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An Overview of in vitro Methods to Study Microglia

Frontiers in cellular neuroscience, 2018-08, Vol.12, p.242-242

2018

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VISTA expression by microglia decreases during inflammation and is differentially regulated in CNS diseases

Glia, 2018-12, Vol.66 (12), p.2645-2658

2018

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Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo

Cell reports (Cambridge), 2018-07, Vol.24 (5), p.1203-1217.e6

2018

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Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors

Cancer discovery, 2022-05, Vol.12 (5), p.1248-1265

2022

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Inflammasome-induced IL-1β secretion in microglia is characterized by delayed kinetics and is only partially dependent on inflammatory caspases

The Journal of neuroscience, 2015-01, Vol.35 (2), p.678-687

2015

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Transcriptome analysis reveals the contribution of oligodendrocyte and radial glia‐derived cues for maintenance of microglia identity

Glia, 2022-04, Vol.70 (4), p.728-747

2022

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An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation

Oncoimmunology, 2022, Vol.11 (1), p.2030135-2030135

2022

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DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity

Journal for immunotherapy of cancer, 2022-06, Vol.10 (6), p.e004322

2022

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Transcriptome and proteome profiling of neural stem cells from the human subventricular zone in Parkinson's disease

Acta neuropathologica communications, 2019-06, Vol.7 (1), p.84-84, Article 84

2019

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Systematic study of tissue factor expression in solid tumors

Cancer reports, 2023-02, Vol.6 (2), p.e1699-n/a

2023

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TLR-Induced IL-12 and CCL2 Production by Myeloid Cells Is Dependent on Adenosine A3 Receptor–Mediated Signaling

The Journal of immunology (1950), 2019-04, Vol.202 (8), p.2421-2430

2019

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Mechanistic and pharmacodynamic studies of DuoBody-CD3x5T4 in preclinical tumor models

Life science alliance, 2022-11, Vol.5 (11), p.e202201481

2022

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Alternative methods for the use of non-human primates in biomedical research

ALTEX, alternatives to animal experimentation, 2014, Vol.31 (4), p.520-529

2014

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561 DuoBody®-PD-L1×4–1BB (GEN1046) induces superior immune-cell activation, cytokine production and cytotoxicity by combining PD-L1 blockade with conditional 4–1BB co-stimulation

Journal for immunotherapy of cancer, 2020-11, Vol.8 (Suppl 3), p.A338-A339

2020

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ATP-induced IL-1β secretion is selectively impaired in microglia as compared to hematopoietic macrophages

Glia, 2016-12, Vol.64 (12), p.2231-2246

2016

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Expression of IL-1β in rhesus EAE and MS lesions is mainly induced in the CNS itself

Journal of neuroinflammation, 2016-06, Vol.13 (1), p.138-138, Article 138

2016

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Abstract 1846: DuoBody-CD40×4-1BB (GEN1042) induces dendritic-cell maturation and enhances T-cell activation and effector functions in vitro by conditional CD40 and 4-1BB agonist activity

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1846-1846

2021

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ATP-induced IL-1[beta] secretion is selectively impaired in microglia as compared to hematopoietic macrophages

Glia, 2016-12, Vol.64 (12), p.2231

2016

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ATP-induced IL-1β secretion is selectively impaired in microglia as compared to hematopoietic macrophages: Microglial Adaptation of Innate Immune Responses

Glia, 2016-12, Vol.64 (12), p.2231-2246

2016

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1208 DuoBody®-PD-L1x4–1BB (GEN1046) reverses T-cell exhaustion in vitro

Journal for immunotherapy of cancer, 2022-11, Vol.10 (Suppl 2), p.A1253-A1253

2022

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Abstract 3283: GEN1046 (DuoBody®-PD-L1x4-1BB) in combination with PD-1 blockade potentiates anti-tumor immunity

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.3283-3283

2023

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Transcriptome and proteome profiling of neural stem cells from the human subventricular zone in Parkinson’s disease

Acta neuropathologica communications, 2019-08, Vol.7

2019

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Expression of IL-1[beta] in rhesus EAE and MS lesions is mainly induced in the CNS itself

Journal of neuroinflammation, 2016-06, Vol.13 (1)

2016

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Inflammasome-mediated activation of microglia differs importantly from that of hematopoietic macrophages

Journal of neuroimmunology, 2014-01, Vol.275 (1), p.81-81

2014

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704 Preclinical mechanism of action and pharmacodynamic biomarker studies of DuoBody®-CD3x5T4 in vitro and in vivo in solid cancer models

Journal for immunotherapy of cancer, 2020-11, Vol.8 (Suppl 3), p.A746-A746

2020

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An Overview of in vitro Methods to Study Microglia

VISTA expression by microglia decreases during inflammation and is differentially regulated in CNS diseases

Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo

Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors

Inflammasome-induced IL-1β secretion in microglia is characterized by delayed kinetics and is only partially dependent on inflammatory caspases

Transcriptome analysis reveals the contribution of oligodendrocyte and radial glia‐derived cues for maintenance of microglia identity

An Fc-inert PD-L1×4-1BB bispecific antibody mediates potent anti-tumor immunity in mice by combining checkpoint inhibition and conditional 4-1BB co-stimulation

DuoBody-CD40x4-1BB induces dendritic-cell maturation and enhances T-cell activation through conditional CD40 and 4-1BB agonist activity

Transcriptome and proteome profiling of neural stem cells from the human subventricular zone in Parkinson's disease

Systematic study of tissue factor expression in solid tumors

TLR-Induced IL-12 and CCL2 Production by Myeloid Cells Is Dependent on Adenosine A3 Receptor–Mediated Signaling

Mechanistic and pharmacodynamic studies of DuoBody-CD3x5T4 in preclinical tumor models

Alternative methods for the use of non-human primates in biomedical research

561 DuoBody®-PD-L1×4–1BB (GEN1046) induces superior immune-cell activation, cytokine production and cytotoxicity by combining PD-L1 blockade with conditional 4–1BB co-stimulation

ATP-induced IL-1β secretion is selectively impaired in microglia as compared to hematopoietic macrophages

Expression of IL-1β in rhesus EAE and MS lesions is mainly induced in the CNS itself

Abstract 1846: DuoBody-CD40×4-1BB (GEN1042) induces dendritic-cell maturation and enhances T-cell activation and effector functions in vitro by conditional CD40 and 4-1BB agonist activity

ATP-induced IL-1[beta] secretion is selectively impaired in microglia as compared to hematopoietic macrophages

ATP-induced IL-1β secretion is selectively impaired in microglia as compared to hematopoietic macrophages: Microglial Adaptation of Innate Immune Responses

1208 DuoBody®-PD-L1x4–1BB (GEN1046) reverses T-cell exhaustion in vitro

Abstract 3283: GEN1046 (DuoBody®-PD-L1x4-1BB) in combination with PD-1 blockade potentiates anti-tumor immunity

Transcriptome and proteome profiling of neural stem cells from the human subventricular zone in Parkinson’s disease

Expression of IL-1[beta] in rhesus EAE and MS lesions is mainly induced in the CNS itself

Inflammasome-mediated activation of microglia differs importantly from that of hematopoietic macrophages

704 Preclinical mechanism of action and pharmacodynamic biomarker studies of DuoBody®-CD3x5T4 in vitro and in vivo in solid cancer models

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