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An in vitro study of liposomal curcumin: Stability, toxicity and biological activity in human lymphocytes and Epstein-Barr virus-transformed human B-cells

International journal of pharmaceutics, 2009-01, Vol.366 (1), p.133-139

2009

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The Novel Silatecan 7-tert-Butyldimethylsilyl-10-hydroxycamptothecin Displays High Lipophilicity, Improved Human Blood Stability, and Potent Anticancer Activity

Journal of medicinal chemistry, 2000-10, Vol.43 (21), p.3970-3980

2000

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Reduced Albumin Binding Promotes the Stability and Activity of Topotecan in Human Blood

Biochemistry (Easton), 1995-10, Vol.34 (42), p.13722-13728

1995

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The acidic microclimate in poly(lactide-co-glycolide) microspheres stabilizes camptothecins

Pharmaceutical research, 1999-02, Vol.16 (2), p.241-248

1999

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The Novel Highly Lipophilic Topoisomerase I Inhibitor DB67 Is Effective in the Treatment of Liver Metastases of Murine CT-26 Colon Carcinoma

Neoplasia (New York, N.Y.), 2004-09, Vol.6 (5), p.457-467

2004

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Differential Interactions of Camptothecin Lactone and Carboxylate Forms with Human Blood Components

Biochemistry (Easton), 1994-08, Vol.33 (34), p.10325-10336

1994

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Stabilization of 10-hydroxycamptothecin in poly(lactide-co-glycolide) microsphere delivery vehicles

Pharmaceutical research, 1997-10, Vol.14 (10), p.1406-1414

1997

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Marked Interspecies Variations Concerning the Interactions of Camptothecin with Serum Albumins: A Frequency-Domain Fluorescence Spectroscopic Study

Biochemistry (Easton), 1994-10, Vol.33 (42), p.12540-12545

1994

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Novel A,B,E-Ring-Modified Camptothecins Displaying High Lipophilicity and Markedly Improved Human Blood Stabilities

Journal of medicinal chemistry, 1999-08, Vol.42 (16), p.3018-3022

1999

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Potent topoisomerase I inhibition by novel silatecans eliminates glioma proliferation in vitro and in vivo

Cancer research (Chicago, Ill.), 1999-10, Vol.59 (19), p.4898-4905

1999

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DNA base modifications induced in isolated human chromatin by NADH dehydrogenase-catalyzed reduction of doxorubicin

Biochemistry (Easton), 1992-04, Vol.31 (13), p.3500-3506

1992

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A Versatile Prodrug Approach for Liposomal Core-Loading of Water-Insoluble Camptothecin Anticancer Drugs

Journal of the American Chemical Society, 2002-07, Vol.124 (26), p.7650-7651

2002

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DNA Interactions of Two Clinical Camptothecin Drugs Stabilize Their Active Lactone Forms

Journal of the American Chemical Society, 1998-04, Vol.120 (12), p.2979-2980

1998

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Plasma and tissue disposition of non-liposomal DB-67 and liposomal DB-67 in C.B-17 SCID mice

Investigational new drugs, 2008-10, Vol.26 (5), p.399-406

2008

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Analysis of human topoisomerase I inhibition and interaction with the cleavage site +1 deoxyguanosine, via in vitro experiments and molecular modeling studies

Bioorganic & medicinal chemistry, 2004-10, Vol.12 (19), p.5225-5235

2004

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Lipid bilayer partitioning and stability of camptothecin drugs

Biochemistry (Easton), 1993-05, Vol.32 (20), p.5352-5364

1993

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Structural basis of anthracycline selectivity for unilamellar phosphatidylcholine vesicles: an equilibrium binding study

Biochemistry (Easton), 1985-03, Vol.24 (7), p.1768-1776

1985

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Synthesis and evaluation of a novel E-ring modified α-hydroxy keto ether analogue of camptothecin

Bioorganic & medicinal chemistry, 2002, Vol.10 (1), p.103-110

2002

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Ethyl substitution at the 7 position extends the half-life of 10-hydroxycamptothecin in the presence of human serum albumin

Journal of medicinal chemistry, 1993-08, Vol.36 (17), p.2580-2582

1993

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The effect of DB-67, a lipophilic camptothecin derivative, on topoisomerase I levels in non-small-cell lung cancer cells

Cancer chemotherapy and pharmacology, 2004-10, Vol.54 (4), p.354-360

2004

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Degradation of camptothecin-20( S)-glycinate ester prodrug under physiological conditions

Journal of pharmaceutical and biomedical analysis, 2004-09, Vol.35 (5), p.1113-1125

2004

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Determination of 9-nitrocamptothecin by precolumn derivatization and its metabolite 9-aminocamptothecin in a biological fluid using reversed-phase high-performance liquid chromatography with fluorescence detection

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2003-10, Vol.795 (2), p.309-318

2003

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Stabilization of Topotecan in Low pH Liposomes Composed of Distearoylphosphatidylcholine

Journal of pharmaceutical sciences, 1994-07, Vol.83 (7), p.967-969

1994

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Liposomal stabilization of camptothecin's lactone ring

Journal of the American Chemical Society, 1992-10, Vol.114 (21), p.8318-8319

1992

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Fluorescence Spectral Properties of the Anticancer Drug Topotecan by Steady-State and Frequency Domain Fluorometry with One-Photon and Multi-Photon Excitation

Photochemistry and photobiology, 1999-04, Vol.69 (4), p.421-428

1999

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An in vitro study of liposomal curcumin: Stability, toxicity and biological activity in human lymphocytes and Epstein-Barr virus-transformed human B-cells

The Novel Silatecan 7-tert-Butyldimethylsilyl-10-hydroxycamptothecin Displays High Lipophilicity, Improved Human Blood Stability, and Potent Anticancer Activity

Reduced Albumin Binding Promotes the Stability and Activity of Topotecan in Human Blood

The acidic microclimate in poly(lactide-co-glycolide) microspheres stabilizes camptothecins

The Novel Highly Lipophilic Topoisomerase I Inhibitor DB67 Is Effective in the Treatment of Liver Metastases of Murine CT-26 Colon Carcinoma

Differential Interactions of Camptothecin Lactone and Carboxylate Forms with Human Blood Components

Stabilization of 10-hydroxycamptothecin in poly(lactide-co-glycolide) microsphere delivery vehicles

Marked Interspecies Variations Concerning the Interactions of Camptothecin with Serum Albumins: A Frequency-Domain Fluorescence Spectroscopic Study

Novel A,B,E-Ring-Modified Camptothecins Displaying High Lipophilicity and Markedly Improved Human Blood Stabilities

Potent topoisomerase I inhibition by novel silatecans eliminates glioma proliferation in vitro and in vivo

DNA base modifications induced in isolated human chromatin by NADH dehydrogenase-catalyzed reduction of doxorubicin

A Versatile Prodrug Approach for Liposomal Core-Loading of Water-Insoluble Camptothecin Anticancer Drugs

DNA Interactions of Two Clinical Camptothecin Drugs Stabilize Their Active Lactone Forms

Plasma and tissue disposition of non-liposomal DB-67 and liposomal DB-67 in C.B-17 SCID mice

Analysis of human topoisomerase I inhibition and interaction with the cleavage site +1 deoxyguanosine, via in vitro experiments and molecular modeling studies

Lipid bilayer partitioning and stability of camptothecin drugs

Structural basis of anthracycline selectivity for unilamellar phosphatidylcholine vesicles: an equilibrium binding study

Synthesis and evaluation of a novel E-ring modified α-hydroxy keto ether analogue of camptothecin

Ethyl substitution at the 7 position extends the half-life of 10-hydroxycamptothecin in the presence of human serum albumin

The effect of DB-67, a lipophilic camptothecin derivative, on topoisomerase I levels in non-small-cell lung cancer cells

Degradation of camptothecin-20( S)-glycinate ester prodrug under physiological conditions

Determination of 9-nitrocamptothecin by precolumn derivatization and its metabolite 9-aminocamptothecin in a biological fluid using reversed-phase high-performance liquid chromatography with fluorescence detection

Stabilization of Topotecan in Low pH Liposomes Composed of Distearoylphosphatidylcholine

Liposomal stabilization of camptothecin's lactone ring

Fluorescence Spectral Properties of the Anticancer Drug Topotecan by Steady-State and Frequency Domain Fluorometry with One-Photon and Multi-Photon Excitation

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