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Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides

Nucleic acids research, 2021-09, Vol.49 (16), p.9026-9041

2021

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Plasmonic‐Based Mechanochromic Microcapsules as Strain Sensors

Small (Weinheim an der Bergstrasse, Germany), 2017-10, Vol.13 (39), p.n/a

2017

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Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts

Nucleic acids research, 2016-03, Vol.44 (5), p.2093-2109

2016

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Integrated Safety Assessment of 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers

Molecular therapy, 2016-10, Vol.24 (10), p.1771-1782

2016

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Comprehensive Structure–Activity Relationship of Triantennary N‑Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes

Journal of medicinal chemistry, 2016-03, Vol.59 (6), p.2718-2733

2016

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Granulosa cells provide elimination of apoptotic oocytes through unconventional autophagy-assisted phagocytosis

Human reproduction (Oxford), 2020-06, Vol.35 (6), p.1346-1362

2020

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AML1-ETO Expression is Directly Involved in the Development of Acute Myeloid Leukemia in the Presence of Additional Mutations

Proceedings of the National Academy of Sciences - PNAS, 2001-08, Vol.98 (18), p.10398-10403

2001

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Correlations between preclinical BJAB assay ranking of antisense drugs and clinical trial adverse events

Clinical and translational science, 2023-04, Vol.16 (4), p.575-580

2023

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Characterization of aluminum, aluminum oxide and titanium dioxide nanomaterials using a combination of methods for particle surface and size analysis

RSC advances, 2018-04, Vol.8 (26), p.14377-14388

2018

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Bacteroides fragilis prevents Salmonella Heidelberg translocation in co-culture model mimicking intestinal epithelium

Beneficial microbes, 2020-08, Vol.11 (4), p.391-402

2020

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Dichotomy of AML1-ETO Functions: Growth Arrest versus Block of Differentiation

Molecular and Cellular Biology, 2001-08, Vol.21 (16), p.5577-5590

2001

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Preclinical evaluation of the toxicological effects of a novel constrained ethyl modified antisense compound targeting signal transducer and activator of transcription 3 in mice and cynomolgus monkeys

Nucleic acid therapeutics, 2013-06, Vol.23 (3), p.213-227

2013

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Deletion of an AML1-ETO C-Terminal NcoR/SMRT-Interacting Region Strongly Induces Leukemia Development

Proceedings of the National Academy of Sciences - PNAS, 2004-12, Vol.101 (49), p.17186-17191

2004

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Update on the cellular and molecular aspects of cystic fibrosis transmembrane conductance regulator (CFTR) and male fertility

Morphologie, 2019-03, Vol.103 (341), p.4-10

2019

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Early-Stage Identification and Avoidance of Antisense Oligonucleotides Causing Species-Specific Inflammatory Responses in Human Volunteer Peripheral Blood Mononuclear Cells

Nucleic acid therapeutics, 2022-12, Vol.32 (6), p.457-472

2022

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Inflammatory Non-CpG Antisense Oligonucleotides Are Signaling Through TLR9 in Human Burkitt Lymphoma B Bjab Cells

Nucleic acid therapeutics, 2022-12, Vol.32 (6), p.473-485

2022

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Investigation into the Mechanism(s) That Leads to Platelet Decreases in Cynomolgus Monkeys During Administration of ISIS 104838, a 2ʹ-MOE-Modified Antisense Oligonucleotide

Toxicological sciences, 2018-08, Vol.164 (2), p.613-626

2018

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CDKN2A homozygous deletion is a strong adverse prognosis factor in diffuse malignant IDH-mutant gliomas

Neuro-oncology (Charlottesville, Va.), 2019-07, Vol.21 (12), p.1519-1528

2019

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Underlying Immune Disorder May Predispose Some Transthyretin Amyloidosis Subjects to Inotersen-Mediated Thrombocytopenia

Nucleic acid therapeutics, 2020-04, Vol.30 (2), p.94-103

2020

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Assessment of the Effects of 2'-Methoxyethyl Antisense Oligonucleotides on Platelet Count in Cynomolgus Nonhuman Primates

Nucleic acid therapeutics, 2017-08, Vol.27 (4), p.197-208

2017

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Increased prevalence of granulovacuolar degeneration in C9orf72 mutation

Acta neuropathologica, 2019-11, Vol.138 (5), p.783-793

2019

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Structural characterization of heat-induced protein aggregates in model infant milk formulas

Food hydrocolloids, 2020-10, Vol.107, p.105928, Article 105928

2020

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P12-03 Hepatotoxicity induced by a mixture of PAHs: role of extracellular vesicles

Toxicology letters, 2024-09, Vol.399, p.S200-S200

2024

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Hybrid Mouse Diversity Panel Identifies Genetic Architecture Associated with the Acute Antisense Oligonucleotide-Mediated Inflammatory Response to a 2'- O -Methoxyethyl Antisense Oligonucleotide

Nucleic acid therapeutics, 2019-10, Vol.29 (5), p.266-277

2019

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Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides

Plasmonic‐Based Mechanochromic Microcapsules as Strain Sensors

Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts

Integrated Safety Assessment of 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers

Comprehensive Structure–Activity Relationship of Triantennary N‑Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes

Granulosa cells provide elimination of apoptotic oocytes through unconventional autophagy-assisted phagocytosis

AML1-ETO Expression is Directly Involved in the Development of Acute Myeloid Leukemia in the Presence of Additional Mutations

Correlations between preclinical BJAB assay ranking of antisense drugs and clinical trial adverse events

Characterization of aluminum, aluminum oxide and titanium dioxide nanomaterials using a combination of methods for particle surface and size analysis

Bacteroides fragilis prevents Salmonella Heidelberg translocation in co-culture model mimicking intestinal epithelium

Dichotomy of AML1-ETO Functions: Growth Arrest versus Block of Differentiation

Preclinical evaluation of the toxicological effects of a novel constrained ethyl modified antisense compound targeting signal transducer and activator of transcription 3 in mice and cynomolgus monkeys

Deletion of an AML1-ETO C-Terminal NcoR/SMRT-Interacting Region Strongly Induces Leukemia Development

Update on the cellular and molecular aspects of cystic fibrosis transmembrane conductance regulator (CFTR) and male fertility

Early-Stage Identification and Avoidance of Antisense Oligonucleotides Causing Species-Specific Inflammatory Responses in Human Volunteer Peripheral Blood Mononuclear Cells

Inflammatory Non-CpG Antisense Oligonucleotides Are Signaling Through TLR9 in Human Burkitt Lymphoma B Bjab Cells

Investigation into the Mechanism(s) That Leads to Platelet Decreases in Cynomolgus Monkeys During Administration of ISIS 104838, a 2ʹ-MOE-Modified Antisense Oligonucleotide

Mechanical Thrombectomy for Acute Ischemic Stroke Amid the COVID-19 Outbreak: Decreased Activity, and Increased Care Delays

CDKN2A homozygous deletion is a strong adverse prognosis factor in diffuse malignant IDH-mutant gliomas

Underlying Immune Disorder May Predispose Some Transthyretin Amyloidosis Subjects to Inotersen-Mediated Thrombocytopenia

Assessment of the Effects of 2'-Methoxyethyl Antisense Oligonucleotides on Platelet Count in Cynomolgus Nonhuman Primates

Increased prevalence of granulovacuolar degeneration in C9orf72 mutation

Structural characterization of heat-induced protein aggregates in model infant milk formulas

P12-03 Hepatotoxicity induced by a mixture of PAHs: role of extracellular vesicles

Hybrid Mouse Diversity Panel Identifies Genetic Architecture Associated with the Acute Antisense Oligonucleotide-Mediated Inflammatory Response to a 2'- O -Methoxyethyl Antisense Oligonucleotide

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