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Scalable Synthesis of 1-Bicyclo[1.1.1]pentylamine via a Hydrohydrazination Reaction

Organic letters, 2011-09, Vol.13 (17), p.4746-4748

2011

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Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer

Journal of medicinal chemistry, 2021-09, Vol.64 (17), p.13004-13024

2021

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Acid-Induced Liberation of Polysubstituted Cyclopentadiene Ligands from Cyclopentadienyl Cobalt: A [2 + 2 + 1] Cycloaddition Route toward 1,2,4-Trisubstituted Cyclopentadienes

Journal of organic chemistry, 2019-11, Vol.84 (21), p.13992-14004

2019

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Evaluation of KP‐1199: a novel acetaminophen analog for hemostatic function and antinociceptive effects

Transfusion (Philadelphia, Pa.), 2021-07, Vol.61 (S1), p.S234-S242

2021

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Structural Characterization of (C5H5)Co(PPh3)(η2‑alkyne) and (C5H5)Co(η2‑alkyne) Complexes of Highly Polarized Alkynes

Organometallics, 2013-10, Vol.32 (19), p.5473-5480

2013

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An efficient synthesis of highly functionalized chiral lactams

Tetrahedron letters, 2011-09, Vol.52 (37), p.4760-4763

2011

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Reactions of a Metallacyclobutene Complex with Alkenes

Journal of the American Chemical Society, 2008-08, Vol.130 (31), p.10093-10095

2008

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Abstract 1965: Discovery of ZN-c3, a potent Wee-1 inhibitor with a differentiated pharmacologic and kinase selectivity profile

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1965-1965

2021

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Sulfoxide Carbon−Sulfur Bond Activation

Journal of the American Chemical Society, 2005-03, Vol.127 (12), p.4180-4181

2005

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Abstract 2423: Discovery of ZN-e4, an irreversible EGFR-TKI with potent anti-tumor activity in EGFR mutant non-small-cell lung cancer

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.2423-2423

2021

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Thermolysis of [(η 5-C 5H 5)Co(PPh 3)(η 2-DMAD)], revisited: a solid state analysis reveals the true structure of the triphenylphosphine–alkyne coupling product

Journal of organometallic chemistry, 2003-04, Vol.671 (1), p.1-7

2003

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3-Amino-5-bromo-2-iodopyridine

Acta crystallographica. Section E, Structure reports online, 2009-01, Vol.65 (1), p.o28-o28

2009

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Conversion of (η5-C5H5)Co(PPh3)2 and Nitro Compounds to Mononuclear η1(N)-Nitrosoalkyl and Dinuclear μ-η1(N):η2(N,O)-Nitrosoaryl Complexes

Organometallics, 2003-12, Vol.22 (25), p.5268-5273

2003

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2-Chloro-4-(1H-pyrazol-1-yl)-5-(trifluoro-meth-yl)pyrimidine

Acta crystallographica. Section E, Structure reports online, 2010-05, Vol.66 (Pt 6), p.o1448-o1448

2010

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Abstract 2605: BH3 mimetics synergize with the Wee1 inhibitor ZN-c3 by activating caspases which induce DNA damage and degrade key proteins

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.2605-2605

2022

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Abstract 2591: Combination of the BCL-2 inhibitor ZN-d5 with the WEE1 inhibitor ZN-c3 shows additive or synergistic anti-tumor activity in acute myeloid leukemia (AML) models

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.2591-2591

2022

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Ring-strain effects on the oxidation potential of enediynes and enediyne complexes

Organic & biomolecular chemistry, 2003-03, Vol.1 (5), p.763-766

2003

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Stereospecific Oxidative Demetallation of Highly Functionalized CpCo(1,3-Diene) Complexes: An Experimental and Computational Study

Synlett, 2015-10, Vol.26 (16), p.2243-2246

2015

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Synthesis of the cobalt–alkyne complex (η5-C5H5)(PPh3)Co{η2-(Me3Si)CC(CO2Et)} and structural characterization of trimethylsilyl substituted cobaltacyclopentadiene complexes derived therefrom

Journal of organometallic chemistry, 2014-01, Vol.749, p.100-105

2014

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4-Chloro-7-hydr-oxy-6-methyl-1,7-naphthyridin-8(7H)-one

Acta crystallographica. Section E, Structure reports online, 2009-11, Vol.65 (Pt 12), p.o3259-o3259

2009

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Conversion of (η 5 -C 5 H 5 )Co(PPh 3 ) 2 and Nitro Compounds to Mononuclear η 1 ( N )-Nitrosoalkyl and Dinuclear μ-η 1 ( N ):η 2 ( N , O )-Nitrosoaryl Complexes

Organometallics, 2003-12, Vol.22 (25), p.5268-5273

2003

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4-Chloro-7-hydroxy-6-methyl-1,7-naphthyridin-8(7 H )-one

Acta crystallographica. Section E, Structure reports online, 2009-12, Vol.65 (12), p.o3259-o3259

2009

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3-Amino-5-bromo-2-iodo-pyridine

Acta crystallographica. Section E, Structure reports online, 2008-12, Vol.65 (Pt 1), p.o28-o28

2008

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Late-metal metallacyclobutenes: Synthesis, isolation, and reactivity studies of cobaltacyclobutenes

Bunker, Kevin D

2003

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Scalable Synthesis of 1-Bicyclo[1.1.1]pentylamine via a Hydrohydrazination Reaction

Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer

Acid-Induced Liberation of Polysubstituted Cyclopentadiene Ligands from Cyclopentadienyl Cobalt: A [2 + 2 + 1] Cycloaddition Route toward 1,2,4-Trisubstituted Cyclopentadienes

Evaluation of KP‐1199: a novel acetaminophen analog for hemostatic function and antinociceptive effects

Structural Characterization of (C5H5)Co(PPh3)(η2‑alkyne) and (C5H5)Co(η2‑alkyne) Complexes of Highly Polarized Alkynes

An efficient synthesis of highly functionalized chiral lactams

Reactions of a Metallacyclobutene Complex with Alkenes

Abstract 1965: Discovery of ZN-c3, a potent Wee-1 inhibitor with a differentiated pharmacologic and kinase selectivity profile

Sulfoxide Carbon−Sulfur Bond Activation

Abstract 2423: Discovery of ZN-e4, an irreversible EGFR-TKI with potent anti-tumor activity in EGFR mutant non-small-cell lung cancer

Thermolysis of [(η 5-C 5H 5)Co(PPh 3)(η 2-DMAD)], revisited: a solid state analysis reveals the true structure of the triphenylphosphine–alkyne coupling product

Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib

3-Amino-5-bromo-2-iodopyridine

Conversion of (η5-C5H5)Co(PPh3)2 and Nitro Compounds to Mononuclear η1(N)-Nitrosoalkyl and Dinuclear μ-η1(N):η2(N,O)-Nitrosoaryl Complexes

2-Chloro-4-(1H-pyrazol-1-yl)-5-(trifluoro-meth-yl)pyrimidine

Abstract 2605: BH3 mimetics synergize with the Wee1 inhibitor ZN-c3 by activating caspases which induce DNA damage and degrade key proteins

Abstract 2591: Combination of the BCL-2 inhibitor ZN-d5 with the WEE1 inhibitor ZN-c3 shows additive or synergistic anti-tumor activity in acute myeloid leukemia (AML) models

Ring-strain effects on the oxidation potential of enediynes and enediyne complexes

Stereospecific Oxidative Demetallation of Highly Functionalized CpCo(1,3-Diene) Complexes: An Experimental and Computational Study

Synthesis of the cobalt–alkyne complex (η5-C5H5)(PPh3)Co{η2-(Me3Si)CC(CO2Et)} and structural characterization of trimethylsilyl substituted cobaltacyclopentadiene complexes derived therefrom

4-Chloro-7-hydr-oxy-6-methyl-1,7-naphthyridin-8(7H)-one

Conversion of (η 5 -C 5 H 5 )Co(PPh 3 ) 2 and Nitro Compounds to Mononuclear η 1 ( N )-Nitrosoalkyl and Dinuclear μ-η 1 ( N ):η 2 ( N , O )-Nitrosoaryl Complexes

4-Chloro-7-hydroxy-6-methyl-1,7-naphthyridin-8(7 H )-one

3-Amino-5-bromo-2-iodo-pyridine

Late-metal metallacyclobutenes: Synthesis, isolation, and reactivity studies of cobaltacyclobutenes

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