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Recent advances in botulinum neurotoxin inhibitor development

Current topics in medicinal chemistry, 2014-01, Vol.14 (18), p.2044-2061

2014

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Next-Generation Cell-Active Inhibitors of the Undrugged Oncogenic PTP4A3 Phosphatase

The Journal of pharmacology and experimental therapeutics, 2019-12, Vol.371 (3), p.652-662

2019

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Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity

Bioorganic & medicinal chemistry letters, 2013-08, Vol.23 (16), p.4669-4673

2013

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Inhibition of Metalloprotease Botulinum Serotype A from a Pseudo-peptide Binding Mode to a Small Molecule That Is Active in Primary Neurons

The Journal of biological chemistry, 2007-02, Vol.282 (7), p.5004-5014

2007

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The synthesis of 2,5-bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease

European journal of medicinal chemistry, 2012-07, Vol.53, p.374-379

2012

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Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays

PloS one, 2015-06, Vol.10 (6), p.e0129264

2015

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Comparison of the Activities of the Truncated Halichondrin B Analog NSC 707389 (E7389) with Those of the Parent Compound and a Proposed Binding Site on Tubulin

Molecular pharmacology, 2006-12, Vol.70 (6), p.1866-1875

2006

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Methyl Scanning and Revised Binding Mode of 2‑Pralidoxime, an Antidote for Nerve Agent Poisoning

ACS medicinal chemistry letters, 2020-10, Vol.11 (10), p.1893-1898

2020

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Small molecule inhibitors as countermeasures for botulinum neurotoxin intoxication

Molecules, 2010-12, Vol.16 (1), p.202-220

2010

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Small molecule targeting of PTPs in cancer

The international journal of biochemistry & cell biology, 2018-03, Vol.96, p.171-181

2018

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Iterative structure-based peptide-like inhibitor design against the botulinum neurotoxin serotype A

PloS one, 2010-06, Vol.5 (6), p.e11378

2010

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Structural Basis for the Potent Antisickling Effect of a Novel Class of Five-Membered Heterocyclic Aldehydic Compounds

Journal of medicinal chemistry, 2004-09, Vol.47 (19), p.4665-4676

2004

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Tapping the therapeutic potential of protein tyrosine phosphatase 4A with small molecule inhibitors

Bioorganic & medicinal chemistry letters, 2019-08, Vol.29 (16), p.2008-2015

2019

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Three‐Dimensional Database Mining Identifies a Unique Chemotype that Unites Structurally Diverse Botulinum Neurotoxin Serotype A Inhibitors in a Three‐Zone Pharmacophore

ChemMedChem, 2008-12, Vol.3 (12), p.1905-1912

2008

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In-flow photooxygenation of aminothienopyridinones generates iminopyridinedione PTP4A3 phosphatase inhibitors

Organic & biomolecular chemistry, 2019-02, Vol.17 (9), p.2448-2466

2019

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Specific RITA Modification Produces Hyperselective Cytotoxicity While Maintaining In Vivo Antitumor Efficacy

Molecular cancer therapeutics, 2019-10, Vol.18 (10), p.1765-1774

2019

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Do Zebrafish Obey Lipinski Rules?

ACS medicinal chemistry letters, 2019-06, Vol.10 (6), p.1002-1006

2019

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A Common Pharmacophore for a Diverse Set of Colchicine Site Inhibitors Using a Structure-Based Approach

Journal of medicinal chemistry, 2005-09, Vol.48 (19), p.6107-6116

2005

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Synthesis of Heterocyclic Triads by Pd-Catalyzed Cross-Couplings and Evaluation of Their Cell-Specific Toxicity Profile

Organic letters, 2014-04, Vol.16 (7), p.2034-2037

2014

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A limited structural modification results in a significantly more efficacious diazachrysene-based filovirus inhibitor

Viruses, 2012-08, Vol.4 (8), p.1279-1288

2012

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Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor

Oncotarget, 2018-02, Vol.9 (9), p.8223-8240

2018

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New 9-aminoacridine derivatives as inhibitors of Botulinum neurotoxins and P. falciparum malaria

Journal of the Serbian Chemical Society, 2013-01, Vol.78 (12), p.1847-1864

2013

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Post-intoxication inhibition of botulinum neurotoxin serotype A within neurons by small-molecule, non-peptidic inhibitors

Toxins, 2011-03, Vol.3 (3), p.207-217

2011

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A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site

Organic & biomolecular chemistry, 2017-05, Vol.15 (19), p.4096-4114

2017

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The evolving field of biodefence: therapeutic developments and diagnostics

Nature reviews. Drug discovery, 2005-04, Vol.4 (4), p.281-296

2005

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Recent advances in botulinum neurotoxin inhibitor development

Next-Generation Cell-Active Inhibitors of the Undrugged Oncogenic PTP4A3 Phosphatase

Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity

Inhibition of Metalloprotease Botulinum Serotype A from a Pseudo-peptide Binding Mode to a Small Molecule That Is Active in Primary Neurons

The synthesis of 2,5-bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease

Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays

Comparison of the Activities of the Truncated Halichondrin B Analog NSC 707389 (E7389) with Those of the Parent Compound and a Proposed Binding Site on Tubulin

Methyl Scanning and Revised Binding Mode of 2‑Pralidoxime, an Antidote for Nerve Agent Poisoning

Small molecule inhibitors as countermeasures for botulinum neurotoxin intoxication

Small molecule targeting of PTPs in cancer

Iterative structure-based peptide-like inhibitor design against the botulinum neurotoxin serotype A

Structural Basis for the Potent Antisickling Effect of a Novel Class of Five-Membered Heterocyclic Aldehydic Compounds

Tapping the therapeutic potential of protein tyrosine phosphatase 4A with small molecule inhibitors

Three‐Dimensional Database Mining Identifies a Unique Chemotype that Unites Structurally Diverse Botulinum Neurotoxin Serotype A Inhibitors in a Three‐Zone Pharmacophore

In-flow photooxygenation of aminothienopyridinones generates iminopyridinedione PTP4A3 phosphatase inhibitors

Specific RITA Modification Produces Hyperselective Cytotoxicity While Maintaining In Vivo Antitumor Efficacy

Do Zebrafish Obey Lipinski Rules?

A Common Pharmacophore for a Diverse Set of Colchicine Site Inhibitors Using a Structure-Based Approach

Synthesis of Heterocyclic Triads by Pd-Catalyzed Cross-Couplings and Evaluation of Their Cell-Specific Toxicity Profile

A limited structural modification results in a significantly more efficacious diazachrysene-based filovirus inhibitor

Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor

New 9-aminoacridine derivatives as inhibitors of Botulinum neurotoxins and P. falciparum malaria

Post-intoxication inhibition of botulinum neurotoxin serotype A within neurons by small-molecule, non-peptidic inhibitors

A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site

The evolving field of biodefence: therapeutic developments and diagnostics

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