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Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses

Bioorganic & medicinal chemistry letters, 2014-02, Vol.24 (3), p.917-922

2014

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Enantioselective total synthesis of callipeltoside A: two approaches to the macrolactone fragment

Tetrahedron, 2008-05, Vol.64 (21), p.4671-4699

2008

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Could AlphaFold revolutionize chemical therapeutics?

Nature structural & molecular biology, 2021-10, Vol.28 (10), p.771

2021

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One-Pot Synthesis of Benzofurans via Palladium-Catalyzed Enolate Arylation with o-Bromophenols

Organic letters, 2008-10, Vol.10 (19), p.4211-4214

2008

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Enantioselective Total Synthesis of Callipeltoside A

Journal of the American Chemical Society, 2002-05, Vol.124 (20), p.5654-5655

2002

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Total Synthesis of Aflastatin A

Journal of the American Chemical Society, 2022-11, Vol.144 (43), p.19953-19972

2022

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Fragment Molecular Orbital Method Applied to Lead Optimization of Novel Interleukin‑2 Inducible T‑Cell Kinase (ITK) Inhibitors

Journal of medicinal chemistry, 2016-05, Vol.59 (9), p.4352-4363

2016

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Novel pyridone EP4 agonists featuring allylic alcohol ω-chains

Bioorganic & medicinal chemistry letters, 2020-05, Vol.30 (10), p.127104-127104, Article 127104

2020

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Mutual antagonistic relationship between prostaglandin E₂ and IFN-γ: Implications for rheumatoid arthritis

European journal of immunology, 2008-07, Vol.38 (7), p.1900-1912

2008

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Complex Aldol Reactions for the Construction of Dense Polyol Stereoarrays: Synthesis of the C33−C36 Region of Aflastatin A

Organic letters, 2005-07, Vol.7 (15), p.3331-3333

2005

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Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors

Journal of medicinal chemistry, 2014-02, Vol.57 (3), p.1033-1045

2014

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Tetrahydroindazoles as Interleukin‑2 Inducible T‑Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo

Journal of medicinal chemistry, 2015-05, Vol.58 (9), p.3806-3816

2015

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Property- and Structure-Guided Discovery of a Tetrahydroindazole Series of Interleukin‑2 Inducible T‑Cell Kinase Inhibitors

Journal of medicinal chemistry, 2014-07, Vol.57 (13), p.5714-5727

2014

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Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors

Bioorganic & medicinal chemistry letters, 2014-06, Vol.24 (11), p.2448-2452

2014

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Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK)

Bioorganic & medicinal chemistry letters, 2014-12, Vol.24 (24), p.5818-5823

2014

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Structure-based design and synthesis of potent benzothiazole inhibitors of interleukin-2 inducible T cell kinase (ITK)

Bioorganic & medicinal chemistry letters, 2013-12, Vol.23 (23), p.6331-6335

2013

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Mutual antagonistic relationship between prostaglandin E 2 and IFN‐γ: Implications for rheumatoid arthritis

European journal of immunology, 2008-07, Vol.38 (7), p.1900-1912

2008

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Asymmetric Synthesis of the Chlorocyclopropane-Containing Callipeltoside A Side Chain

Organic letters, 2001-02, Vol.3 (4), p.503-505

2001

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Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP₄ receptor

Bioorganic & medicinal chemistry letters, 2011-02, Vol.21 (3), p.1041-1046

2011

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Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP4 receptor

Bioorganic & medicinal chemistry letters, 2008-03, Vol.18 (6), p.2048-2054

2008

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Enantioselective synthesis of GNE-6688, a potent and selective inhibitor of interleukin-2 inducible T-cell kinase (ITK)

Tetrahedron letters, 2019-03, Vol.60 (11), p.785-788

2019

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Synthesis and Confirmation of the Absolute Stereochemistry of the (−)-Aflastatin A C9−C27 Degradation Polyol

Organic letters, 2005-07, Vol.7 (15), p.3335-3338

2005

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Novel pyridone EP 4 agonists featuring allylic alcohol ω-chains

Bioorganic & medicinal chemistry letters, 2020-05, Vol.30 (10), p.127104

2020

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Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses

Enantioselective total synthesis of callipeltoside A: two approaches to the macrolactone fragment

Could AlphaFold revolutionize chemical therapeutics?

One-Pot Synthesis of Benzofurans via Palladium-Catalyzed Enolate Arylation with o-Bromophenols

Enantioselective Total Synthesis of Callipeltoside A

Total Synthesis of Aflastatin A

Fragment Molecular Orbital Method Applied to Lead Optimization of Novel Interleukin‑2 Inducible T‑Cell Kinase (ITK) Inhibitors

Novel pyridone EP4 agonists featuring allylic alcohol ω-chains

Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase

Mutual antagonistic relationship between prostaglandin E₂ and IFN-γ: Implications for rheumatoid arthritis

Complex Aldol Reactions for the Construction of Dense Polyol Stereoarrays: Synthesis of the C33−C36 Region of Aflastatin A

Back Pocket Flexibility Provides Group II p21-Activated Kinase (PAK) Selectivity for Type I 1/2 Kinase Inhibitors

Tetrahydroindazoles as Interleukin‑2 Inducible T‑Cell Kinase Inhibitors. Part II. Second-Generation Analogues with Enhanced Potency, Selectivity, and Pharmacodynamic Modulation in Vivo

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response

Property- and Structure-Guided Discovery of a Tetrahydroindazole Series of Interleukin‑2 Inducible T‑Cell Kinase Inhibitors

Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors

Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK)

Structure-based design and synthesis of potent benzothiazole inhibitors of interleukin-2 inducible T cell kinase (ITK)

Mutual antagonistic relationship between prostaglandin E 2 and IFN‐γ: Implications for rheumatoid arthritis

Asymmetric Synthesis of the Chlorocyclopropane-Containing Callipeltoside A Side Chain

Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP₄ receptor

Structure-activity relationships and pharmacokinetic parameters of quinoline acylsulfonamides as potent and selective antagonists of the EP4 receptor

Enantioselective synthesis of GNE-6688, a potent and selective inhibitor of interleukin-2 inducible T-cell kinase (ITK)

Synthesis and Confirmation of the Absolute Stereochemistry of the (−)-Aflastatin A C9−C27 Degradation Polyol

Novel pyridone EP 4 agonists featuring allylic alcohol ω-chains

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