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Predicting drug absorption: how nature made it a difficult problem

The Journal of pharmacology and experimental therapeutics, 2002-12, Vol.303 (3), p.889-895

2002

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Physicochemical Determinants of Passive Membrane Permeability: Role of Solute Hydrogen-Bonding Potential and Volume

Journal of medicinal chemistry, 2001-10, Vol.44 (22), p.3721-3729

2001

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Evaluation of a basic physiologically based pharmacokinetic model for simulating the first-time-in-animal study

European journal of pharmaceutical sciences, 2007-07, Vol.31 (3), p.190-201

2007

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Quantitative and Mechanistic Assessment of Model Lipophilic Drugs in Micellar Solutions in the Transport Kinetics Across MDR1-MDCK Cell Monolayers

Journal of pharmaceutical sciences, 2016-02, Vol.105 (2), p.904-914

2016

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A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P‐glycoprotein activity in vitro

Journal of pharmaceutical sciences, 2002-09, Vol.91 (9), p.1991-2002

2002

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Automated Analysis of Polyethylene Glycol-Induced Inhibition of P-Glycoprotein Activity In Vitro

Journal of pharmaceutical sciences, 2003-01, Vol.92 (1), p.21-26

2003

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Influence of Molecular Flexibility and Polar Surface Area Metrics on Oral Bioavailability in the Rat

Journal of medicinal chemistry, 2004-11, Vol.47 (24), p.6104-6107

2004

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Solubility and permeability measurement and applications in drug discovery

Combinatorial chemistry & high throughput screening, 2010-02, Vol.13 (2), p.101-111

2010

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Summary workshop report: Biopharmaceutics classification system—implementation challenges and extension opportunities

Journal of pharmaceutical sciences, 2004-06, Vol.93 (6), p.1375-1381

2004

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Mechanistic Roles of Neutral Surfactants on Concurrent Polarized and Passive Membrane Transport of a Model Peptide in Caco-2 Cells

Journal of pharmaceutical sciences, 1997-07, Vol.86 (7), p.813-821

1997

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Predicting oral absorption of drugs: A case study with a novel class of antimicrobial agents

Pharmaceutical research, 2003-08, Vol.20 (8), p.1149-1155

2003

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How Structural Features Influence the Biomembrane Permeability of Peptides

Journal of pharmaceutical sciences, 1996-12, Vol.85 (12), p.1336-1340

1996

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Quantitative Approaches To Delineate Paracellular Diffusion in Cultured Epithelial Cell Monolayers

Journal of pharmaceutical sciences, 1994-11, Vol.83 (11), p.1529-1536

1994

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Passive Diffusion of Weak Organic Electrolytes across Caco‐2 Cell Monolayers: Uncoupling the Contributions of Hydrodynamic, Transcellular, and Paracellular Barriers

Journal of pharmaceutical sciences, 1995-10, Vol.84 (10), p.1197-1204

1995

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The influence of peptide structure on transport across caco-2 cells. II: Peptide bond modification which results in improved permeability

Pharmaceutical research, 1992-03, Vol.9 (3), p.435-439

1992

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Mechanism, structure-activity studies, and potential applications of glutathione S-transferase-catalyzed cleavage of sulfonamides

Drug metabolism and disposition, 1999-09, Vol.27 (9), p.992

1999

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Evaluation of a Physiologically‐Based Pharmacokinetic Approach for Simulating the First‐Time‐In‐Animal Study

Basic & clinical pharmacology & toxicology, 2005-03, Vol.96 (3), p.254-256

2005

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Quantitative and Mechanistic Assessment of Model Lipophilic Drugs in Micellar Solutions in the Transport Kinetics Across MDR1-MDCK Cell Monolayers: Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism

Journal of pharmaceutical sciences, 2016-02, Vol.105 (2), p.904-914

2016

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The relationship between peptide structure and transport across epithelial cell monolayers

Journal of controlled release, 1992-03, Vol.19 (1), p.87-97

1992

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Physicochemical Determinants of Passive Membrane Permeability: Role of Solute Hydrogen-Bonding Potential and Volume

Journal of medicinal chemistry, 2002-05, Vol.45 (10), p.2122-2122

2002

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In vitro permeability of peptidomimetic drugs: The role of polarized efflux pathways as additional barriers to absorption

Advanced drug delivery reviews, 1997-01, Vol.23 (1), p.143-156

1997

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An NMR study of conformations of substituted dipeptides in dodecylphosphocholine micelles: Implications for drug transport

BIOPOLYM, 2000-04, Vol.53 (5), p.396-410

2000

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Properties of native and in vitro glycosylated forms of the glucagon-like peptide-1 receptor antagonist exendin (9–39)

Metabolism, clinical and experimental, 1999-06, Vol.48 (6), p.716-724

1999

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Transport of model peptides across Ascaris suum cuticle

Molecular and biochemical parasitology, 2000-01, Vol.105 (1), p.39-49

2000

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Role of cyclohexaamylose C-3 hydroxyls in catalytic hydrolysis

Journal of the American Chemical Society, 1982-06, Vol.104 (13), p.3664-3670

1982

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Predicting drug absorption: how nature made it a difficult problem

Physicochemical Determinants of Passive Membrane Permeability: Role of Solute Hydrogen-Bonding Potential and Volume

Evaluation of a basic physiologically based pharmacokinetic model for simulating the first-time-in-animal study

Quantitative and Mechanistic Assessment of Model Lipophilic Drugs in Micellar Solutions in the Transport Kinetics Across MDR1-MDCK Cell Monolayers

A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P‐glycoprotein activity in vitro

Automated Analysis of Polyethylene Glycol-Induced Inhibition of P-Glycoprotein Activity In Vitro

Influence of Molecular Flexibility and Polar Surface Area Metrics on Oral Bioavailability in the Rat

Solubility and permeability measurement and applications in drug discovery

Summary workshop report: Biopharmaceutics classification system—implementation challenges and extension opportunities

Mechanistic Roles of Neutral Surfactants on Concurrent Polarized and Passive Membrane Transport of a Model Peptide in Caco-2 Cells

Predicting oral absorption of drugs: A case study with a novel class of antimicrobial agents

How Structural Features Influence the Biomembrane Permeability of Peptides

Quantitative Approaches To Delineate Paracellular Diffusion in Cultured Epithelial Cell Monolayers

Passive Diffusion of Weak Organic Electrolytes across Caco‐2 Cell Monolayers: Uncoupling the Contributions of Hydrodynamic, Transcellular, and Paracellular Barriers

The influence of peptide structure on transport across caco-2 cells. II: Peptide bond modification which results in improved permeability

Mechanism, structure-activity studies, and potential applications of glutathione S-transferase-catalyzed cleavage of sulfonamides

Evaluation of a Physiologically‐Based Pharmacokinetic Approach for Simulating the First‐Time‐In‐Animal Study

Quantitative and Mechanistic Assessment of Model Lipophilic Drugs in Micellar Solutions in the Transport Kinetics Across MDR1-MDCK Cell Monolayers: Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism

The relationship between peptide structure and transport across epithelial cell monolayers

Physicochemical Determinants of Passive Membrane Permeability: Role of Solute Hydrogen-Bonding Potential and Volume

In vitro permeability of peptidomimetic drugs: The role of polarized efflux pathways as additional barriers to absorption

An NMR study of conformations of substituted dipeptides in dodecylphosphocholine micelles: Implications for drug transport

Properties of native and in vitro glycosylated forms of the glucagon-like peptide-1 receptor antagonist exendin (9–39)

Transport of model peptides across Ascaris suum cuticle

Role of cyclohexaamylose C-3 hydroxyls in catalytic hydrolysis

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