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Randomized proof of concept trial of GLYX-13, an N-methyl-D-aspartate receptor glycine site partial agonist, in major depressive disorder nonresponsive to a previous antidepressant agent

Journal of psychiatric practice, 2015-03, Vol.21 (2), p.140-149

2015

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The Development of Rapastinel (Formerly GLYX-13); A Rapid Acting and Long Lasting Antidepressant

Current neuropharmacology, 2017-01, Vol.15 (1), p.47-56

2017

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Thiocarbazate building blocks enable the construction of azapeptides for rapid development of therapeutic candidates

Nature communications, 2022-11, Vol.13 (1), p.7127-7127, Article 7127

2022

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Effect of a Novel NMDA Receptor Modulator, Rapastinel (Formerly GLYX-13), in OCD: Proof of Concept

The American journal of psychiatry, 2016-12, Vol.173 (12), p.1239-1241

2016

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Rapastinel (GLYX-13) has therapeutic potential for the treatment of post-traumatic stress disorder: Characterization of a NMDA receptor-mediated metaplasticity process in the medial prefrontal cortex of rats

Behavioural brain research, 2015-11, Vol.294, p.177-185

2015

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Effects of Rapastinel (Formerly GLYX-13) on Serum Brain-Derived Neurotrophic Factor in Obsessive-Compulsive Disorder

The journal of clinical psychiatry, 2018-01, Vol.79 (1), p.17

2018

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Pharmacokinetic and pharmacodynamic profile following oral administration of the phosphodiesterase (PDE)4 inhibitor V11294A in healthy volunteers

British journal of clinical pharmacology, 2002-11, Vol.54 (5), p.478-484

2002

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Receptor-mediated activation of phospholipase A2 via GTP-binding proteins: arachidonic acid and its metabolites as second messengers

Trends in neurosciences (Regular ed.), 1988-03, Vol.11 (3), p.117-123

1988

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The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus

Neuroscience, 2015-11, Vol.308, p.202-211

2015

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Bradykinin stimulates tumor necrosis factor and interleukin-1 release from macrophages

FEBS letters, 1989-04, Vol.247 (2), p.189-192

1989

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Recent developments in the understanding of bradykinin receptors

Life Sciences, 1992, Vol.50 (12), p.829-838

1992

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Inhibition of neutrophil adhesion during cardiopulmonary bypass

The Annals of thoracic surgery, 1994, Vol.57 (1), p.126-133

1994

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Pharmacology of a new cyclic nucleotide phosphodiesterase type 4 inhibitor, V11294

Pulmonary pharmacology & therapeutics, 2003-01, Vol.16 (2), p.97-104

2003

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Diacylglycerol stimulates phospholipase A2 from Swiss 3T3 fibroblasts

FEBS letters, 1988-07, Vol.234 (2), p.283-286

Burch, Ronald M.

1988

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Design and conformational analysis of several highly potent bradykinin receptor antagonists

Journal of medicinal chemistry, 1991-03, Vol.34 (3), p.1230-1233

1991

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Probing the bradykinin receptor: mapping the geometric topography using ethers of hydroxyproline in novel peptides

Journal of medicinal chemistry, 1991-08, Vol.34 (8), p.2649-2653

1991

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A bradykinin antagonist inhibits carrageenan edema in rats

Naunyn-Schmiedeberg's archives of pharmacology, 1990-08, Vol.342 (2), p.189-193

1990

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Management of Accidental Spinal Administration of Extended-release Epidural Morphine. Authors' reply

Anesthesiology (Philadelphia), 2008, Vol.108 (6), p.1147-1149

2008

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Kinin Signal Transduction: Role of Phosphoinositides and Eicosanoids

Journal of cardiovascular pharmacology, 1990, Vol.15 Suppl 6, p.S44-S45

Burch, Ronald M

1990

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Design and conformational analysis of several highly potent bradykinin receptor antagonists. [Erratum to document cited in CA114(15):144010y]

Journal of medicinal chemistry, 1993-07, Vol.36 (14), p.2050-2050

1993

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Dissociation of Bradykinin-Induced Prostaglandin Formation from Phosphatidylinositol Turnover in Swiss 3T3 Fibroblasts: Evidence for G Protein Regulation of Phospholipase A2

Proceedings of the National Academy of Sciences - PNAS, 1987-09, Vol.84 (18), p.6374-6378

1987

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Biochemical and molecular pharmacology of kinin receptors

Annual review of pharmacology and toxicology, 1992-01, Vol.32 (1), p.511-536

1992

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Phospholipase A2 and Phospholipase C are Activated by Distinct GTP-Binding Proteins in Response to α 1-adrenergic Stimulation in FRTL5 Thyroid Cells

Proceedings of the National Academy of Sciences - PNAS, 1986-10, Vol.83 (19), p.7201-7205

1986

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Substituted 2-(aminomethyl)piperidines: a novel class of selective protein kinase C inhibitors

Journal of medicinal chemistry, 1991-09, Vol.34 (9), p.2928-2931

1991

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Interleukin 1 Amplifies Receptor-Mediated Activation of Phospholipase A2 in 3T3 Fibroblasts

Proceedings of the National Academy of Sciences - PNAS, 1988-09, Vol.85 (17), p.6306-6309

1988

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Randomized proof of concept trial of GLYX-13, an N-methyl-D-aspartate receptor glycine site partial agonist, in major depressive disorder nonresponsive to a previous antidepressant agent

The Development of Rapastinel (Formerly GLYX-13); A Rapid Acting and Long Lasting Antidepressant

Thiocarbazate building blocks enable the construction of azapeptides for rapid development of therapeutic candidates

Effect of a Novel NMDA Receptor Modulator, Rapastinel (Formerly GLYX-13), in OCD: Proof of Concept

Rapastinel (GLYX-13) has therapeutic potential for the treatment of post-traumatic stress disorder: Characterization of a NMDA receptor-mediated metaplasticity process in the medial prefrontal cortex of rats

Effects of Rapastinel (Formerly GLYX-13) on Serum Brain-Derived Neurotrophic Factor in Obsessive-Compulsive Disorder

Pharmacokinetic and pharmacodynamic profile following oral administration of the phosphodiesterase (PDE)4 inhibitor V11294A in healthy volunteers

Receptor-mediated activation of phospholipase A2 via GTP-binding proteins: arachidonic acid and its metabolites as second messengers

The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus

Bradykinin stimulates tumor necrosis factor and interleukin-1 release from macrophages

Recent developments in the understanding of bradykinin receptors

Inhibition of neutrophil adhesion during cardiopulmonary bypass

Pharmacology of a new cyclic nucleotide phosphodiesterase type 4 inhibitor, V11294

Diacylglycerol stimulates phospholipase A2 from Swiss 3T3 fibroblasts

Design and conformational analysis of several highly potent bradykinin receptor antagonists

Probing the bradykinin receptor: mapping the geometric topography using ethers of hydroxyproline in novel peptides

A bradykinin antagonist inhibits carrageenan edema in rats

Management of Accidental Spinal Administration of Extended-release Epidural Morphine. Authors' reply

Kinin Signal Transduction: Role of Phosphoinositides and Eicosanoids

Design and conformational analysis of several highly potent bradykinin receptor antagonists. [Erratum to document cited in CA114(15):144010y]

Dissociation of Bradykinin-Induced Prostaglandin Formation from Phosphatidylinositol Turnover in Swiss 3T3 Fibroblasts: Evidence for G Protein Regulation of Phospholipase A2

Biochemical and molecular pharmacology of kinin receptors

Phospholipase A2 and Phospholipase C are Activated by Distinct GTP-Binding Proteins in Response to α 1-adrenergic Stimulation in FRTL5 Thyroid Cells

Substituted 2-(aminomethyl)piperidines: a novel class of selective protein kinase C inhibitors

Interleukin 1 Amplifies Receptor-Mediated Activation of Phospholipase A2 in 3T3 Fibroblasts

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