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Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells

Toxicological sciences, 2000-12, Vol.58 (2), p.399-415

2000

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Pyrosequencing-based methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours

British journal of cancer, 2011-07, Vol.105 (2), p.246-254

2011

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Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor

Cancer research (Chicago, Ill.), 2000-02, Vol.60 (4), p.908-915

2000

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The Ubiquitous Aldehyde Reductase (AKR1A1) Oxidizes Proximate Carcinogen trans-Dihydrodiols to o-Quinones: Potential Role in Polycyclic Aromatic Hydrocarbon Activation

Biochemistry (Easton), 2001-09, Vol.40 (36), p.10901-10910

2001

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Pharmacogenomic approaches in clinical studies to identify biomarkers of safety and efficacy

Toxicology letters, 2009-04, Vol.186 (1), p.18-21

Burczynski, M.E.

2009

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Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress : Implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase

Cancer research (Chicago, Ill.), 1999-02, Vol.59 (3), p.607-614

1999

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Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1‒AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones

Biochemical journal, 2000-10, Vol.351 (1), p.67

2000

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Dihydrodiol Dehydrogenases and Polycyclic Aromatic Hydrocarbon Activation: Generation of Reactive and Redox Active o-Quinones

Chemical research in toxicology, 1999-01, Vol.12 (1), p.1-18

1999

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Cytochrome P450 induction in rat hepatocytes assessed by quantitative real-time reverse-transcription polymerase chain reaction and the RNA invasive cleavage assay

Drug metabolism and disposition, 2001-09, Vol.29 (9), p.1243

2001

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Expression and Characterization of Four Recombinant Human Dihydrodiol Dehydrogenase Isoforms: Oxidation of trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene to the Activated o-Quinone Metabolite Benzo[a]pyrene-7,8-dione

Biochemistry (Easton), 1998-05, Vol.37 (19), p.6781-6790

1998

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Pharmacogenomic approaches in clinical studies to identify biomarkers of safety and efficacy: Toxicogenomics and Clinical Toxicology

Toxicology letters, 2009, Vol.186 (1), p.18-21

BURCZYNSKI, M. E

2009

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Disposition and Biological Activity of Benzo[a]pyrene-7,8-dione. A Genotoxic Metabolite Generated by Dihydrodiol Dehydrogenase

Biochemistry (Easton), 1996-10, Vol.35 (42), p.13664-13672

1996

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The Reactive Oxygen Species- and Michael Acceptor-inducible Human Aldo-Keto Reductase AKR1C1 Reduces the α,β-Unsaturated Aldehyde 4-Hydroxy-2-nonenal to 1,4-Dihydroxy-2-nonene

The Journal of biological chemistry, 2001-01, Vol.276 (4), p.2890-2897

2001

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Metabolic activation of polycyclic aromatic hydrocarbon trans-dihydrodiols by ubiquitously expressed aldehyde reductase (AKR1A1)

Chemico-biological interactions, 2001-01, Vol.130 (1-3), p.815-824

2001

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Transcriptional profiling of peripheral blood cells in clinical pharmacogenomic studies

Pharmacogenomics, 2006-03, Vol.7 (2), p.187-202

2006

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Molecular Classification of Crohn's Disease and Ulcerative Colitis Patients Using Transcriptional Profiles in Peripheral Blood Mononuclear Cells

The Journal of molecular diagnostics : JMD, 2006-02, Vol.8 (1), p.51-61

2006

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Nile Red binding to HepG2 cells: An improved assay for in vitro studies of hepatosteatosis

In vitro & molecular toxicology, 2001, Vol.14 (3), p.177-190

2001

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Comparison of the Pharmacokinetics of Venlafaxine Extended Release and Desvenlafaxine in Extensive and Poor Cytochrome P450 2D6 Metabolizers

Journal of clinical psychopharmacology, 2009-02, Vol.29 (1), p.39-43

2009

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Transcriptional Profiles in Peripheral Blood Mononuclear Cells Prognostic of Clinical Outcomes in Patients with Advanced Renal Cell Carcinoma

Clinical cancer research, 2005-02, Vol.11 (3), p.1181-1189

2005

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Population Pharmacokinetics of CCI-779: Correlations to Safety and Pharmacogenomic Responses in Patients with Advanced Renal Cancer

Clinical pharmacology and therapeutics, 2005-01, Vol.77 (1), p.76-89

2005

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Disease-associated expression profiles in peripheral blood mononuclear cells from patients with advanced renal cell carcinoma

Cancer research (Chicago, Ill.), 2003-09, Vol.63 (18), p.6069-6075

2003

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Analytical validation of a highly sensitive microparticle-based immunoassay for the quantitation of IL-13 in human serum using the Erenna® immunoassay system

Journal of immunological methods, 2009-10, Vol.350 (1), p.161-170

2009

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Surrogate tissue analysis: monitoring toxicant exposure and health status of inaccessible tissues through the analysis of accessible tissues and cells

Toxicology and applied pharmacology, 2004-01, Vol.194 (2), p.189-199

2004

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Use of ex vivo systems for biomarker discovery

Current opinion in pharmacology, 2008-10, Vol.8 (5), p.647-653

2008

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Clinical pharmacogenomics and transcriptional profiling in early phase oncology clinical trials

Current molecular medicine, 2005-02, Vol.5 (1), p.83

2005

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Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells

Pyrosequencing-based methods reveal marked inter-individual differences in oncogene mutation burden in human colorectal tumours

Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor

The Ubiquitous Aldehyde Reductase (AKR1A1) Oxidizes Proximate Carcinogen trans-Dihydrodiols to o-Quinones: Potential Role in Polycyclic Aromatic Hydrocarbon Activation

Pharmacogenomic approaches in clinical studies to identify biomarkers of safety and efficacy

Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress : Implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase

Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1‒AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones

Dihydrodiol Dehydrogenases and Polycyclic Aromatic Hydrocarbon Activation: Generation of Reactive and Redox Active o-Quinones

Cytochrome P450 induction in rat hepatocytes assessed by quantitative real-time reverse-transcription polymerase chain reaction and the RNA invasive cleavage assay

Expression and Characterization of Four Recombinant Human Dihydrodiol Dehydrogenase Isoforms: Oxidation of trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene to the Activated o-Quinone Metabolite Benzo[a]pyrene-7,8-dione

Pharmacogenomic approaches in clinical studies to identify biomarkers of safety and efficacy: Toxicogenomics and Clinical Toxicology

Disposition and Biological Activity of Benzo[a]pyrene-7,8-dione. A Genotoxic Metabolite Generated by Dihydrodiol Dehydrogenase

The Reactive Oxygen Species- and Michael Acceptor-inducible Human Aldo-Keto Reductase AKR1C1 Reduces the α,β-Unsaturated Aldehyde 4-Hydroxy-2-nonenal to 1,4-Dihydroxy-2-nonene

Metabolic activation of polycyclic aromatic hydrocarbon trans-dihydrodiols by ubiquitously expressed aldehyde reductase (AKR1A1)

Transcriptional profiling of peripheral blood cells in clinical pharmacogenomic studies

Molecular Classification of Crohn's Disease and Ulcerative Colitis Patients Using Transcriptional Profiles in Peripheral Blood Mononuclear Cells

Nile Red binding to HepG2 cells: An improved assay for in vitro studies of hepatosteatosis

Comparison of the Pharmacokinetics of Venlafaxine Extended Release and Desvenlafaxine in Extensive and Poor Cytochrome P450 2D6 Metabolizers

Transcriptional Profiles in Peripheral Blood Mononuclear Cells Prognostic of Clinical Outcomes in Patients with Advanced Renal Cell Carcinoma

Population Pharmacokinetics of CCI-779: Correlations to Safety and Pharmacogenomic Responses in Patients with Advanced Renal Cancer

Disease-associated expression profiles in peripheral blood mononuclear cells from patients with advanced renal cell carcinoma

Analytical validation of a highly sensitive microparticle-based immunoassay for the quantitation of IL-13 in human serum using the Erenna® immunoassay system

Surrogate tissue analysis: monitoring toxicant exposure and health status of inaccessible tissues through the analysis of accessible tissues and cells

Use of ex vivo systems for biomarker discovery

Clinical pharmacogenomics and transcriptional profiling in early phase oncology clinical trials

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