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Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities

Nature reviews. Neurology, 2020-07, Vol.16 (7), p.381

2020

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Expression profiling of human immune cell subsets identifies miRNA-mRNA regulatory relationships correlated with cell type specific expression

PloS one, 2012-01, Vol.7 (1), p.e29979-e29979

2012

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The multifaceted exosome: Biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities

Biochemical pharmacology, 2012-06, Vol.83 (11), p.1484-1494

2012

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Safety, Pharmacokinetics, and Pharmacodynamics of Single Doses of LXR-623, a Novel Liver X-Receptor Agonist, in Healthy Participants

Journal of clinical pharmacology, 2009-06, Vol.49 (6), p.643-649

2009

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Single-cell RNA transcriptome landscape of hepatocytes and non-parenchymal cells in healthy and NAFLD mouse liver

iScience, 2021-11, Vol.24 (11), p.103233-103233, Article 103233

2021

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Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse

Molecular neurodegeneration, 2018-05, Vol.13 (1), p.25-25, Article 25

2018

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Biomarkers in the pharmaceutical industry

Clinical chemistry (Baltimore, Md.), 2015-04, Vol.61 (4), p.579-583

2015

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Molecular Classification of Crohn's Disease and Ulcerative Colitis Patients Using Transcriptional Profiles in Peripheral Blood Mononuclear Cells

The Journal of molecular diagnostics : JMD, 2006-02, Vol.8 (1), p.51-61

2006

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Dihydrodiol Dehydrogenases and Polycyclic Aromatic Hydrocarbon Activation: Generation of Reactive and Redox Active o-Quinones

Chemical research in toxicology, 1999-01, Vol.12 (1), p.1-18

1999

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An assessment of drug-drug interactions: the effect of desvenlafaxine and duloxetine on the pharmacokinetics of the CYP2D6 probe desipramine in healthy subjects

Drug metabolism and disposition, 2008-12, Vol.36 (12), p.2484

2008

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Transcriptional Profiles in Peripheral Blood Mononuclear Cells Prognostic of Clinical Outcomes in Patients with Advanced Renal Cell Carcinoma

Clinical cancer research, 2005-02, Vol.11 (3), p.1181-1189

2005

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Approaches and limitations of phosphatidylinositol-3-kinase pathway activation status as a predictive biomarker in the clinical development of targeted therapy

Breast cancer research and treatment, 2010-11, Vol.124 (1), p.1-11

2010

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Perturbed liver gene zonation in a mouse model of non-alcoholic steatohepatitis

Metabolism, clinical and experimental, 2024-05, Vol.154, p.155830-155830, Article 155830

2024

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Evaluating the efficacy and safety of pozelimab in patients with CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy disease: an open-label phase 2 and 3 study

The Lancet (British edition), 2024-02, Vol.403 (10427), p.645-656

2024

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Glutaminase 2 knockdown reduces hyperammonemia and associated lethality of urea cycle disorder mouse model

Journal of inherited metabolic disease, 2022-05, Vol.45 (3), p.470-480

2022

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Expression and Characterization of Four Recombinant Human Dihydrodiol Dehydrogenase Isoforms: Oxidation of trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene to the Activated o-Quinone Metabolite Benzo[a]pyrene-7,8-dione

Biochemistry (Easton), 1998-05, Vol.37 (19), p.6781-6790

1998

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Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells

Journal of translational medicine, 2008-10, Vol.6 (1), p.59-59, Article 59

2008

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Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease

The Journal of pharmacology and experimental therapeutics, 2009-11, Vol.331 (2), p.598

2009

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Measurement of myostatin concentrations in human serum: Circulating concentrations in young and older men and effects of testosterone administration

Molecular and cellular endocrinology, 2009-04, Vol.302 (1), p.26-32

2009

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Comparison of the Pharmacokinetics of Venlafaxine Extended Release and Desvenlafaxine in Extensive and Poor Cytochrome P450 2D6 Metabolizers

Journal of clinical psychopharmacology, 2009-02, Vol.29 (1), p.39-43

2009

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Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells

Toxicological sciences, 2000-12, Vol.58 (2), p.399-415

2000

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Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor

Cancer research (Chicago, Ill.), 2000-02, Vol.60 (4), p.908-915

2000

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The Ubiquitous Aldehyde Reductase (AKR1A1) Oxidizes Proximate Carcinogen trans-Dihydrodiols to o-Quinones: Potential Role in Polycyclic Aromatic Hydrocarbon Activation

Biochemistry (Easton), 2001-09, Vol.40 (36), p.10901-10910

2001

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Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress : Implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase

Cancer research (Chicago, Ill.), 1999-02, Vol.59 (3), p.607-614

1999

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Population Pharmacokinetics of CCI-779: Correlations to Safety and Pharmacogenomic Responses in Patients with Advanced Renal Cancer

Clinical pharmacology and therapeutics, 2005-01, Vol.77 (1), p.76-89

2005

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Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities

Expression profiling of human immune cell subsets identifies miRNA-mRNA regulatory relationships correlated with cell type specific expression

The multifaceted exosome: Biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities

Safety, Pharmacokinetics, and Pharmacodynamics of Single Doses of LXR-623, a Novel Liver X-Receptor Agonist, in Healthy Participants

Single-cell RNA transcriptome landscape of hepatocytes and non-parenchymal cells in healthy and NAFLD mouse liver

Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse

Biomarkers in the pharmaceutical industry

Molecular Classification of Crohn's Disease and Ulcerative Colitis Patients Using Transcriptional Profiles in Peripheral Blood Mononuclear Cells

Dihydrodiol Dehydrogenases and Polycyclic Aromatic Hydrocarbon Activation: Generation of Reactive and Redox Active o-Quinones

An assessment of drug-drug interactions: the effect of desvenlafaxine and duloxetine on the pharmacokinetics of the CYP2D6 probe desipramine in healthy subjects

Transcriptional Profiles in Peripheral Blood Mononuclear Cells Prognostic of Clinical Outcomes in Patients with Advanced Renal Cell Carcinoma

Approaches and limitations of phosphatidylinositol-3-kinase pathway activation status as a predictive biomarker in the clinical development of targeted therapy

Perturbed liver gene zonation in a mouse model of non-alcoholic steatohepatitis

Evaluating the efficacy and safety of pozelimab in patients with CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, and protein-losing enteropathy disease: an open-label phase 2 and 3 study

Glutaminase 2 knockdown reduces hyperammonemia and associated lethality of urea cycle disorder mouse model

Expression and Characterization of Four Recombinant Human Dihydrodiol Dehydrogenase Isoforms: Oxidation of trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene to the Activated o-Quinone Metabolite Benzo[a]pyrene-7,8-dione

Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells

Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease

Measurement of myostatin concentrations in human serum: Circulating concentrations in young and older men and effects of testosterone administration

Comparison of the Pharmacokinetics of Venlafaxine Extended Release and Desvenlafaxine in Extensive and Poor Cytochrome P450 2D6 Metabolizers

Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells

Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor

The Ubiquitous Aldehyde Reductase (AKR1A1) Oxidizes Proximate Carcinogen trans-Dihydrodiols to o-Quinones: Potential Role in Polycyclic Aromatic Hydrocarbon Activation

Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress : Implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase

Population Pharmacokinetics of CCI-779: Correlations to Safety and Pharmacogenomic Responses in Patients with Advanced Renal Cancer

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