of Topoisomerase I

Journal of natural products (Washington, D.C.), 1992-04, Vol.55 (4), p.401-413

1992

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Expression and Purification of Two Isozymes of Clavaminate Synthase and Initial Characterization of the Iron Binding Site

The Journal of biological chemistry, 1995-03, Vol.270 (9), p.4262-4269

1995

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Effects of Single Dose Administration of MD-1100 on Safety, Tolerability, Exposure, and Stool Consistency in Healthy Subjects: 894

The American journal of gastroenterology, 2005-09, Vol.100, p.S328

2005

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Irreversible trapping of the DNA-topoisomerase I covalent complex. Affinity labeling of the camptothecin binding site

The Journal of biological chemistry, 1990-11, Vol.265 (31), p.19287-19295

1990

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Expression and Purification of Two Isozymes of Clavaminate Synthase and Initial Characterization of the Iron Binding Site: GENERAL ERROR ANALYSIS IN POLYMERASE CHAIN REACTION AMPLIFICATION

The Journal of biological chemistry, 1995-03, Vol.270 (9), p.4262-4269

1995

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Identification, cloning, sequencing, and overexpression of the gene encoding proclavaminate amidino hydrolase and characterization of protein function in clavulanic acid biosynthesis

Journal of Bacteriology, 1995-07, Vol.177 (13), p.3714-3720

1995

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nth Root Groups

Mathematics magazine, 1976-05, Vol.49 (3), p.140-141

1976

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n th Root Groups

Mathematics magazine, 1976-05, Vol.49 (3), p.140-141

1976

Volltextzugriff (PDF)

nth Root Groups

Mathematics magazine, 1976-05, Vol.49 (3), p.140-141

1976

Volltextzugriff (PDF)

Rationale for a Permanent Seismic Network in the U.S. Central Plains Utilizing USArray

Eos (Washington, D.C.), 2008-02, Vol.89 (9), p.85-85

2008

Volltextzugriff (PDF)

DNA barcodes for rapid, whole genome, single-molecule analyses

Nucleic acids research, 2019-07, Vol.47 (12), p.e68

2019

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Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

Metopimazine is primarily metabolized by a liver amidase in humans

Pharmacologic properties, metabolism, and disposition of linaclotide, a novel therapeutic peptide approved for the treatment of irritable bowel syndrome with constipation and chronic idiopathic constipation

Clarification of Linaclotide Pharmacology Presented in a Recent Clinical Study of Plecanatide

Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract

Escherichia coli LipA Is a Lipoyl Synthase: In Vitro Biosynthesis of Lipoylated Pyruvate Dehydrogenase Complex from Octanoyl-Acyl Carrier Protein

Linaclotide pharmacodynamics

Circular Dichroism and Magnetic Circular Dichroism Spectroscopic Studies of the Non-Heme Ferrous Active Site in Clavaminate Synthase and Its Interaction with α-Ketoglutarate Cosubstrate

Metabolism and disposition of MM‐433593, a selective FAAH‐1 inhibitor, in monkeys

A single monomeric iron center in clavaminate synthase catalyzes three nonsuccessive oxidative transformations

Lipoic Acid Biosynthesis: LipA Is an Iron−Sulfur Protein

Abstract CT146: RGX-104, a first-in-class immunotherapy targeting the liver-X receptor (LXR): Initial results from the phase 1b RGX-104 plus docetaxel combination dose escalation cohorts

Site-Directed Mutagenesis and Biochemical Analysis of the Endogenous Ligands in the Ferrous Active Site of Clavaminate Synthase. The His-3 Variant of the 2-His-1-Carboxylate Model

Probable Role of Clavaminic Acid as the Terminal Intermediate in the Common Pathway to Clavulanic Acid and the Antipodal Clavam Metabolites

A Strategy for Identifying Novel, Mechanistically Unique Inhibitors of Topoisomerase I

Expression and Purification of Two Isozymes of Clavaminate Synthase and Initial Characterization of the Iron Binding Site

Effects of Single Dose Administration of MD-1100 on Safety, Tolerability, Exposure, and Stool Consistency in Healthy Subjects: 894

Irreversible trapping of the DNA-topoisomerase I covalent complex. Affinity labeling of the camptothecin binding site

Expression and Purification of Two Isozymes of Clavaminate Synthase and Initial Characterization of the Iron Binding Site: GENERAL ERROR ANALYSIS IN POLYMERASE CHAIN REACTION AMPLIFICATION

Identification, cloning, sequencing, and overexpression of the gene encoding proclavaminate amidino hydrolase and characterization of protein function in clavulanic acid biosynthesis

nth Root Groups

n th Root Groups

nth Root Groups

Rationale for a Permanent Seismic Network in the U.S. Central Plains Utilizing USArray

DNA barcodes for rapid, whole genome, single-molecule analyses

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