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Integration of fingerprint-based similarity searching and kernel-based partial least squares analysis to predict inhibitory activity against CSK, HER2, JAK1, JAK2, and JAK3

Molecular diversity, 2024-04, Vol.28 (2), p.497-507

2024

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The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models

Nature communications, 2014-10, Vol.5 (1), p.5086-5086, Article 5086

2014

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Synthesis, biological evaluation and 3D-QSAR studies of 3-keto salicylic acid chalcones and related amides as novel HIV-1 integrase inhibitors

Bioorganic & medicinal chemistry, 2011-03, Vol.19 (6), p.2030-2045

2011

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Dipyridamole analogs as pharmacological inhibitors of equilibrative nucleoside transporters. Identification of novel potent and selective inhibitors of the adenosine transporter function of human equilibrative nucleoside transporter 4 (hENT4)

Biochemical pharmacology, 2013-12, Vol.86 (11), p.1531-1540

2013

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A novel RNA variant of human concentrative nucleoside transporter 1 (hCNT1) that is a potential cancer biomarker

Experimental hematology & oncology, 2019-08, Vol.8 (1), p.18-18, Article 18

2019

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JKA97, a novel benzylidene analog of harmine, exerts anti-cancer effects by inducing G1 arrest, apoptosis, and p53-independent up-regulation of p21

PloS one, 2012-04, Vol.7 (4), p.e34303

2012

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Inhibiting β-Catenin by β-Carboline-Type MDM2 Inhibitor for Pancreatic Cancer Therapy

Frontiers in pharmacology, 2018-01, Vol.9, p.5-5

2018

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Targeting MDM2 for Neuroblastoma Therapy: In Vitro and In Vivo Anticancer Activity and Mechanism of Action

Cancers, 2020-12, Vol.12 (12), p.3651

2020

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Synthesis and biological evaluation of novel 5( H)-phenanthridin-6-ones, 5( H)-phenanthridin-6-one diketo acid, and polycyclic aromatic diketo acid analogs as new HIV-1 integrase inhibitors

Bioorganic & medicinal chemistry, 2007-02, Vol.15 (3), p.1212-1228

2007

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Design, Synthesis, and Evaluation of 2-Diethanolamino-4,8-diheptamethyleneimino-2-(N-aminoethyl-N-ethanolamino)-6-(N,N-diethanolamino)pyrimido[5,4-d]pyrimidine-fluorescein Conjugate (8MDP-fluor), As a Novel Equilibrative Nucleoside Transporter Probe

Bioconjugate chemistry, 2011-06, Vol.22 (6), p.1221-1227

2011

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Targeted Brain Tumor Therapy by Inhibiting the MDM2 Oncogene: In Vitro and In Vivo Antitumor Activity and Mechanism of Action

Cells (Basel, Switzerland), 2020-07, Vol.9 (7), p.1592

2020

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Synthesis and biological evaluation of phloridzin analogs as human concentrative nucleoside transporter 3 (hCNT3) inhibitors

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.917-921

2009

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SS-4 is a highly selective small molecule inhibitor of STAT3 tyrosine phosphorylation that potently inhibits GBM tumorigenesis in vitro and in vivo

Cancer letters, 2022-05, Vol.533, p.215614-215614, Article 215614

2022

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Targeting EGFR and HER-2 receptor tyrosine kinases for cancer drug discovery and development

Medicinal research reviews, 2006-09, Vol.26 (5), p.569-594

2006

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Anti-cancer Effects of JKA97 Are Associated with Its Induction of Cell Apoptosis via a Bax-dependent and p53-independent Pathway

The Journal of biological chemistry, 2008-03, Vol.283 (13), p.8624-8633

2008

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Identification of a New Class of MDM2 Inhibitor That Inhibits Growth of Orthotopic Pancreatic Tumors in Mice

Gastroenterology (New York, N.Y. 1943), 2014-10, Vol.147 (4), p.893-902.e2

2014

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Identification of the ENT1 Antagonists Dipyridamole and Dilazep as Amplifiers of Oncolytic Herpes Simplex Virus-1 Replication

Cancer research (Chicago, Ill.), 2010-05, Vol.70 (10), p.3890-3895

2010

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QSAR studies of new pyrido[3,4-b]indole derivatives as inhibitors of colon and pancreatic cancer cell proliferation

Medicinal chemistry research, 2018-12, Vol.27 (11-12), p.2466-2481

2018

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Synthesis, docking, and biological studies of phenanthrene β-diketo acids as novel HIV-1 integrase inhibitors

Bioorganic & medicinal chemistry letters, 2013-11, Vol.23 (22), p.6146-6151

2013

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Homology Model-Guided 3D-QSAR Studies of HIV-1 Integrase Inhibitors

Journal of chemical information and modeling, 2012-02, Vol.52 (2), p.515-544

2012

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CoMFA and CoMSIA 3D QSAR and Docking Studies on Conformationally-Restrained Cinnamoyl HIV-1 Integrase Inhibitors: Exploration of a Binding Mode at the Active Site

Journal of medicinal chemistry, 2002-02, Vol.45 (4), p.841-852

2002

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Inhibition of gastric tumor growth by a novel Hsp90 inhibitor

Biochemical pharmacology, 2013-05, Vol.85 (9), p.1246-1256

2013

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Synthesis, Flow Cytometric Evaluation, and Identification of Highly Potent Dipyridamole Analogues as Equilibrative Nucleoside Transporter 1 Inhibitors

Journal of medicinal chemistry, 2007-08, Vol.50 (16), p.3906-3920

2007

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Interaction of benzopyranone derivatives and related compounds with human concentrative nucleoside transporters 1, 2 and 3 heterologously expressed in porcine PK15 nucleoside transporter deficient cells. Structure–activity relationships and determinants of transporter affinity and selectivity

Biochemical pharmacology, 2010-02, Vol.79 (3), p.307-320

2010

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Novel anticancer drug discovery

Current opinion in chemical biology, 1999-08, Vol.3 (4), p.500-509

Buolamwini, J K

1999

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Integration of fingerprint-based similarity searching and kernel-based partial least squares analysis to predict inhibitory activity against CSK, HER2, JAK1, JAK2, and JAK3

The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models

Synthesis, biological evaluation and 3D-QSAR studies of 3-keto salicylic acid chalcones and related amides as novel HIV-1 integrase inhibitors

Dipyridamole analogs as pharmacological inhibitors of equilibrative nucleoside transporters. Identification of novel potent and selective inhibitors of the adenosine transporter function of human equilibrative nucleoside transporter 4 (hENT4)

A novel RNA variant of human concentrative nucleoside transporter 1 (hCNT1) that is a potential cancer biomarker

JKA97, a novel benzylidene analog of harmine, exerts anti-cancer effects by inducing G1 arrest, apoptosis, and p53-independent up-regulation of p21

Inhibiting β-Catenin by β-Carboline-Type MDM2 Inhibitor for Pancreatic Cancer Therapy

Targeting MDM2 for Neuroblastoma Therapy: In Vitro and In Vivo Anticancer Activity and Mechanism of Action

Synthesis and biological evaluation of novel 5( H)-phenanthridin-6-ones, 5( H)-phenanthridin-6-one diketo acid, and polycyclic aromatic diketo acid analogs as new HIV-1 integrase inhibitors

Design, Synthesis, and Evaluation of 2-Diethanolamino-4,8-diheptamethyleneimino-2-(N-aminoethyl-N-ethanolamino)-6-(N,N-diethanolamino)pyrimido[5,4-d]pyrimidine-fluorescein Conjugate (8MDP-fluor), As a Novel Equilibrative Nucleoside Transporter Probe

Targeted Brain Tumor Therapy by Inhibiting the MDM2 Oncogene: In Vitro and In Vivo Antitumor Activity and Mechanism of Action

Synthesis and biological evaluation of phloridzin analogs as human concentrative nucleoside transporter 3 (hCNT3) inhibitors

SS-4 is a highly selective small molecule inhibitor of STAT3 tyrosine phosphorylation that potently inhibits GBM tumorigenesis in vitro and in vivo

Targeting EGFR and HER-2 receptor tyrosine kinases for cancer drug discovery and development

Anti-cancer Effects of JKA97 Are Associated with Its Induction of Cell Apoptosis via a Bax-dependent and p53-independent Pathway

Identification of a New Class of MDM2 Inhibitor That Inhibits Growth of Orthotopic Pancreatic Tumors in Mice

Identification of the ENT1 Antagonists Dipyridamole and Dilazep as Amplifiers of Oncolytic Herpes Simplex Virus-1 Replication

QSAR studies of new pyrido[3,4-b]indole derivatives as inhibitors of colon and pancreatic cancer cell proliferation

Synthesis, docking, and biological studies of phenanthrene β-diketo acids as novel HIV-1 integrase inhibitors

Homology Model-Guided 3D-QSAR Studies of HIV-1 Integrase Inhibitors

CoMFA and CoMSIA 3D QSAR and Docking Studies on Conformationally-Restrained Cinnamoyl HIV-1 Integrase Inhibitors: Exploration of a Binding Mode at the Active Site

Inhibition of gastric tumor growth by a novel Hsp90 inhibitor

Synthesis, Flow Cytometric Evaluation, and Identification of Highly Potent Dipyridamole Analogues as Equilibrative Nucleoside Transporter 1 Inhibitors

Interaction of benzopyranone derivatives and related compounds with human concentrative nucleoside transporters 1, 2 and 3 heterologously expressed in porcine PK15 nucleoside transporter deficient cells. Structure–activity relationships and determinants of transporter affinity and selectivity

Novel anticancer drug discovery

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