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From Peptides to Non-Peptide Peptidomimetics: Design and Synthesis of New Piperidine Inhibitors of Aspartic Peptidases

Organic letters, 2001-07, Vol.3 (15), p.2317-2320

2001

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P102 A small molecule selective integrin α4β7 inhibitor demonstrates efficacy in a chronic model of Inflammatory Bowel Disease

Journal of Crohn's and colitis, 2023-01, Vol.17 (Supplement_1), p.i265-i266

2023

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P037 Nonclinical pharmacokinetics and absorption, distribution, metabolism, and excretion properties of MORF-057 support its clinical development as an oral selective α4β7 integrin inhibitor

Journal of Crohn's and colitis, 2021-05, Vol.15 (Supplement_1), p.S149-S150

2021

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Solid-Phase Synthesis of Aspartic Peptidase Inhibitors: 3-Alkoxy-4-Aryl Piperidines

Organic letters, 2001-08, Vol.3 (17), p.2625-2628

2001

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DOP50 Oral α4β7 integrin inhibitor MORF-057 demonstrates exposure driven biomarker response in non-human primates

Journal of Crohn's and colitis, 2022-01, Vol.16 (Supplement_1), p.i098-i099

2022

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Designing Non-Peptide Peptidomimetics in the 21st Century: Inhibitors Targeting Conformational Ensembles

Journal of medicinal chemistry, 2002-01, Vol.45 (3), p.541-558

2002

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DOP64 Discovery of highly selective small-molecule oral inhibitors of integrin α4β7 for the treatment of inflammatory bowel diseases

Journal of Crohn's and colitis, 2020-01, Vol.14 (Supplement_1), p.S102-S103

2020

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Aspartic Protease Inhibitors: Expedient Synthesis of 2-Substituted Statines

Organic letters, 2001-08, Vol.3 (17), p.2725-2728

2001

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Discovery of nonpeptide, peptidomimetic peptidase inhibitors that target alternate enzyme active site conformations

Biopolymers, 2002, Vol.66 (2), p.115-125

2002

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Expedient Parallel Synthesis of 2-Amino-4-heteroarylpyrimidines

Organic letters, 2005-09, Vol.7 (19), p.4113-4116

2005

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tert-Butyl Carbamate at 100K

Acta crystallographica. Section C, Crystal structure communications, 1997-11, Vol.53 (11), p.IUC9700022-IUC9700022

1997

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Synthesis of a series of polar, orthogonally protected, α,α-disubstituted amino acids

Tetrahedron letters, 1997-06, Vol.38 (23), p.4013-4016

1997

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ChemInform Abstract: Synthesis of a Series of Polar, Orthogonally Protected, α,α -Disubstituted Amino Acids

ChemInform, 1997-09, Vol.28 (37), p.no-no

1997

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Novel Mps1 kinase inhibitors: From purine to pyrrolopyrimidine and quinazoline leads

Bioorganic & medicinal chemistry letters, 2013-12, Vol.23 (24), p.6829-6833

2013

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In-depth characterization of a new patient-derived xenograft model for metaplastic breast carcinoma to identify viable biologic targets and patterns of matrix evolution within rare tumor types

Clinical & translational oncology, 2022-01, Vol.24 (1), p.127-144

2022

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Strategic and Tactical Approaches to the Synthesis of 5,6-Dihydro-[1,2,4]oxadiazines

Heterocycles, 2016-12, Vol.92 (12), p.2166

2016

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Sequential Extraction and Characterization of Lignin-Derived Compounds from Thermochemically Processed Biorefinery Lignins

Energy & fuels, 2019-05, Vol.33 (5), p.4322-4330

2019

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Identification and Characterization of Acidic Mammalian Chitinase Inhibitors

Journal of medicinal chemistry, 2010-08, Vol.53 (16), p.6122-6128

2010

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2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97)

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (5), p.1677-1679

2010

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Novel benzofuran-3-one indole inhibitors of PI3 kinase-α and the mammalian target of rapamycin: Hit to lead studies

Bioorganic & medicinal chemistry letters, 2010-04, Vol.20 (8), p.2586-2590

2010

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Lead optimization of purine based orally bioavailable Mps1 (TTK) inhibitors

Bioorganic & medicinal chemistry letters, 2012-07, Vol.22 (13), p.4377-4385

2012

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N-((8-Hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2)

Bioorganic & medicinal chemistry, 2008-12, Vol.18 (24), p.6454-6457

2008

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Novel purine and pyrazolo[3,4- d]pyrimidine inhibitors of PI3 kinase-α: Hit to lead studies

Bioorganic & medicinal chemistry letters, 2010-01, Vol.20 (2), p.636-639

2010

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5-((1 H-Pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (5), p.1189-1192

2007

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From Peptides to Non-Peptide Peptidomimetics: Design and Synthesis of New Piperidine Inhibitors of Aspartic Peptidases

P102 A small molecule selective integrin α4β7 inhibitor demonstrates efficacy in a chronic model of Inflammatory Bowel Disease

P037 Nonclinical pharmacokinetics and absorption, distribution, metabolism, and excretion properties of MORF-057 support its clinical development as an oral selective α4β7 integrin inhibitor

Solid-Phase Synthesis of Aspartic Peptidase Inhibitors: 3-Alkoxy-4-Aryl Piperidines

DOP50 Oral α4β7 integrin inhibitor MORF-057 demonstrates exposure driven biomarker response in non-human primates

Designing Non-Peptide Peptidomimetics in the 21st Century: Inhibitors Targeting Conformational Ensembles

DOP64 Discovery of highly selective small-molecule oral inhibitors of integrin α4β7 for the treatment of inflammatory bowel diseases

Aspartic Protease Inhibitors: Expedient Synthesis of 2-Substituted Statines

Discovery of nonpeptide, peptidomimetic peptidase inhibitors that target alternate enzyme active site conformations

Expedient Parallel Synthesis of 2-Amino-4-heteroarylpyrimidines

tert-Butyl Carbamate at 100K

Synthesis of a series of polar, orthogonally protected, α,α-disubstituted amino acids

ChemInform Abstract: Synthesis of a Series of Polar, Orthogonally Protected, α,α -Disubstituted Amino Acids

Novel Mps1 kinase inhibitors: From purine to pyrrolopyrimidine and quinazoline leads

In-depth characterization of a new patient-derived xenograft model for metaplastic breast carcinoma to identify viable biologic targets and patterns of matrix evolution within rare tumor types

Strategic and Tactical Approaches to the Synthesis of 5,6-Dihydro-[1,2,4]oxadiazines

Sequential Extraction and Characterization of Lignin-Derived Compounds from Thermochemically Processed Biorefinery Lignins

Identification and Characterization of Acidic Mammalian Chitinase Inhibitors

2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97)

ERK5 Is Required for Tumor Growth and Maintenance Through Regulation of the Extracellular Matrix in Triple Negative Breast Cancer

Novel benzofuran-3-one indole inhibitors of PI3 kinase-α and the mammalian target of rapamycin: Hit to lead studies

Lead optimization of purine based orally bioavailable Mps1 (TTK) inhibitors

N-((8-Hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2)

Novel purine and pyrazolo[3,4- d]pyrimidine inhibitors of PI3 kinase-α: Hit to lead studies

5-((1 H-Pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5

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