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Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

Nature (London), 2016-03, Vol.531 (7594), p.335-340

2016

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Three-dimensional compound comparison methods and their application in drug discovery

Molecules (Basel, Switzerland), 2015-07, Vol.20 (7), p.12841-12862

2015

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PL-PatchSurfer: a novel molecular local surface-based method for exploring protein-ligand interactions

International journal of molecular sciences, 2014-08, Vol.15 (9), p.15122-15145

2014

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Metabotropic glutamate receptors as novel targets for anxiety and stress disorders

Nature reviews. Drug discovery, 2005-02, Vol.4 (2), p.131-144

2005

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Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu[subscript 2] Receptor Agonist

Journal of medicinal chemistry, 2016-03, Vol.58 ((18) ; 09, 2015)

2016

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Discovery of (1S,2R,3S,4S,5R,6R)‑2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity

Journal of medicinal chemistry, 2016-12, Vol.59 (24), p.10974-10993

2016

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Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S‑2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures

Journal of medicinal chemistry, 2015-02, Vol.58 (4), p.1776-1794

2015

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Synthesis and Pharmacological Characterization of C4‑(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)‑2-Amino-4-(1H‑1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist

Journal of medicinal chemistry, 2015-09, Vol.58 (18), p.7526-7548

2015

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Synthesis and Pharmacological Characterization of 4‑Substituted-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: Identification of New Potent and Selective Metabotropic Glutamate 2/3 Receptor Agonists

Journal of medicinal chemistry, 2013-06, Vol.56 (11), p.4442-4455

2013

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Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M1 agonists

Bioorganic & medicinal chemistry letters, 2015-10, Vol.25 (19), p.4158-4163

2015

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Computational methods in molecular diversity and combinatorial chemistry

Current opinion in chemical biology, 1998-06, Vol.2 (3), p.376-380

1998

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Ligand binding to domain-3 of human serum albumin: a chemometric analysis

Journal of computer-aided molecular design, 2003-02, Vol.17 (2-4), p.93-102

2003

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PatchSurfers: Two methods for local molecular property-based binding ligand prediction

Methods (San Diego, Calif.), 2016-01, Vol.93, p.41-50

2016

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Structural Basis for (S)‑3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu8 Receptor

Journal of medicinal chemistry, 2018-11, Vol.61 (22), p.10040-10052

2018

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PS-073-Preclinical profile of HBV core protein inhibitor, ABI-H, a potent inhibitor of cccDNA generation in HBV infected cells

Journal of hepatology, 2019-04, Vol.70 (1), p.e48-e48

2019

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A fast new approach to pharmacophore mapping and its application to dopaminergic and benzodiazepine agonists

Journal of computer-aided molecular design, 1993-02, Vol.7 (1), p.83-102

1993

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Privileged Molecules for Protein Binding Identified from NMR-Based Screening

Journal of medicinal chemistry, 2000-09, Vol.43 (18), p.3443-3447

2000

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Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1 S ,2 S ,5 R ,6 S -2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures

Journal of medicinal chemistry, 2015-02, Vol.58 (4), p.1776-1794

2015

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Discovery of a Potent Inhibitor of the Antiapoptotic Protein Bcl-x L from NMR and Parallel Synthesis

Journal of medicinal chemistry, 2006-01, Vol.49 (2), p.656-663

2006

Volltextzugriff (PDF)

Structural Basis for ( S)-3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu 8 Receptor

Journal of medicinal chemistry, 2018-11, Vol.61 (22), p.10040-10052

2018

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Discovery of a Potent Inhibitor of the Antiapoptotic Protein Bcl-xL from NMR and Parallel Synthesis

Journal of medicinal chemistry, 2006-01, Vol.49 (2), p.656-663

2006

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Synthesis and Metabotropic Glutamate Receptor Activity of S-Oxidized Variants of (−)-4-Amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate: Identification of Potent, Selective, and Orally Bioavailable Agonists for mGlu2/3 Receptors

Journal of medicinal chemistry, 2007-01, Vol.50 (2), p.233-240

2007

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Synthesis and Pharmacological Characterization of C 4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 R ,2 S ,4 R ,5 R ,6 R )-2-Amino-4-(1 H -1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu 2 Receptor Agonist

Journal of medicinal chemistry, 2015-09, Vol.58 (18), p.7526-7548

2015

Volltextzugriff (PDF)

Methyl Substitution of 2-Aminobicyclo[3.1.0]hexane 2,6-Dicarboxylate (LY354740) Determines Functional Activity at Metabotropic Glutamate Receptors: Identification of a Subtype Selective mGlu2 Receptor Agonist

Journal of medicinal chemistry, 2005-05, Vol.48 (10), p.3605-3612

2005

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Mechanism of differential activities of ofloxacin enantiomers

Antimicrobial Agents and Chemotherapy, 1996-08, Vol.40 (8), p.1775-1784

1996

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Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

Three-dimensional compound comparison methods and their application in drug discovery

PL-PatchSurfer: a novel molecular local surface-based method for exploring protein-ligand interactions

Metabotropic glutamate receptors as novel targets for anxiety and stress disorders

Discovery of (1S,2R,3S,4S,5R,6R)‑2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity

Synthesis and Pharmacological Characterization of 4‑Substituted-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: Identification of New Potent and Selective Metabotropic Glutamate 2/3 Receptor Agonists

Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M1 agonists

Computational methods in molecular diversity and combinatorial chemistry

Ligand binding to domain-3 of human serum albumin: a chemometric analysis

PatchSurfers: Two methods for local molecular property-based binding ligand prediction

Structural Basis for (S)‑3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu8 Receptor

PS-073-Preclinical profile of HBV core protein inhibitor, ABI-H, a potent inhibitor of cccDNA generation in HBV infected cells

A fast new approach to pharmacophore mapping and its application to dopaminergic and benzodiazepine agonists

Privileged Molecules for Protein Binding Identified from NMR-Based Screening

Discovery of a Potent Inhibitor of the Antiapoptotic Protein Bcl-x L from NMR and Parallel Synthesis

Structural Basis for ( S)-3,4-Dicarboxyphenylglycine (DCPG) As a Potent and Subtype Selective Agonist of the mGlu 8 Receptor

Discovery of a Potent Inhibitor of the Antiapoptotic Protein Bcl-xL from NMR and Parallel Synthesis

Synthesis and Metabotropic Glutamate Receptor Activity of S-Oxidized Variants of (−)-4-Amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate: Identification of Potent, Selective, and Orally Bioavailable Agonists for mGlu2/3 Receptors

Methyl Substitution of 2-Aminobicyclo[3.1.0]hexane 2,6-Dicarboxylate (LY354740) Determines Functional Activity at Metabotropic Glutamate Receptors: Identification of a Subtype Selective mGlu2 Receptor Agonist

Mechanism of differential activities of ofloxacin enantiomers

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