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Simultaneous modeling of metabolism, competitive and mechanism based inhibition

Drug metabolism and pharmacokinetics, 2019-01, Vol.34 (1), p.S3-S4

Burt, Howard

2019

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Physiologically‐Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug–Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations

Clinical pharmacology and therapeutics, 2020-05, Vol.107 (5), p.1082-1115

2020

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Abundance of Hepatic Transporters in Caucasians: A Meta-Analysis

Drug metabolism and disposition, 2016-10, Vol.44 (10), p.1550-1561

2016

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The nested enzyme-within-enterocyte (NEWE) turnover model for predicting dynamic drug and disease effects on the gut wall

European journal of pharmaceutical sciences, 2019-04, Vol.131, p.195-207

2019

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Prediction of time-dependent CYP3A4 drug-drug interactions: impact of enzyme degradation, parallel elimination pathways, and intestinal inhibition

Drug metabolism and disposition, 2006-01, Vol.34 (1), p.166

2006

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Progress curve mechanistic modeling approach for assessing time-dependent inhibition of CYP3A4

Drug metabolism and disposition, 2012-09, Vol.40 (9), p.1658

2012

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IC50-based approaches as an alternative method for assessment of time-dependent inhibition of CYP3A4

Xenobiotica, 2010-05, Vol.40 (5), p.331-343

2010

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Development and application of a PBPK modeling strategy to support antimalarial drug development

CPT: pharmacometrics and systems pharmacology, 2023-09, Vol.12 (9), p.1335-1346

2023

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Maximal inhibition of intestinal first-pass metabolism as a pragmatic indicator of intestinal contribution to the drug-drug interactions for CYP3A4 cleared drugs

Current drug metabolism, 2007-10, Vol.8 (7), p.685

2007

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Tipifarnib physiologically-based pharmacokinetic modeling to assess drug-drug interaction, organ impairment, and biopharmaceutics in healthy subjects and cancer patients

CPT: pharmacometrics and systems pharmacology, 2024-05

2024

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Development and verification of an endogenous PBPK model to inform hydrocortisone replacement dosing in children and adults with cortisol deficiency

European journal of pharmaceutical sciences, 2021-10, Vol.165, p.105913-105913, Article 105913

2021

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Insights into Praziquantel Metabolism and Potential Enantiomeric Cytochrome P450-Mediated Drug-Drug Interaction

Drug metabolism and disposition, 2020-06, Vol.48 (6), p.481-490

2020

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Extrapolation of praziquantel pharmacokinetics to a pediatric population: a cautionary tale

Journal of pharmacokinetics and pharmacodynamics, 2018-10, Vol.45 (5), p.747-762

2018

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Identification and Optimization of an Aminoalcohol-Carbazole Series with Antimalarial Properties

ACS medicinal chemistry letters, 2013-11, Vol.4 (11), p.1037-1041

2013

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IC 50 -based approaches as an alternative method for assessment of time-dependent inhibition of CYP3A4

Xenobiotica, 2010-05, Vol.40 (5), p.331-343

2010

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In Vitro Assessment and Prediction of Time-Dependent CYP3A4 Drug-Drug Interactions

Burt, Howard James

2008

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The Bureau of Tuberculosis, Its Work and Plans

California state journal of medicine, 1914-08, Vol.12 (8), p.324-327

Howard, B F

1914

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Rating the Efficiency of Hospitals and Institutions for the Tuberculous

California state journal of medicine, 1914-01, Vol.12 (1), p.22-24

Howard, B F

1914

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IN SILICO MODELING OF METABOLITE KINETICS

Metabolite Safety in Drug Development, 2016, p.213-237

2016

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Alsace-Lorraine

Political science quarterly, 1906-09, Vol.21 (3), p.447-474

Howard, Burt Estes

1906

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Strain Accumulation and Damage Evolution During Creep of SiCf/SiC Composites

Fracture Mechanics of Ceramics, p.221-231

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POP ZIEGLER, FIDDLER: A STUDY OF FOLKLORIC PERFORMANCE

FEINTUCH, BURT HOWARD

1975

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WISHART EXPECTATION OPERATORS AND INVARIANT DIFFERENTIAL OPERATORS

KUSHNER, HOWARD BURT

1980

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ELECTRON SCATTERING FROM AN ALIGNED DEFORMED NUCLEUS

GREENSTEIN, HOWARD BURT

1965

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La colonisation et les colonies allemandes. Par André Chéradame. (Paris: Plon-Nourrit. 1905. Pp. 485.)

The American political science review, 1907-05, Vol.1 (3), p.472-474

Howard, Burt Estes

1907

Volltextzugriff (PDF)

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Simultaneous modeling of metabolism, competitive and mechanism based inhibition

Physiologically‐Based Pharmacokinetic Models for Evaluating Membrane Transporter Mediated Drug–Drug Interactions: Current Capabilities, Case Studies, Future Opportunities, and Recommendations

Abundance of Hepatic Transporters in Caucasians: A Meta-Analysis

The nested enzyme-within-enterocyte (NEWE) turnover model for predicting dynamic drug and disease effects on the gut wall

Prediction of time-dependent CYP3A4 drug-drug interactions: impact of enzyme degradation, parallel elimination pathways, and intestinal inhibition

Progress curve mechanistic modeling approach for assessing time-dependent inhibition of CYP3A4

IC50-based approaches as an alternative method for assessment of time-dependent inhibition of CYP3A4

Development and application of a PBPK modeling strategy to support antimalarial drug development

Maximal inhibition of intestinal first-pass metabolism as a pragmatic indicator of intestinal contribution to the drug-drug interactions for CYP3A4 cleared drugs

Tipifarnib physiologically-based pharmacokinetic modeling to assess drug-drug interaction, organ impairment, and biopharmaceutics in healthy subjects and cancer patients

Development and verification of an endogenous PBPK model to inform hydrocortisone replacement dosing in children and adults with cortisol deficiency

Insights into Praziquantel Metabolism and Potential Enantiomeric Cytochrome P450-Mediated Drug-Drug Interaction

Extrapolation of praziquantel pharmacokinetics to a pediatric population: a cautionary tale

Identification and Optimization of an Aminoalcohol-Carbazole Series with Antimalarial Properties

IC 50 -based approaches as an alternative method for assessment of time-dependent inhibition of CYP3A4

In Vitro Assessment and Prediction of Time-Dependent CYP3A4 Drug-Drug Interactions

The Bureau of Tuberculosis, Its Work and Plans

Rating the Efficiency of Hospitals and Institutions for the Tuberculous

IN SILICO MODELING OF METABOLITE KINETICS

Alsace-Lorraine

Strain Accumulation and Damage Evolution During Creep of SiCf/SiC Composites

POP ZIEGLER, FIDDLER: A STUDY OF FOLKLORIC PERFORMANCE

WISHART EXPECTATION OPERATORS AND INVARIANT DIFFERENTIAL OPERATORS

ELECTRON SCATTERING FROM AN ALIGNED DEFORMED NUCLEUS

La colonisation et les colonies allemandes. Par André Chéradame. (Paris: Plon-Nourrit. 1905. Pp. 485.)

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