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Preclinical evaluation of WVE-004, aninvestigational stereopure oligonucleotide forthe treatment of C9orf72 -associated ALS or FTD

Molecular therapy. Nucleic acids, 2022-06, Vol.28, p.558-570

2022

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The Underlying Mechanism for the Diversity of Disulfide Folding Pathways

The Journal of biological chemistry, 2000-03, Vol.275 (12), p.8287-8289

2000

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Class C β-Lactamases Operate at the Diffusion Limit for Turnover of Their Preferred Cephalosporin Substrates

Antimicrobial Agents and Chemotherapy, 1999-07, Vol.43 (7), p.1743-1746

1999

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Preclinical evaluation of WVE-004, an investigational stereopure oligonucleotide for the treatment of C9orf72-associated ALS or FTD

Molecular therapy. Nucleic acids, 2022-06, Vol.28, p.558-570

2022

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The importance of a critical protonation state and the fate of the catalytic steps in class A beta-lactamases and penicillin-binding proteins

The Journal of biological chemistry, 2004-08, Vol.279 (33), p.34665-34673

2004

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Nuances of Mechanisms and Their Implications for Evolution of the Versatile β-Lactamase Activity: From Biosynthetic Enzymes to Drug Resistance Factors

Journal of the American Chemical Society, 1997-08, Vol.119 (33), p.7619-7625

1997

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Inhibition of the NMC-A β-Lactamase by a Penicillanic Acid Derivative and the Structural Bases for the Increase in Substrate Profile of This Antibiotic Resistance Enzyme

Journal of the American Chemical Society, 1998-09, Vol.120 (36), p.9382-9383

1998

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N-Sulfonyloxy-β-lactam Inhibitors for β-Lactamases

Tetrahedron, 2000-07, Vol.56 (31), p.5719-5728

2000

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A stabilized molten globule protein

FEBS letters, 2000-12, Vol.487 (2), p.298-300

2000

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X-ray Structure of the Asn276Asp Variant of the Escherichia coli TEM-1 β-Lactamase: Direct Observation of Electrostatic Modulation in Resistance to Inactivation by Clavulanic Acid

Biochemistry (Easton), 1999-07, Vol.38 (30), p.9570-9576

1999

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The Importance of a Critical Protonation State and the Fate of the Catalytic Steps in Class A Î²-Lactamases and Penicillin-binding Proteins

The Journal of biological chemistry, 2004-08, Vol.279 (33), p.34665

2004

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Elucidation of Mechanism of Inhibition and X-ray Structure of the TEM-1 β-Lactamase from Escherichia coli Inhibited by a N-Sulfonyloxy-β-lactam

Journal of the American Chemical Society, 1999-06, Vol.121 (23), p.5353-5359

1999

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Penem BRL 42715: An Effective Inactivator for .beta.-Lactamases

Journal of the American Chemical Society, 1995-05, Vol.117 (17), p.4797-4801

1995

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Inhibition of the broad spectrum nonmetallocarbapenamase of class A (NMC-A) beta-lactamase from Enterobacter cloacae by monocyclic beta-lactams

The Journal of biological chemistry, 1999-09, Vol.274 (36), p.25260-25265

1999

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Beta-lactamases: Mechanism of action and inhibition

Bulychev, Alexey

1999

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ProQuest

Hydrogen Bonding and Attenuation of the Rate of Enzymic Catalysis

Journal of the American Chemical Society, 1998-12, Vol.120 (50), p.13003-13007

1998

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Unfolding of hirudin characterized by the composition of denatured scrambled isomers

Journal of Protein Chemistry, 1999-10, Vol.18 (7), p.771-778

1999

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Inhibition of the Broad Spectrum Nonmetallocarbapenamase of Class A (NMC-A) ␤-Lactamase from Enterobacter cloacae by Monocyclic ␤-Lactams □ S

The Journal of biological chemistry, 1999-09, Vol.274, p.25260-25265

1999

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Inhibition of the Broad Spectrum Nonmetallocarbapenamase of Class A (NMC-A) Î²-Lactamase from Enterobacter cloacae by Monocyclic Î²-Lactams

The Journal of biological chemistry, 1999-09, Vol.274 (36), p.25260

1999

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Inhibition of the Broad Spectrum Nonmetallocarbapenamase of Class A (NMC-A) β-Lactamase from Enterobacter cloacae by Monocyclic β-Lactams210

The Journal of biological chemistry, 1999-09, Vol.274 (36), p.25260-25265

1999

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Potent mechanism-based inhibition of the TEM-1 .beta.-lactamase by novel N-sulfonyloxy .beta.-lactams

Journal of the American Chemical Society, 1995-06, Vol.117 (22), p.5938-5943

1995

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Templates for design of inhibitors for serine proteases: Application of the program dock to the discovery of novel inhibitors for thrombin

Bioorganic & medicinal chemistry letters, 1998-09, Vol.8 (18), p.2463-2466

1998

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New effective chemically synthesized anti-smallpox compound NIOCH-14

Journal of general virology, 2016-05, Vol.97 (5), p.1229-1239

2016

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Intercellular permeation and cyclosis-mediated transport of a fluorescent probe in Characeae

Biophysical journal, 2023-01, Vol.122 (2), p.419-432

2023

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Effects of cell excitation on photosynthetic electron flow and intercellular transport in Chara

Protoplasma, 2023, Vol.260 (1), p.131-143

2023

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Preclinical evaluation of WVE-004, aninvestigational stereopure oligonucleotide forthe treatment of C9orf72 -associated ALS or FTD

The Underlying Mechanism for the Diversity of Disulfide Folding Pathways

Class C β-Lactamases Operate at the Diffusion Limit for Turnover of Their Preferred Cephalosporin Substrates

Preclinical evaluation of WVE-004, an investigational stereopure oligonucleotide for the treatment of C9orf72-associated ALS or FTD

The importance of a critical protonation state and the fate of the catalytic steps in class A beta-lactamases and penicillin-binding proteins

Nuances of Mechanisms and Their Implications for Evolution of the Versatile β-Lactamase Activity: From Biosynthetic Enzymes to Drug Resistance Factors

Inhibition of the NMC-A β-Lactamase by a Penicillanic Acid Derivative and the Structural Bases for the Increase in Substrate Profile of This Antibiotic Resistance Enzyme

N-Sulfonyloxy-β-lactam Inhibitors for β-Lactamases

A stabilized molten globule protein

X-ray Structure of the Asn276Asp Variant of the Escherichia coli TEM-1 β-Lactamase: Direct Observation of Electrostatic Modulation in Resistance to Inactivation by Clavulanic Acid

The Importance of a Critical Protonation State and the Fate of the Catalytic Steps in Class A Î²-Lactamases and Penicillin-binding Proteins

Elucidation of Mechanism of Inhibition and X-ray Structure of the TEM-1 β-Lactamase from Escherichia coli Inhibited by a N-Sulfonyloxy-β-lactam

Penem BRL 42715: An Effective Inactivator for .beta.-Lactamases

Inhibition of the broad spectrum nonmetallocarbapenamase of class A (NMC-A) beta-lactamase from Enterobacter cloacae by monocyclic beta-lactams

Beta-lactamases: Mechanism of action and inhibition

Hydrogen Bonding and Attenuation of the Rate of Enzymic Catalysis

Unfolding of hirudin characterized by the composition of denatured scrambled isomers

Inhibition of the Broad Spectrum Nonmetallocarbapenamase of Class A (NMC-A) ␤-Lactamase from Enterobacter cloacae by Monocyclic ␤-Lactams □ S

Inhibition of the Broad Spectrum Nonmetallocarbapenamase of Class A (NMC-A) Î²-Lactamase from Enterobacter cloacae by Monocyclic Î²-Lactams

Inhibition of the Broad Spectrum Nonmetallocarbapenamase of Class A (NMC-A) β-Lactamase from Enterobacter cloacae by Monocyclic β-Lactams210

Potent mechanism-based inhibition of the TEM-1 .beta.-lactamase by novel N-sulfonyloxy .beta.-lactams

Templates for design of inhibitors for serine proteases: Application of the program dock to the discovery of novel inhibitors for thrombin

New effective chemically synthesized anti-smallpox compound NIOCH-14

Intercellular permeation and cyclosis-mediated transport of a fluorescent probe in Characeae

Effects of cell excitation on photosynthetic electron flow and intercellular transport in Chara

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